Treatment and prophylaxis of the lower urinary tract recurrent infections in women

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Abstract

Treatment of 52 women with uncomplicated recurrent lower urinary tract infection aged 19 to 56 years (mean age – 34.4 ± 9.6 years) was performed. All patients were prescribed an antibacterial nitrofuran series drug UrofuraginТМ (Furazidin) at a dose of 100 mg 3 times a day for 7 days. Treatment was started in the period of exacerbation of the disease. After the end of the treatment the postcoital antimicrobial prophylaxis (100 mg Urofuragin single dose) was prescribed. The dynamics of clinical and laboratory parameters were evaluated immediately after treatment, 2 and 12 weeks after its completion. Before treatment the bacteriological study of urine showed the presence of more than 103 CFU/ml in 38 (73.1%) out of 52 patients and in 29 patients Escherichia coli was detected. Positive dynamics of clinical and laboratory parameters were noted after the end of treatment. By 2 weeks after the end of treatment, 47 patients (90.4%) had no leukocyturia, 41 (78.8%) had no bacteriuria and at 12 weeks of follow-up same results were achieved in 45 (86.5%) and 40 (76.9%) out of 52 treated patients respectively. During the follow-up period of 12 weeks after the end of treatment, recurrence of lower urinary tract infection was observed only in 8 (15.4%) patients, which occurred on average 48.4 ± 14.1 days after the end of treatment. Tolerance to Urofuragin was satisfactory. Adverse events associated with the drug were noted in 12 (23.1%) patients but they did not lead to the drug withdrawal. The results of the study showed that Urofuragin is an effective antibacterial drug for treatment and prevention of recurrence of uncomplicated infections of the lower urinary tract.

About the authors

Igor V. Kuzmin

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: kuzminigor@mail.ru

Doctor of Medical Science, Professor. Department of Urology

Russian Federation, Saint Petersburg

Salman Kh. Al-Shukri

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation

Email: alshukri@mail.ru

Doctor of Medical Science, Professor, Head of the Department of Urology

Russian Federation, Saint Petersburg

Margarita N. Slesarevskaya

Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation

Email: mns-1971@yandex.ru

Candidate of Medical Science, Senior Research Fellow

Russian Federation, Saint Petersburg

References

  1. Урология. Российские клинические рекомендации / Под ред. Ю.Г. Аляева, П.В. Глыбочко, Д.Ю. Пушкаря. – М.: ГЭОТАР-Медиа, 2016. – 496 с. [Urologija. Rossijskie klinicheskie rekomendacii. Ed. by Yu.G. Aljaev, P.V. Glybochko, D.Yu. Pushkar. Moscow: GEOTAR-Media; 2016. 496 p. (in Russ.)].
  2. Hooton TM. Clinical practice. Uncomplicated urinary tract infections. N Engl J Med. 2012;366(11):1028-1037. https://doi.org/10.1056/NEJMcp1104429.
  3. Перепанова Т.С. Неосложненная инфекция мочевых путей // Рациональная фармакотерапия в урологии: руководство для практикующих врачей / Под ред. Н.А. Лопаткина, Т.С. Перепановой. – 2-е изд. – М.: Литтерра, 2012. – С. 303–318. [Perepanova T.S. Neoslozhnennaja infekcija mochevyh putej. In: Racional’naja farmakoterapija v urologii: rukovodstvo dlja praktikujushhih vrachej. Ed by N.A. Lopatkin, T.S. Perepanova. 2nd ed. Moscow: Litterra; 2012. P. 303-318. (In Russ.)]
  4. Little P, Moore MV, Turner S, et al. Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial. BMJ. 2010;340: c199. https://doi.org/10.1136/bmj.c199.
  5. Перепанова Т.С., Козлов Р.С., Дехнич А.В., и др. Эмпирический выбор антимикробных препаратов при неосложненной инфекции нижних мочевых путей: исследование резистентности возбудителей ДАРМИС // Экспериментальная и клиническая урология. – 2012. – № 2. – С. 78–83. [Perepanova TS, Kozlov RS, Dehnich AV, et al. The empirical choice of antibacterial treatment for uncomplicated urinary tract infection. DARMIS: clinical study of pathogens resistance. Experimental and clinical urology. 2012;(2):78-83. (In Russ.)]
  6. Борисов В.В. Диагностика и терапия инфекций мочевыводящих путей. О чем следует помнить всегда (клиническая лекция). Часть 1 // Урологические ведомости. – 2017. – Т. 7. – № 3. – С. 52–59. [Borisov VV. Diagnosis and therapy of urinary infections. What should always remember (clinical lecture). Part 1. Urologicheskie vedomosti. 2017;7(3):52-59. (In Russ.)]. https://doi.org/10.17816/uroved7352-59.
  7. Перепанова Т.С., Хазан П.Л., Волкова Е.М., и др. Проблемы лечения рецидивирующей инфекции нижних мочевых путей [Медицинский портал для врачей] // Эффективная фармакотерапия. Урология и нефрология. – 2011. – № 3. – С. 38–43. [Perepanova TS, Hazan PL, Volkova EM, et al. Problemy lechenija recidivirujushhej infekcii nizhnih mochevyh putej [Meditsinskij portal dlya vrachej]. Effektivnaja farmakoterapija. Urologiya i Nefrologiya. 2011;(3):38-43. (In Russ.)]. Доступно по: http://umedp.ru/upload/iblock/011/011c079c4a44c06082b107bb6074636a.pdf. Ссылка активна на 15.05.2019.
  8. Wagenlehner FM, Weidner W, Naber KG. An update on uncomplicated urinary tract infections in women. Curr Opin Urol. 2009;19(4):368-374. https://doi.org/10.1097/MOU.0b013e32832ae18c.
  9. Аль-Шукри С.Х., Слесаревская М.Н., Кузьмин И.В. Применение фосфомицина при лечении неосложненной инфекции нижних мочевыводящих путей // Урология. – 2018. – № 5. – С. 153–159. [Al-Shukri SKh, Slesarevskaya MN, Kuz’min IV. Fosfomycin for treatment of uncomplicated lower urinary tract infection. Urologiia. 2018;(5):153-159. (In Russ.)]. https://doi.org/10.18565/urology.2018.5.153-158.
  10. Голуб А.В. Нитрофураны в терапии неосложненных инфекций мочевых путей [Медицинский портал для врачей] // Эффективная фармакотерапия. Урология и нефрология. – 2010. – № 3. – С. 30–34. [Golub AV. Nitrofurany v terapii neoslozhnennyh infekcij mochevyh putej [Meditsinskij portal dlya vrachej]. Effektivnaja farmakoterapija. Urologiya i Nephrologiya. 2010;(3):30-34. (In Russ.)]. Доступно по: http://umedp.ru/upload/iblock/858/furamag.pdf. Ссылка активна на 15.05.2019.
  11. Перепанова Т.С. Нитрофураны в урологической практике: все ли они одинаковы и почему мы возвращаемся к ним сегодня? // Экспериментальная и клиническая урология. – 2018. – № 3. – С. 91–101. [Perepanova TS. Nitrofurans in the urological practice: are they all the same and why are we getting back to them today? Experimental and clinical urology. 2018;(3):91-101. (In Russ.)]
  12. Вощула В.И., Вилюха А.И. Неосложненная инфекция мочевыводящих путей: длительный прием нитрофуранов для профилактики рецидивирования // Экспериментальная и клиническая урология. – 2014. – № 1. – C. 88–91. [Voschula VI, Vilyuha AI. Non-complicated urinary tract infections: long-term intake of nitrofurans for recurrence prevention. Experimental and clinical urology. 2014;(1):88-91. (In Russ.)]
  13. Пронкин Е.А. Неосложненные инфекции мочевыводящих путей у женщин — комплексная терапия // Урология. – 2018. – № 3. – С. 146–148. [Pronkin EA. Uncomplicated female urinary tract infections – comprehensive therapy. Urologiia. 2018;(3):146-148. (In Russ.)]. https://doi.org/10.18565/urology.2018.3.146-148.
  14. Слесаревская М.Н., Кузьмин И.В., Аль-Шукри С.Х. Фитолизин nefroCAPS в комплексном лечении женщин с хроническим рецидивирующим циститом // Урология. – 2018. – № 1. – С. 30–34. [Slesarevskaya MN, Kuzmin IV, Al-Shukri SKh. NefroCAPS phytolysin in complex management of women with chronic recurrent cystitis. Urologiia. 2018;(1):30-34. (In Russ.)]. https://doi.org/10.18565/urology.2018.1.30-34.
  15. Амдий Р.Э., Аль-Шукри С.Х., Кузьмин И.В., и др. Опыт применения канефрона при лечении острого неосложненного цистита у женщин // Урологические ведомости. – 2016. – Т. 6. – № 2. – С. 16–22. [Amdiy RE, Al-Shukri SKh, Kuzmin IV, et al. Use of Kanefron in treatment of acute uncomplicated cystitis in women. Urologicheskie vedomosti. 2016;6(2):16-22. (In Russ.)]. https://doi.org/10.17816/uroved6216-22.
  16. Аль-Шукри С.Х., Кузьмин И.В., Слесаревская М.Н., Игнашов Ю.А. Применение русскоязычной версии «Шкалы симптомов тазовой боли, ургентности и частоты мочеиспускания» (PUF Scale) у больных с синдромом болезненного мочевого пузыря // Урологические ведомости. – 2017. – Т. 7. – № 2. – С. 5–9. [Al-Shukri SKh, Kuzmin IV, Slesarevskaya MN, Ignashov YuA. Use of the Russian version of pelvic pain and urgency/frequency patient symptom scale (PUF scale) in patients with the bladder pain syndrome. Urologicheskie vedomosti. 2017;7(2):5-9. (In Russ.)]. https://doi.org/10.17816/uroved725-9.

Copyright (c) 2019 Kuzmin I.V., Al-Shukri S.K., Slesarevskaya M.N.

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