Analysis of diurnal variability of sperm donors’ semen parameters

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Abstract

Introduction. Diurnal variability of sperm parameters is controversial and should be considered during medical evaluation and solicitation of sperm donors.

Aim: to evaluate diurnal variability of sperm parameters of anonymous sperm donors in reproductive medicine center.

Materials and methods. Records of 1253 semen samples analysis of 39 sperm donors (mean age 27.1 ± 3.9 years) were retrospectively studied in reproductive medicine center in Saint Petersburg. Semen analysis was performed according to WHO 2010 recommendations. Diurnal variations of semen volume, sperm concentration, total sperm number, progressive motility and number of progressively motile sperm were analyzed.

Results. Mean ejaculate volume, sperm total number and number of progressively motile sperm were higher after 3 p.m. (t = 5.63, p < 0.0001; t = 3.66, p = 0.0003 and t = 1.76, p = 0.078, respectively), while sperm concentration and percent of progressively motile sperm was lower (t = 2.03, p = 0.043 and t = 4.63, p = 0.0003, respectively).The lowest and the highest mean sperm numbers were registered in time slots between 12 a.m.–1 p.m. and 4 p.m.–5 p.m., respectively.

Conclusions. The study suggests the diurnal variability of sperm donors’ semen parameters. We might recommend a potential sperm donor preservation to be performed after 3 p.m., preferentially within 4 p.m.–5 p.m. interval.

About the authors

Igor A. Korneyev

Pavlov First Saint Petersburg State Medical University; International Centre for Reproductive Medicine

Author for correspondence.
Email: iakorneyev@yandex.ru

Doctor of Medical Science, Professor. Department of Urology; Medical Director

Russian Federation, Saint Petersburg

Ruslan D. Zasseev

International Centre for Reproductive Medicine

Email: r.zasseev@gmail.com

Urologist

Russian Federation, Saint Petersburg

Ol’ga B. Pashina

International Centre for Reproductive Medicine

Email: r.zasseev@gmail.com

Biologist

Russian Federation, Saint Petersburg

Ali E. Mamedov

Pavlov First Saint Petersburg State Medical University

Email: r.zasseev@gmail.com

Student

Russian Federation, Saint Petersburg

Pavel S. Kondrashkin

Pavlov First Saint Petersburg State Medical University

Email: r.zasseev@gmail.com

Student

Russian Federation, Saint Petersburg

Oleg A. Krylov

Pavlov First Saint Petersburg State Medical University

Email: r.zasseev@gmail.com

Student

Russian Federation, Saint Petersburg

References

  1. Alvarez C, Castilla JA, Martínez L, et al. Biological variation of seminal parameters in healthy subjects. Hum Reprod. 2003;18(10):2082-2088.
  2. Sergerie M, Mieusset R, Daudin M, et al. Ten-year variation in semen parameters and sperm deoxyribonucleic acid integrity in a healthy fertile man. Fertil Steril. 2006;86(5):1513.e11-8. https://doi.org/10.1016/j.fertnstert.2006.03.067.
  3. Sergerie M, Mieusset R, Croute F, et al. High risk of temporary alteration of semen parameters after recent acute febrile illness. Fertil Steril. 2007;88(4):970.e1-7. https://doi.org/10.1016/j.fertnstert.2006.12.045.
  4. Хаят С.Ш., Андреева М.В., Шилейко Л.В., и др. Анализ параметров эякулята у мужчин с нормальной концентрацией сперматозоидов и полизооспермией // Андрология и генитальная хирургия. – 2014. – № 1. – С. 34–40. [Hayat SSh, Andreeva MV, Shileyko LV, et al. Semen parameters evaluation with normal sperm concentration and polyzoospermia. Andrology and genital surgery. 2014;(1):34-40. (In Russ.)]
  5. WHO, WHO Laboratory Manual for the Examination and Processing of Human Semen. 5th ed. 2010.
  6. Jungwirth A, Diemer T, Kopa Z, et al. Male Infertility. EAU guidelines. EAU, 2018. Доступно по ссылке: http://uroweb.org/guideline/male-infertility. Ссылка активна на 22.01.2019.
  7. Чалый М.Е., Ахвледиани Н.Д., Харчилава Р.Р. Мужское бесплодие. Российские клинические рекомендации // Урология. – 2016. – № 1. – С. 2–16. [Chalyi ME, Akhvlediani ND, Kharchilava RR. Muzhskoe besplodie. Rossiiskie klinicheskie rekomendatcii. Urologiia. 2016; (1):2–16. (In Russ.)]
  8. Reinberg A, Smolensky MH, Hallek M, et al. Annual variation in semen characteristicsand plasma hormone levels in men undergoingvasectomy. Fertil Steril. 1988;49:309-315. https://doi.org/10.1016/s0015-0282(16)59721-0.
  9. Ozelci R, Yılmaz S, Dilbaz B. Seasonal variation of human sperm cells among 4,422 semen samples: A retrospective study in Turkey. Syst Biol Reprod Med. 2016;62(6):379-386. https://doi.org/10.1080/19396368.2016.1225322.
  10. Zhang XZ, Liu JH, Sheng HQ, et al. Seasonal variation in semen quality in China. Andrology. 2013;1(4):639-643. https://doi.org/10.1111/j.2047-2927.2013.00092.x.
  11. Gyllenborg J, Skakkebaek NE, Nielsen NC, et al. Secular and seasonal changes in semen quality among young Danish men: a statistical analysis of semen samples from 1927 donor candidates during 1977-1995. Int J Androl.1999; 22:28-36. https://doi.org/10.1046/j.1365-2605.1999.00137.
  12. Tomlinson M, Lewis S, Morroll D. Sperm quality and its relationship to natural and assisted conception: British Fertility Society guidelines for practice. Hum Fertil (Camb). 2013;16(3):175-93. https://doi.org/10.3109/14647273.2013.807522.
  13. Chen Z, Godfrey-Bailey L, Schiff I, et al. Impact of seasonal variation, age and smoking on humansemen parameters: The Massachusetts General Hospitalexperience. J Exp Clin Assist Reprod. 2004;1:2. https://doi.org/10.1186/1743-1050-1-2.
  14. Levitas E, Lunenfeld E, Weisz N, et al. Seasonal variations of human sperm cells among 6455 semen samples: a plausible explanation of a seasonal birth pattern. Am J Obstet Gynecol. 2013;208:406. https://doi.org/10.1016/j.ajog.2013.02.010.
  15. De Giorgi A, Volpi R, Tiseo R, et al. Seasonal variation of human semenparameters: A retrospective study in Italy. Chronobiol Int. 2015;32(5):711-6. https://doi.org/10.3109/07420528.2015.1024315.
  16. Корнеев И.А., Зассеев Р.Д., Пашина О.Б., и др. Анализ сезонной вариабельности показателей эякулята доноров спермы // Урологические ведомости. – 2018. – Т. 8. – № 3. – С. 28–35. https://doi.org/10.17816/uroved8328-35. [Korneyev IA, Zasseev RD, Pashina OB, et al. Analysis of seasonal variability of sperm donors’ semen parameters. Urologicheskie vedomosti. 2018;8(3):28-35. (In Russ.)]
  17. Xie M, Utzinger KS, Blickenstorfer K, Leeners B. Diurnal and seasonal changes in semen quality of men in subfertile partnerships. Chronobiol Int. 2018. 35(10):1375-1384. https://doi.org/10.1080/07420528.2018.1483942.
  18. Cagnacci A, Maxia N, Volpe A. Diurnal variation of semen quality in human males. Hum Reprod. 1999;14(1):106-109.
  19. Biljan MM, Tkalec DD, Lachgar H. Absence of diurnal variation in semen parameters in normospermic men. Fertil Steril. 2005;83(2):477-9. https://doi.org/10.1016/j.fertnstert.2004.10.026.
  20. Carlsen E, Olsson C, Petersen JH, et al. Diurnal rhythm in serum levels of inhibin B in normal men: relation to testicular steroids and gonadotropins. J Clin Endocrinol Metab.1999;84:1664-1669. https://doi.org/10.1210/jcem.84.5.5708.
  21. Jorgensen N, Liu F, Andersson AM, et al. Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: a coordinated study of 1,797 European and US men. Fertil Steril. 2010;94(6):2128-2134. https://doi.org/10.1016/j.fertnstert.2009.12.051.
  22. Hjollund NH, Storgaard L, Ernst E, et al. Impact of diurnal scrotal temperature on semen quality. Reprod Toxicol. 2002;16(3):215-221.
  23. Sharpe RM. Regulation of spermatogenesis. In: The Physiology of Reproduction. Ed by E. Knobil, J.D. Neill (eds). 2nd edn. New York: Raven Press; 1994. P. 1363-1434.
  24. Setchell BP, Maddocks S, Brooks DE. Anatomy, vasculature, innervation, and fluids of the male reproductive tract. In: The Physiology of Reproduction. Ed by E. Knobil, J.D. Neill (eds). 2nd edn. New York: Raven Press; 1994. P. 1063-1175.

Supplementary files

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2. Fig. 1. Ejaculate volume of sperm donors depending on the time of its collection

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3. Fig. 2. The quantity (millions) of sperm cells in the ejaculate, depending on the time of its collection

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4. Fig. 3. Average values of the proportion of progressively motile sperm (%) in the ejaculate of sperm donors

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Copyright (c) 2019 Korneyev I.A., Zasseev R.D., Pashina O.B., Mamedov A.E., Kondrashkin P.S., Krylov O.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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