Post-COVID syndrome in urological practice
- Authors: Kuzmenko A.V.1, Petrova D.A.1, Gyaurgiev T.А.1
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Affiliations:
- Burdenko Voronezh State Medical University
- Issue: Vol 12, No 3 (2022)
- Pages: 239-248
- Section: Reviews
- URL: https://journals.rcsi.science/uroved/article/view/109212
- DOI: https://doi.org/10.17816/uroved109212
- ID: 109212
Cite item
Abstract
This review article examines the impact of the SARS-CoV-2 coronavirus on the urinary system, as well as on men’s health. Data on aspects of pathogenesis and features of the course of a new coronavirus infection are presented. Possible risk factors for contracting a new coronavirus infection associated with an abundance of angiotensin-converting enzyme-2 (ACE2) receptors in the kidneys and urinary tract, to which SARS-CoV-2 has an affinity, are considered. The article provides an extensive range of studies that provide convincing evidence for the presence of changes in the spermogram of patients who have undergone COVID-19. Works demonstrating gender differences in the incidence of COVID-19 and concomitant diseases are presented. The literature review considers both direct and indirect factors (oxidative stress, cytokine storm, decreased libido), through which coronavirus infection negatively affects male sexual health.
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##article.viewOnOriginalSite##About the authors
Andrey V. Kuzmenko
Burdenko Voronezh State Medical University
Email: kuzmenkoav09@yandex.ru
ORCID iD: 0000-0002-7927-7015
SPIN-code: 6981-7490
Scopus Author ID: 7003998310
http://vrngmu.ru/academy/personnel/978/
Dr. Sci. (Med), Professor, Head of the Department of Urology
Russian Federation, 10, Studencheskaya st., Voronezh, 394036Daria A. Petrova
Burdenko Voronezh State Medical University
Email: dariapetrova.29.07@gmail.com
ORCID iD: 0000-0002-9640-1399
SPIN-code: 6536-2553
Student
Russian Federation, 10, Studencheskaya st., Voronezh, 394036Timur А. Gyaurgiev
Burdenko Voronezh State Medical University
Author for correspondence.
Email: tima001100@mail.ru
ORCID iD: 0000-0002-6261-3641
SPIN-code: 8050-7190
Cand. Sci. (Med.), Associate Professor of the Department of Urology
Russian Federation, 10, Studencheskaya st., Voronezh, 394036References
- WHO Director-General’s remarks at the media briefing on 2019-nCoV on 11 February 2020 (2020). [Internet] Available at: https://www.who.int/director-general/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020
- Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020;20(5):533–534. doi: 10.1016/S1473-3099(20)30120-1
- Shchelkanov MY, Popova AY, Dedkov VG, et al. History of investigation and current classification of coronaviruses (Nidovirales: Coronaviridae). Russian Journal of Infection and Immunity. 2020. Vol. 10, No. 2. P. 221–246. (In Russ.) doi: 10.15789/2220-7619-HOI-1412
- Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for disease control and prevention. JAMA. 2020;323(13):1239–1242. doi: 10.1001/jama.2020.2648
- Lauer SA, Grantz KH, Bi Q, et al. The Incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med. 2020;172(9):577–582. doi: 10.7326/M20-0504
- Khaitovich AB, Yermachkova PA. Coronaviruses (genome structure, replication). Crimean Journal of Experimental and Clinical Medicine. 2021;11(1):61–75 (In Russ.) doi: 10.37279/2224-6444-2021-11-1-61-75
- Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol. 2020;5(4):562–569. doi: 10.1038/s41564-020-0688-y
- Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–280.e8. doi: 10.1016/j.cell.2020.02.052
- Jin P, Park H, Jung S, Kim J. Challenges in urology during the COVID-19 pandemic. Urol Int. 2021;105(1–2):3–16. doi: 10.1159/000512880
- Zou X, Chen K, Zou J, et al. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020;14(2):185–192. doi: 10.1007/s11684-020-0754-0
- Chu KH, Tsang WK, Tang CS, et al. Acute renal impairment in coronavirus-associated severe acute respiratory syndrome. Kidney Int. 2005;67(2):698–705. doi: 10.1111/j.1523-1755.2005.67130.x
- Novitskiy AV, Chetverikov AV, Lankov VA, et al. COVID-19 associated incrusting cystitis. Experimental and Clinical Urology. 2021;14(4):108–112. (In Russ.) doi: 10.29188/2222-8543-2021-14-4-108-112
- Farsimadan M, Motamedifar M. Bacterial infection of the male reproductive system causing infertility. J Reprod Immunol. 2020;142:103183. doi: 10.1016/j.jri.2020.103183
- La Vignera S, Condorelli RA, Vicari E, et al. Microbiological investigation in male infertility: a practical overview. J Med Microbiol. 2014;63(Pt 1):1–14. doi: 10.1099/jmm.0.062968-0
- Dejucq N, Jégou B. Viruses in the mammalian male genital tract and their effects on the reproductive system. Microbiol Mol Biol Rev. 2001;65(2):208–231. doi: 10.1128/MMBR.65.2.208-231.2001
- Zhao S, Zhu W, Xue S, Han D. Testicular defense systems: immune privilege and innate immunity. Cell Mol Immunol. 2014;11(5): 428–437. doi: 10.1038/cmi.2014.38
- Wang Z, Xu X. scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, leydig and sertoli cells. Cells. 2020;9(4):920. doi: 10.3390/cells9040920
- Verma S, Saksena S, Sadri-Ardekani H. ACE2 receptor expression in testes: implications in coronavirus disease 2019 pathogenesis. Biol Reprod. 2020;103(3):449–451. doi: 10.1093/biolre/ioaa080
- Alkhatatbeh H, Alzaghari D, Alkhashman A, et al. Does severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cause orchitis in patients with coronavirus disease 2019 (COVID-19)? Arab J Urol. 2020;18(3):129–133. doi: 10.1080/2090598X.2020.1798862
- Chen L, Huang X, Yi Z, et al. Ultrasound imaging findings of acute testicular infection in patients with coronavirus disease 2019: a single-center-based study in Wuhan, China. J Ultrasound Med. 2021;40(9):1787–1794. doi: 10.1002/jum.15558
- Derevyanko TI, Pridchin SV. Hemorrhagic testicular infarction as a complication of COVID-19 (SARS-CoV-2) clinical case. Experimental and Clinical Urology, 2021;14(2):70–72. (In Russ.) doi: 10.29188/2222-8543-2021-14-2-70-72
- Patel DP, Punjani N, Guo J, et al. The impact of SARS-CoV-2 and COVID-19 on male reproduction and men’s health. Fertil Steril. 2021;115(4):813–823. doi: 10.1016/j.fertnstert.2020.12.033
- Liu X, Chen Y, Tang W, et al. Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes. Sci China Life Sci. 2020;63(7):1006–1015. doi: 10.1007/s11427-020-1705-0
- Xu J, Qi L, Chi X, et al. Orchitis: a complication of severe acute respiratory syndrome (SARS). Biol Reprod. 2006;74(2):410–416. doi: 10.1095/biolreprod.105.044776
- Flaifel A, Guzzetta M, Occidental M, et al. Testicular changes associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Arch Pathol Lab Med. 2021;145(1):8–9. doi: 10.5858/arpa.2020-0487-LE
- Rozenberg S, Vandromme J, Martin C. Are we equal in adversity? Does COVID-19 affect women and men differently? Maturitas. 2020;138:62–68. doi: 10.1016/j.maturitas.2020.05.009
- Berletch JB, Yang F, Xu J, et al. Genes that escape from X inactivation. Hum Genet. 2011;130(2):237–245. doi: 10.1007/s00439-011-1011-z
- Chen YW, Lee MS, Lucht A, et al. TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. Am J Pathol. 2010;176(6):2986–2996. doi: 10.2353/ajpath.2010.090665
- Ibishev KhS, Atadzhanova AT, Mamedov EA, Vasilyev ON. The significance of coronavirus infection in the development of reproductive and lower urinary tract lesions. Vestn Urol. 2021;9(2):125–131. (In Russ.) doi: 10.21886/2308-6424-2021-9-2-125-131
- Montopoli M, Zumerle S, Vettor R, et al. Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532). Ann Oncol. 2020;31(8): 1040–1045. doi: 10.1016/j.annonc.2020.04.479
- Aitken RJ, Roman SD. Antioxidant systems and oxidative stress in the testes. Oxid Med Cell Longev. 2008;1(1):15–24. doi: 10.4161/oxim.1.1.6843
- Selvaraj K, Ravichandran S, Krishnan S, et al. Testicular atrophy and hypothalamic pathology in COVID-19: possibility of the incidence of male infertility and HPG axis abnormalities. Reprod Sci. 2021;28(10):2735–2742. doi: 10.1007/s43032-020-00441-x
- Moghimi N, Eslami Farsani B, Ghadipasha M, et al. COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis. Apoptosis. 2021;26(7–8):415–430. doi: 10.1007/s10495-021-01680-2
- Döring N. How Is the COVID-19 pandemic affecting our sexualities? An overview of the current media narratives and research hypotheses. Arch Sex Behav. 2020;49(8):2765–2778. doi: 10.1007/s10508-020-01790-z
- Abbas AM, Fathy SK, Khamees AA, et al. A focused review on the genital and sexual affection of COVID-19 patients. J Gynecol Obstet Hum Reprod. 2020;49(8):101848. doi: 10.1016/j.jogoh.2020.101848
- Li G, Tang D, Song B, et al. Impact of the COVID-19 pandemic on partner relationships and sexual and reproductive health: cross-sectional, online survey study. J Med Internet Res. 2020;22(8):e20961. doi: 10.2196/20961