Email this article Assessment of the trace element blood condition in children with congenital deformities of the thoracic and lumbar spine (Preliminary report)
- Authors: Lobachevskaya T.V.1, Talova D.M.1, Sogoyan M.V.1, Ovechkina A.V.2
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Affiliations:
- The Turner Scientific Research Institute for Children’s Orthopedics
- The Turner Scientific Research Institute for Children’s Orthopedics, Saint Petersburg
- Issue: Vol 7, No 1 (2019)
- Pages: 51-56
- Section: Original papers
- URL: https://journals.rcsi.science/turner/article/view/11068
- DOI: https://doi.org/10.17816/PTORS7151-56
- ID: 11068
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Abstract
Introduction. Since the end of the last century, dysfunction of the trace element composition of blood in various forms of scoliosis has been an urgent problem in several studies. Hidden deficiency of trace elements, associated with insufficient food consumption or low absorption in the body, can cause progressive bone deformities. In this context, special importance is attached to trace elements, such as copper, selenium, zinc, boron, manganese, and others. The study of the trace element concentrations in patients with congenital spinal deformities currently is an important and significant task.
Aim. We assess the trace element composition of whole blood in children with congenital deformities of the thoracic and lumbar vertebral columns.
Materials and methods. We analyzed the trace element status of blood in 108 patients (aged 2–16 years) with congenital deformities of the thoracic and lumbar spine (CSD). The congenital vertebral anomalies included disorders of formation, fusion, and/or segmentation of the vertebrae. The control group consisted of 35 healthy children of identical age. Blood ethylenediaminetetraacetic acid (EDTA) was examined using mass spectrometry with inductively coupled plasma (ICP-MS ThermoScientific, iCAP RQ).
Results and discussion. The content of 33 essential and conditionally essential trace elements in the whole blood of patients with CSD was determined. In 37% of patients the zinc, copper, selenium, and chromium levels were decreased compared with the controls. In 7% and 89% of patients the selenium and of chromium levels, respectively, were especially low, below the sensitivity of the device.
Conclusion. The statistically significantly low content of zinc, copper, selenium, and chromium in the whole blood of patients with CSD may have a role in the pathogenesis of the disorders. Further investigations are needed to evaluate their importance as a marker of disease progression.
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##article.viewOnOriginalSite##About the authors
Tatiana V. Lobachevskaya
The Turner Scientific Research Institute for Children’s Orthopedics
Email: lobachevskayatatiyana@yahoo.com
ORCID iD: 0000-0002-1158-9573
MD, PhD, Assistant Professor, member of AACC, doctor of Clinical Laboratory Diagnostics of the Consultative Diagnostic Center
Russian Federation, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603Daria M. Talova
The Turner Scientific Research Institute for Children’s Orthopedics
Author for correspondence.
Email: dasha_talova@mail.ru
ORCID iD: 0000-0002-2627-5120
MD, doctor of Clinical Laboratory Diagnostics of the Consultative Diagnostic Center
Russian Federation, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603Marina V. Sogoyan
The Turner Scientific Research Institute for Children’s Orthopedics
Email: sogoyanmarina@mail.ru
MD, Research Associate of the Genetic Laboratory of the Center for Rare and Hereditary Diseases in Children
Russian Federation, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603Alla V. Ovechkina
The Turner Scientific Research Institute for Children’s Orthopedics, Saint Petersburg
Email: ovechkina.spb@mail.ru
ORCID iD: 0000-0002-3172-0065
MD, PhD, Associate Professor, Honored Doctor of the Russian Federation, Academic Secretary
Russian Federation, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603References
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