New opportunities of therapy of severe atopic dermatitis

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This article presents a case of the successful use of dupilumab in a 21-year-old patient with severe atopic dermatitis, concomitant bronchial asthma, and allergic rhinitis. The patient was observed in the allergological department of the Krasnoyarsk Clinical Regional Hospital for 2 years. The disease was characterized by constant skin symptoms, frequent exacerbations, resistance to standard therapy, including systemic glucocorticosteroids and immunosuppressors. Considering the above factors, targeted therapy was started with dupilumab, registered in the Russian Federation for use in atopic dermatitis resistant to standard therapy. Against the background of biological therapy (13 injections were carried out), a stable significant decrease in skin syndrome activity was achieved (SCORAD index decreased from 72 to 9 points), and the patient’s quality of life significantly improved.

作者简介

Irina Demko

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital

Email: demko64@mail.ru
ORCID iD: 0000-0001-8982-5292
SPIN 代码: 6520-3233

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, 1, Partizan Zheleznyak str., Krasnoyarsk, 660022; Krasnoyarsk

Elena Sobko

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital

Email: sobko29@mail.ru
ORCID iD: 0000-0002-9377-5213
SPIN 代码: 9132-6756

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, 1, Partizan Zheleznyak str., Krasnoyarsk, 660022; Krasnoyarsk

Angelina Kraposhina

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital

编辑信件的主要联系方式.
Email: angelina-maria@inbox.ru
ORCID iD: 0000-0001-6896-877X
SPIN 代码: 8829-9240

MD, Cand. Sci. (Med.), Associate Professor

俄罗斯联邦, 1, Partizan Zheleznyak str., Krasnoyarsk, 660022; Krasnoyarsk

Natalia Shestakova

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital

Email: barsk@rambler.ru
ORCID iD: 0000-0002-2252-7423
SPIN 代码: 4579-4502

MD, Cand. Sci. (Med.)

俄罗斯联邦, 1, Partizan Zheleznyak str., Krasnoyarsk, 660022; Krasnoyarsk

Natalia Gordeeva

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital

Email: natagorday@yandex.ru
ORCID iD: 0000-0002-0586-8349
SPIN 代码: 7914-7630

MD, Cand. Sci. (Med.), Associate Professor

俄罗斯联邦, 1, Partizan Zheleznyak str., Krasnoyarsk, 660022; Krasnoyarsk

Karina Kasymova

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: ayaneshiroi@gmail.com
ORCID iD: 0000-0001-8448-6113
SPIN 代码: 4691-2399

MD

俄罗斯联邦, 1, Partizan Zheleznyak str., Krasnoyarsk, 660022

参考

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