Effect of hypovitaminosis D on the activity of chronic spontaneous urticaria

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The aim of the study. To study the effect of hypovitaminosis D on the activity of CSU and the clinical efficacy of cholecalciferol in the complex therapy of patients with different baseline level of vitamin D metabolites. Methods. 48 CSU patients were included in the study - 20 patients in the main group, 28 in the comparison group. The control group consisted of 26 healthy donors. Patients with CSU of the main group regardless of the initial level of vitamin D were treated with non sedative antihistamines and an aqueous solution of cholecalciferol (vitamin D3) at the dosage of 10,000 units/day. The course of treatment with cholecalciferol was 4 weeks. The concentration of 25(OH)D and 1,25(OH)2D was determined in the blood serum of patients before and after the treatment and in control group. The diagnosis of hypovitaminosis D was carried out on the basis of 25(OH)D concentrations <30 ng/ml. The activity of CSU was assessed by the indicators of the urticaria activity score UAS-7. Results. Hypovitaminosis D occurs with the same frequency in patients with CSU and in control group. At the same time, the activity of CSU in patients with hypovitaminosis D is significantly higher than in patients with normal vitamin D levels, as evidenced by UAS-7 (respectively 24.3±13.68 and 17.5±8.1; p<0.05). A negative correlation was found between the activity of CSU and the concentration of 25(OH)D in patients with hypovitaminosis D. Correction of hypovitaminosis D with an aqueous solution of cholecalciferol at a dosage of 10,000 units/day during 4 weeks with simultaneous basic therapy with non sedative antihistamines leaded to a reliable decrease of UAS-7, however, complete control of the disease did not occured. In patients with an initially normal level of 25(OH)D, an additional administration of vitamin D therapy does not lead to significant changes of UAS-7. The concentration of 1,25(OH)2D in the blood serum of patients with CSU did not depend on the presence or absence of hypovitaminosis D and did not change on cholecalciferol therapy.

作者简介

A Vitchuk

Smolensk State Medical University

Email: Djonnyfunt@mail.ru
ассистент кафедры клинической иммунологии и аллергологии

N Kovrigina

Smolensk State Medical University

ассистент кафедры клинической иммунологии и аллергологии

S Aksenova

Smolensk State Medical University

кандидат медицинских наук

E Slabkaya

Smolensk State Medical University

кандидат медицинских наук

E Volkova

Smolensk Regional Department of Allergy and Clinical Immunology

зав. Смоленским областным центром аллергологии и иммунологии

V Bityutskaya

Smolensk Regional Department of Allergy and Clinical Immunology

центр аллергологии и иммунологии, врач аллерголог-иммунолог. Смоленск

R Meshkova

Smolensk State Medical University

доктор медицинских наук, профессор

参考

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