Лекарственная анафилаксия: распространенность, факторы риска, триггеры

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Повсеместное увеличение частоты анафилаксии в целом сопровождается тенденцией к повышению распространенности и лекарственной анафилаксии. Лекарственные препараты занимают лидирующую позицию среди причин развития анафилактических реакций у взрослой группы пациентов и второе место у детей. При этом наиболее значимыми являются нестероидные противовоспалительные средства, антибактериальные препараты и рентгеноконтрастные вещества. Риск развития лекарственной анафилаксии в большинстве случаев непредсказуем, причем частота тяжелых и летальных реакций крайне высока. В настоящей статье представлен анализ современных данных о распространенности, возможных факторах риска и триггерах лекарственной анафилаксии.

Об авторах

Наталья Владиславовна Есакова

ОСП «Научно-исследовательский клинический институт педиатрии имени академика Ю.Е. Вельтищева» ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России

Email: env007@rambler.ru
к.м.н., научный сотрудник отдела аллергологии и клинической иммунологии

Александр Николаевич Пампура

ОСП «Научно-исследовательский клинический институт педиатрии имени академика Ю.Е. Вельтищева» ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России

доктор медицинских наук, зав. отделом аллергологии и клинической иммунологии

Список литературы

  1. Sampson HA, Munoz-Furlong A, Campbell RL, Adkinson NF, Bock SA, Branum A et al. Second symposium on the definition and management of anaphylaxis: summary report - Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006;117:391-397. DOI: 10.1016/j. jaci.2005.12.1303.
  2. Montanez MI, Mayorga C, Bogas G, Barrionuevo E, Fernandez-Santamaria R et al. Epidemiology, Mechanisms, and Diagnosis of Drug-Induced Anaphylaxis. Front Immunol. 2017;8:614. doi: 10.3389/fimmu.2017.00614.
  3. Liew WK, Williamson E, Tang ML. Anaphylaxis fatalities and admissions in Australia. J Allergy Clin Immunol. 2009;123(2):434-442. doi: 10.1016/j.jaci.2008.10.049.
  4. Jerschow E, Lin RY, Scaperotti MM, McGinn AP. Fatal anaphylaxis in the United States, 1999-2010: temporal patterns and demographic associations. J Allergy Clin Immunol. 2014;134(6):1318-1328. doi: 10.1016/j.jaci.2014.08.018.
  5. Wood RA, Camargo CA Jr, Lieberman P, Sampson HA, Schwartz LB, Zitt M et al. Anaphylaxis in United States: the prevalence and characteristics of anaphylaxis in the United States. J Allergy Clin Immunol. 2014;133(2):461-467. doi: 10.1016/j.jaci.2013.08.016.
  6. Huang F, Chawla K, Jarvinen KM, Nowak-Węgrzyn A. Anaphylaxis in a New York City pediatric emergency department: triggers, treatments, and outcomes. J Allergy Clin Immunol. 2012;129(1):162-168. doi: 10.1016/j.jaci.2011.09.018
  7. Clark S, Wei W, Rudders SA, Camargo CA Jr. Risk factors for severe anaphylaxis in patients receiving anaphylaxis treatment in US emergency departments and hospitals. J Allergy Clin Immunol. 2014;134(5):1125-1130. DOI: 10.1016/j. jaci.2014.05.018.
  8. Brown SG, Stone SF, Fatovich DM, Burrows SA, Holdgate A, Celenza A. Anaphylaxis: clinical patterns, mediator release, and severity. J Allergy Clin Immunol. 2013;132(5):1141-1149. doi: 10.1016/j.jaci.2013.06.015.
  9. Banerji A, Rudders S, Clark S, Wei W, Long AA, Camargo CA Jr. Retrospective study of drug-induced anaphylaxis treated in the emergency department or hospital: patient characteristics, management, and 1-year follow-up. J Allergy Clin Immunol Pract. 2014;2(1):46-51. doi: 10.1016/j.jaip.2013.08.012.
  10. Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM. Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. Crit Rev Clin Lab Sci. 2003;40(6):643-672. doi: 10.1080/714037693.
  11. Vadas P, Gold M, Liss G, Smith C, Yeung J. PAF acetylhy-drolase deficiency predisposes to fatal anaphylaxis. J Allergy Clin Immunol. 2003;11:S206.
  12. Vadas P, Perelman B, Liss G. Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. J Allergy Clin Immunol. 2013;131:144-149. DOI: 10.1016/j. jaci.2012.08.016.
  13. Brown SG, Stone SF, Fatovich DM, Burrows SA, Holdgate A, Celenza A. Anaphylaxis: clinical patterns, mediator release, and severity. J Allergy Clin Immunol. 2013;132(5):1141-1149. doi: 10.1016/j.jaci.2013.06.015.
  14. Kruse S, Mao XQ, Heinzmann A, Blattmann S, Roberts MH, Braun S. The Ile198Thr and Ala379Val variants of plasmatic PAF-Acetylhydrolase impair catalytical activities and are associated with atopy and asthma. Am J Hum Genet. 2000;66(5):1522-1530. doi: 10.1086/302901.
  15. Esakova NV, Saakyan EK, Kondratieva NS, Kokaeva ZG, Nesterova AP, Golovatenko-Abramov PK et al. Platelet-Activating Factor-Acetylhydrolase Gene (PLA2G7) Expression in Children with a History of Food Anaphylaxis. J Allergy Ther. 2015;6:211. doi: 10.4172/2155-6121.1000211.
  16. Bertelsen K, Dalgaard JB. Death due to penicillin. 16 Danish cases with autopsies. Nord Med. 1965;73:173-177.
  17. Idsoe O, Guthe T, Willcox RR, de Weck AL. Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock. Bull World Health Organ. 1968;38(2):159-188.
  18. Bonadonna P, Pagani M, Aberer W, Bilo MB, Brockow K, Oude Elberink H et al. Drug hypersensitivity in clonal mast cell disorders: ENDA/EAACI position paper. Allergy. 2015;70(7):755-763. doi: 10.1111/all.12617.
  19. Lang DM, Alpern MB, Visintainer Pf, Smith ST Elevated risk of anaphylactoid reaction from radiographic contrast media is associated with both beta-blocker exposure and cardiovascular disorders. Arch Intern Med. 1993;153(17):2033-2040.
  20. Nassiri M, Babina M, Dolle S, Edenharter G, Rueff F, Worm M. Ramipril and metoprolol intake aggravate human and murine anaphylaxis: evidence for direct mast cell priming. J Allergy Clin Immunol. 2015;135(2):491-499. DOI: 10.1016/j. jaci.2014.09.004.
  21. Stoevesandt J, Hain J, Stolze I, Kerstan A, Trautmann A. Angiotensin-converting enzyme inhibitors do not impair the safety of Hymenoptera venom immunotherapy build-up phase. Clin Exp Allergy. 2014;44(5):747-755. DOI: 10.1111/ cea.12276.
  22. Ramirez E, Cabanas R, Laserna LS, Fiandor A, Tong H, Prior N. Proton pump inhibitors are associated with hyper sensitivity reactions to drugs in hospitalized patients: a nested casecontrol in a retrospective cohort study. Clin Exp Allergy. 2013;43(3):344-352. doi: 10.1111/cea.12034.
  23. Kuruvilla M, Khan DA. Anaphylaxis to drugs. Immunol Allergy Clin North Am. 2015;35(2):303-319. DOI: 10.1016/j. iac.2015.01.008.
  24. Blanca-Lopez N, Soriano V, Garcia-Martin E, Canto G, Blanca M. NSAID-induced reactions: classification, prevalence, impact, and management strategies. J Asthma Allergy. 2019;12:217-233. doi: 10.2147/JAA.S164806.
  25. Riemer AB, Gruber S, Pali-Scholl I, Kinaciyan T, Untersmayr E, Jensen-Jarolim E. Suppression of gastric acid increases the risk of developing immunoglobulin E-mediated drug hypersensitivity: human diclofenac sensitization and a murine sensitization model. Clin Exp Allergy. 2010;40(3):486-493. doi: 10.1111/j.1365-2222.2009.03363.x.
  26. Himly M, Jahn-Schmid B, Pittertschatscher K, Pittertschatscher K, Bohle B, Grubmayr K et al. IgE-mediated immediate-type hypersensitivity to the pyrazolone drug pro-pyphenazone. J Allergy Clin Immuno.l 2003;111(4):882-888. doi: 10.1067/mai.2003.163.
  27. Quiralte J, Blanco C, Delgado J, Ortega N, Acntara M, Castillo R et al. Challenge-based clinical patterns of223 Spanish patients with nonsteroidal anti-inflammatory-drug-induced-re-actions. J Investig Allergol Clin Immunol. 2007;17(3):182-188.
  28. Gonzalez-Perez A, Aponte Z, Vidaurre CF, Garcia Rodriguez LA. Anaphylaxis epidemiology in patients with and patients without asthma: a United Kingdom database review. J Allergy Clin Immunol. 2010;125(5):1098-1104.
  29. Weiss ME, Adkinson NF. Immediate hypersensitivity reactions to penicillin and related antibiotics. Clin Allergy. 1988;18(6):515-540. doi: 10.1111/j.1365-2222.1988. tb02904.x.
  30. Neugut AI, Ghatak AT, Miller RL. Anaphylaxis in the United States: an investigation into its epidemiology. Arch Intern Med. 2001;161(1):15-21. doi: 10.1001/archinte.161.1.15.
  31. Levine BB, Zolov DM. Prediction of penicillin allergy by immunological tests. J Allergy. 1969;43(4):231-244. doi: 10.1016/0021-8707(69)90066-5.
  32. Macy E, Ngor EW Safely diagnosing clinically significant penicillin allergy using only penicilloyl-poly-lysine, penicillin, and oral amoxicillin. J Allergy Clin Immunol Pract. 2013;1:258-263. doi: 10.1016/j.jaip.2013.02.002.
  33. Blanca M, Torres MJ, Garcia JJ, Romano A, Mayorga C, de Ramon E et al. Natural evolution of skin test sensitivity in patients allergic to beta-lactam antibiotics. J Allergy Clin Immunol. 1999;103(5 Pt 1):918-924. doi: 10.1016/s0091-6749(99)70439-2.
  34. Torres MJ, Ariza A, Mayorga C, Dona I, Blanca-Lopez N, Rondon C et al. Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions. J Allergy Clin Immunol. 2010;125(2):502-505. doi: 10.1016/j.jaci.2009.11.032.
  35. Romano A, Gueant-Rodriguez RM, Viola M, Amoghly F, Gaeta F, Nicolas JP et al. Diagnosing immediate reactions to cephalosporins. Clin Exp Allergy. 2005;35(9):1234-1242. doi: 10.1111/j.1365-2222.2005.02317.x.
  36. Chen Z, Baur X, Kutscha-Lissberg F, Merget R. IgE-mediated anaphylactic reaction to imipenem. Allergy. 2000;55(1):92-93. doi: 10.1034/j.1398-9995.2000.00360.x.
  37. Iglesias Cadarso A, Saez Jimenez SA, Vidal Pan C, Rodriguez Mosquera M. Aztreonam-induced anaphylaxis. Lancet. 1990;336(8717):746-747. doi: 10.1016/0140-6736(90)92238-d.
  38. Romano A, Viola M, Gueant-Rodriguez RM, Gaeta F, Valluzzi R, Gueant JL. Brief communication: tolerability of meropenem in patients with IgE-mediated hypersensitivity to penicillins. Ann Intern Med. 2007;146(4):266-269. doi: 10.7326/0003-4819-146-4-200702200-00005.
  39. Romano A, Gaeta F, Valluzzi RL, Caruso C, Rumi G, Bousquet PJ. IgE-mediated hypersensitivity to cephalosporins: cross-reactivity and tolerability of penicillins, monobactams, and carbapenems. J Allergy Clin Immunol. 2010;126(5):994-999.
  40. Bijl AM, Van der Klauw MM, Van Vliet AC, Stricker BH. Anaphylactic reactions associated with trimethoprim. Clin Exp Allergy. 1998;28(4):510-512. doi: 10.1046/j.1365-2222.1998.00258.x.
  41. Swamy N, Laurie SA, Ruiz-Huidobro E, Khan DA. Successful clarithromycin in a multiple macrolid e-allergic patient. Ann Allergy Asthma Immunol. 2010;105(6):489-490.
  42. Renaudin JM, Beaudouin E, Ponvert C, Demoly P, Moneret-Vautrin DA. Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010. Allergy. 2013;68(7):929-937. doi: 10.1111/all.12168.
  43. Blanca-Lopez N, Ariza A, Dona I, Mayorga C, Montanez MI. Hypersensitivity reactions to fluoroquinolones: analysis of the factors involved. Clin Exp Allergy. 2013;43(5):560-567.
  44. Wong JT, Ripple RE, MacLean JA, Marks DR, Bloch KJ. Vancomycin hypersensitivity: synergism with narcotics and “desensitization” by a rapid continuous intravenous protocol. J Allergy Clin Immunol. 1994;94(2): 189-194. doi: 10.1016/0091-6749(94)90039-6.
  45. Kim MH, Lee SY, Lee SE, Yang MS, Jung JW, Park CM et al. Anaphylaxis to iodinated contrast media: clinical characteristics related with development of anaphylactic shock. PLoS One. 2014;9(6):e100154. doi: 10.1371/journal.pone.0100154.
  46. Brockow K, Romano A, Aberer W, Bircher AJ, Barbaud A, Bonadonna P et al. Skin testing in patients with hypersensitivity reactions to iodinated contrast media - a European multicenter study. Allergy. 2009;64(2):234-241. doi: 10.1111/j.1398-9995.2008.01832.x.
  47. Jung JW, Kang HR, Kim MH, Lee W, Min KU, Han MH et al. Immediate hypersensitivity reaction to gadolinium-based MR contrast media. Radiology. 2012;264(2):414-422. doi: 10.1148/radiol.12112025.
  48. Greenberger PA, Patterson R, Radin RC. Two pretreatment regimens for high-risk patients receiving radiographic contrast media. J Allergy Clin Immunol. 1984;74(4):540-543. doi: 10.1016/0091-6749(84)90391-9.
  49. Davenport MS, Cohan RH, Caoili EM, Ellis JH. Repeat contrast medium reactions in premedicated patients: frequency and severity. Radiology. 2009;253(2):372-379. DOI: 10.1148/ radiol.2532090465.
  50. Gandhi S, Litt D, Chandy M, Nguyen BM, Jindal NL, Tarlo SM et al. Successful rapid intravenous desensitization for radioiodine contrast allergy in a patient requiring urgent coronary angiography. J Allergy Clin Immunol Pract. 2014;2(1):101-102. doi: 10.1016/j.jaip.2013.06.016.
  51. Harle Dg, Baldo BA, Coroneos Nj, Fisher MM. Anaphylaxis following administration of papaveretum. Case report: implication of IgE antibodies that react with morphine and codeine, and identification of an allergenic determinant. Anesthesiology. 1989;71(4):489-494.
  52. Gonzalez P, de la Sen ML, Venegas I, Ramon A, Soriano V, Cueva B et al. Immediate hypersensitivity to heparins: a cross-reactivity study. J Investig Allergol Clin Immunol. 2014;24(5):367-368.
  53. Kishimoto TK, Viswanathan K, Ganguly T, Elankumaran S, Smith S, Pelzer K et al. Contaminated heparin associated with adverse clinical events and activation of the contact system. N Engl J Med. 2008;358(23):2457-2467. doi: 10.1056/NE-JMoa0803200.
  54. Dona I, Blanca-Lopez N, Torres MJ, Garcia-Campos J, Garcia-Nunez I, Gomez F et al. Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients. J Investig Allergol Clin Immunol. 2012;22(5):363-371.
  55. Bonadonna P, Lombardo C, Bortolami O, Bircher A, Scherer K, Barbaud A et al. Hypersensitivity to proton pump inhibitors: diagnostic accuracy of skin tests compared to oral provocation test. J Allergy Clin Immunol. 2012;130(2):547-549. doi: 10.1016/j.jaci.2012.04.048.
  56. Mertes PM, Alla F, Trechot P, Auroy Y, Jougla E; Groupe d’Etudes des Reactions Anaphylactoides Peranesthesiques. Anaphylaxis during anes-thesia in France: an 8 year national survey. J Allergy Clin Immunol. 2011;128(2):366-373. doi: 10.1016/j.jaci.2011.03.003.
  57. Laxenaire MC. Epidemiology of anesthetic anaphylactoid reactions. Fourth multicenter survey (July 1994 - December 1996). Ann Fr Anesth Reanim. 1999;18(7):796-809. doi: 10.1016/S0750-7658(00)88460-9.
  58. Janas-Naze A, Osica P. The incidence of lidocaine allergy in dentists: an evaluation of 100 general dental practitioners. Int J Occup Med Environ Health. 2019;32(3):333-339. doi: 10.13075/ijomeh.1896.01235.
  59. Berkun X Ben-Zvi A, Levy X Galili D, Shalit M. Evaluation of adverse reactions to local anesthetics: Experience with 236 patients. Ann Allergy Asthma Immunol. 2003;91:342-345.
  60. Laxenaire MC, Charpentier C, Feldman L. Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors, mechanisms. A French multicenter prospective study. Ann Fr Anesth Reanim. 1994;13(3):301-310. doi: 10.1016/S0750-7658(94)80038-3.

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