Immunomodulatory effect of hemozoin from Opisthorchis felineus and its participation in reducing allergic inflammation through activation of the inflammasome
- Authors: Melenteva A.P.1, Parshutkina T.A.1, Ogorodova L.M.1, Fedorova O.S.1
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Affiliations:
- Siberian State Medical University
- Issue: Vol 21, No 2 (2024)
- Pages: 295-304
- Section: Reviews
- URL: https://journals.rcsi.science/raj/article/view/260063
- DOI: https://doi.org/10.36691/RJA16930
- ID: 260063
Cite item
Abstract
Molecules of the excretory-secretory product arising as a result of co-evolution of a host and a parasite are able to inhibit the type 2 immune response, while activating the type 1 and the type 17 responses. The ability to alter the immune response can be used to inhibit inflammation in allergic diseases. In this regard, a search for helminth-associated molecules both with an immunomodulatory effect and immunogenicity and low toxicity is represented as a topical task.
Hemozoin being a dark brown insoluble biocrystal is an excretory product of a number of hematophagous parasites (Schistosoma mansoni, Plasmodium falciparum and Opisthorchis felineus). This substance as a compound of parasitic origin with explicit immunomodulatory properties has prospects for deep research.
Lots of relevant literature has been studied carefully before developing a concept about Opisthorchis felineus hemozoin and its unique properties.
Thus, the current review presents an analysis of the accumulated data regarding the effect of Opisthorchis felineus trematode on the host immune system. Also the data on the immunomodulatory effect of hemozoin of various origins is analyzed. The current knowledge on the immune mechanisms of inflammasome activation and the possible role of hemozoin in reducing allergic inflammation through this mechanism is represented in this article.
According to the systemized research results the excretory-secretory molecule of the liver fluke is a product of parasitic origin with an explicit immunomodulatory effect which is promising for prospective scientific study. Opisthorchis felineus extract increases the expression of T-regulatory cells and inhibits the Th2-immune response.
Hemozoin produced by Opisthorchis felineus, like one produced by Plasmodium falciparum, may be involved in reducing the activity of allergic inflammation through activation of the inflammasome. Comprehension of the mechanism of how hemozoin interacts with the host immune system can be applied for correction of conditions associated with Th2-polarization of the immune response, which primarily include atopic diseases.
Studying the mechanism of inflammation will help by the search for a biological target to create a vaccine to prevent the spread of atopic diseases, including bronchial asthma.
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##article.viewOnOriginalSite##About the authors
Anasyasiay P. Melenteva
Siberian State Medical University
Author for correspondence.
Email: anastasiaymelenteva@gmail.com
ORCID iD: 0009-0009-5600-5760
Russian Federation, Tomsk
Tamara A. Parshutkina
Siberian State Medical University
Email: tamara.parshutkina@gmail.com
ORCID iD: 0009-0008-3948-3608
Russian Federation, Tomsk
Ludmila M. Ogorodova
Siberian State Medical University
Email: edu@tomsk.gov.ru
ORCID iD: 0000-0002-2962-1076
MD, Dr. Sci. (Med.), Professor, corresponding member of the Russian Academy of Sciences
Russian Federation, TomskOlga S. Fedorova
Siberian State Medical University
Email: olga.sergeevna.fedorova@gmail.com
ORCID iD: 0000-0002-7130-9609
SPIN-code: 5285-4593
MD, Dr. Sci. (Med.)
Russian Federation, TomskReferences
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