Leukotriene receptor antagonists in the treatment of bronchial asthma: Consensus agreement “Bronchial Asthma and LEukoTriene receptor antagonists (BALET)”
- Authors: Avdeev S.N.1,2, Geppe N.A.1, Ilina N.I.3, Demko I.V.4, Zhestkov A.V.5, Zaitseva O.V.6, Kondyurina E.G.7, Kukes I.V.8, Kurbacheva O.M.3, Malakhov A.B.1, Mizernitsky Y.L.9, Nenasheva N.M.10, Pampura A.N.9,10, Revyakina V.A.11
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Affiliations:
- First Sechenov Moscow State Medical University (Sechenov university)
- Pulmonology scientific Research Institute under Federal Medical and Biological Agency of Russian Federation
- National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
- Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
- Samara State Medical University
- Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
- Novosibirsk State Medical University
- International Association of Clinical Pharmacologists and Pharmacists
- The Russian National Research Medical University named after N.I. Pirogov
- Russian Medical Academy of Continuous Professional Education
- Federal Research Center of Nutrition, Biotechnology and Food Safety
- Issue: Vol 20, No 2 (2023)
- Pages: 130-142
- Section: Clinical practice guidelines
- URL: https://journals.rcsi.science/raj/article/view/253516
- DOI: https://doi.org/10.36691/RJA7530
- ID: 253516
Cite item
Abstract
Under the auspices of the Russian Association of Allergists and Clinical Immunologists and the Russian Pediatric Respiratory Society, an expert meeting on “Leukotriene receptor antagonists in the treatment of bronchial asthma” was held.
Asthma is a common noncommunicable chronic disorder of the airways, characterized by variable and recurring symptoms, airflow obstruction, bronchial hyper-responsiveness, and underlying inflammation.
The creation and widespread use of inhaled corticosteroids and other innovative classes of drugs for treating bronchial asthma have remarkably affected the ability to achieve control over the course of the disease. Regardless, in most European countries, more than half of patients with bronchial asthma have suboptimal disease control. Recently, a class of leukotriene receptor blockers that contribute to the suppression of chronic allergic inflammation in patients with asthma has been actively studied. The majority of studies confirmed the usefulness of montelukast as monotherapy and as an add-on therapy to inhaled corticosteroids in mild to moderate asthma across all age groups. However, experts noted that in practical medicine, healthcare providers continuously inquire about the effectiveness and safety of this class of medicines in patients with bronchial asthma.
In this consensus document, the experts considered the importance of providing an answer to several topical questions regarding the use of antileukotriene therapy in clinical practice.
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##article.viewOnOriginalSite##About the authors
Sergey N. Avdeev
First Sechenov Moscow State Medical University (Sechenov university); Pulmonology scientific Research Institute under Federal Medical and Biological Agency of Russian Federation
Email: serg_avdeev@list.ru
ORCID iD: 0000-0002-5999-2150
SPIN-code: 1645-5524
MD, Dr. Sci. (Med.), Professor, Academic of the Russian Academy of Sciences
Russian Federation, Moscow; MoscowNatalia A. Geppe
First Sechenov Moscow State Medical University (Sechenov university)
Email: geppe@mail.ru
ORCID iD: 0000-0003-0547-3686
SPIN-code: 9916-0204
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowNatalia I. Ilina
National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
Author for correspondence.
Email: instimmun@yandex.ru
ORCID iD: 0000-0002-3556-969X
SPIN-code: 6715-5650
MD, Dr. Sci. (Med.), Professor
Russian Federation, 24 Kashirskoe shosse, 115522 MoscowIrina V. Demko
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Email: demko64@mail.ru
ORCID iD: 0000-0001-8982-5292
SPIN-code: 6520-3233
MD, Dr. Sci. (Med.), Professor
Russian Federation, KrasnoyarskAlexander V. Zhestkov
Samara State Medical University
Email: avzhestkov2015@yandex.ru
ORCID iD: 0000-0002-3960-830X
SPIN-code: 2765-9617
MD, Dr. Sci. (Med.), Professor
Russian Federation, SamaraOlga V. Zaitseva
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Email: olga6505963@yandex.ru
ORCID iD: 0000-0003-4530-553X
SPIN-code: 3090-4876
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowElena G. Kondyurina
Novosibirsk State Medical University
Email: condur@ngs.ru
ORCID iD: 0000-0003-3250-3107
SPIN-code: 8665-9138
MD, Dr. Sci. (Med.), Professor
Russian Federation, NovosibirskIlya V. Kukes
International Association of Clinical Pharmacologists and Pharmacists
Email: ilyakukes@gmail.com
ORCID iD: 0000-0003-1449-8711
SPIN-code: 1166-3569
MD, Cand. Sci. (Med.)
Russian Federation, MoscowOksana M. Kurbacheva
National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
Email: kurbacheva@gmail.com
ORCID iD: 0000-0003-3250-0694
SPIN-code: 5698-6436
MD, Dr. Sci. (Med.), Professor
Russian Federation, 24 Kashirskoe shosse, 115522 MoscowAleksandr B. Malakhov
First Sechenov Moscow State Medical University (Sechenov university)
Email: alexis4591m@mail.ru
ORCID iD: 0000-0002-2686-8284
SPIN-code: 1749-0503
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowYury L. Mizernitsky
The Russian National Research Medical University named after N.I. Pirogov
Email: yulmiz@mail.ru
ORCID iD: 0000-0002-0740-1718
SPIN-code: 6135-5260
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowNatalya M. Nenasheva
Russian Medical Academy of Continuous Professional Education
Email: 1444031@gmail.com
ORCID iD: 0000-0002-3162-2510
SPIN-code: 3363-6170
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowAlexander N. Pampura
The Russian National Research Medical University named after N.I. Pirogov; Russian Medical Academy of Continuous Professional Education
Email: pampura1@mail.ru
ORCID iD: 0000-0001-5039-8473
SPIN-code: 9722-7961
MD, Dr. Sci. (Med.), Professor
Russian Federation, Moscow; MoscowVera A. Revyakina
Federal Research Center of Nutrition, Biotechnology and Food Safety
Email: 5356797@mail.ru
ORCID iD: 0000-0002-1149-7927
SPIN-code: 4607-0540
MD, Dr. Sci. (Med.), Professor
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