Immunobiological therapy of psoriasis: current state of the problem

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Abstract

Psoriasis remains one of the most prominent dermatological diseases and is not limited only to skin manifestations, but often affects internal organs, is burdened by the presence of polymorbid pathology.

Over time, the processes of understanding the mechanisms, diagnosis and treatment of this disease are evolving, and approaches to patient management are being improved. Both external treatment methods and systemic therapy are widely used. Against the background of an actively growing range of drugs used to treat psoriasis, it is quite difficult to make an individual choice for each individual patient, therefore, the most important area of scientific research is to find starting points for personalized therapy selection.

The use of genetically engineered biological drugs to influence certain parts of the immunopathological process is the most advanced line of therapy for psoriasis today. By inhibiting the corresponding proinflammatory cytokines, cellular signaling can be altered and, thus, further pathways of the inflammatory process can be inhibited.

About the authors

Antonina A. Arsenyeva

Samara State Medical University

Author for correspondence.
Email: a.a.arseneva@samsmu.ru
ORCID iD: 0000-0002-7933-3515
SPIN-code: 4320-1196

MD, Cand. Sci. (Medicine), Assistant Professor

Russian Federation, Samara

Natalia B. Migacheva

Samara State Medical University

Email: n.b.migacheva@samsmu.ru
ORCID iD: 0000-0003-0941-9871
SPIN-code: 1313-9021

MD, Dr. Sci. (Medicine), Assistant Professor

Russian Federation, Samara

Artem V. Lyamin

Samara State Medical University

Email: a.v.lyamin@samsmu.ru
ORCID iD: 0000-0002-5905-1895
SPIN-code: 6607-8990

MD, Dr. Sci. (Medicine), Assistant Professor

Russian Federation, Samara

Dmitry P. Kurmaev

Samara State Medical University

Email: geriatry@mail.ru
ORCID iD: 0000-0003-4114-5233
SPIN-code: 2179-5831

Cand. Sci. (Medicine)

Russian Federation, Samara

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