Allergocomponent diagnostics in the management of comorbid patients

Molecular allergy diagnostics is indicated for patients with comorbid allergy pathology and established polyvalent sensitization. Polyvalent sensitization (simultaneous formation of specific antibodies to allergens from several sources, for example, to cat allergens, birch pollen allergens, strawberries) can manifest itself at any age and is observed in a significant number of patients with allergic diseases. In patients with polyvalent sensitization and / or cross-reactions to allergens of unrelated groups of allergens, the diagnostic search for the causative allergen is difficult. In such cases, molecular allergy diagnostics allows you to establish the spectrum of true sensitization, make a reasonable choice of pathogenetic therapy, predict the course of an allergic disease, prevent the development of severe systemic reactions, including anaphylaxis, carry out reasonable elimination measures in relation to food allergens, preserving the maximum set of nutrients in the patient’s diet. We have carried out work to identify polyvalent sensitization in patients using the ALEX2 allergy chip, recognized as an advanced method of multicomponent allergy diagnostics, which in one study detects specific antibodies to 300 allergens (120 allergens and 180 allergenic molecules) and determines the concentration of total immunoglobulin E (IgE) in the blood serum. The presented clinical examples demonstrate the high information content of the ALEX2 technology, clearly show the possibility of determining the spectrum of causative allergens, which subsequently determines the appointment of adequate treatment and prevents the development of complications, especially in comorbid patients. Allergy component diagnostics provides extensive and detailed information about the patient’s sensitization profile at the molecular level, makes it possible to predict urgent allergic reactions, as well as assess the effectiveness of ASIT and develop personalized recommendations for patients with allergic diseases and polyvalent sensitization to various allergens. The accumulated clinical data indicate the need for a comprehensive diagnostic and therapeutic approach to the management of comorbid patients with allergopathology, which significantly increases the effectiveness of treatment and the quality of life of this category of patients. Molecular allergy diagnostics is an important tool in the hands of an allergist, which plays a significant role not only in current scientific research, but also in everyday clinical work.