Clinical and epidemiological features of cutaneous mastocytosis among the pediatric population of Moscow

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

BACKGROUND: Cutaneous mastocytosis is a rare disease that primarily develops in childhood.

AIM: This study aimed to determine the clinical and epidemiological characteristics and frequency of detection of cutaneous mastocytosis among children in Moscow.

MATERIALS AND METHODS: A single-center epidemiological retrospective study was conducted. Data from Form № 12 of the federal statistical observation "Information on the number of diseases registered in patients living in the service area of a medical organization" were used as a statistical source of information. To calculate the incidence rate in intensive indicators per 100 thousand population, data on the population of Moscow for the period 2019–2022 were used.

RESULTS: Over the period 2019–2022, a gradual trend towards an increase in the number of newly identified cases of cutaneous mastocytosis in children and adolescents in Moscow was revealed. Number of initial applications from children and adolescents (0–17 years old) for this period increased by 4.8 times. The share of cutaneous mastocytosis in the structure of skin diseases and congenital anomalies (malformations) of the skin increases every year. In 2019, for every 1,834 pediatric visits (age category 0–17 years) regarding skin diseases, there was 1 case of mastocytosis; in 2020 the ratio was 1,863:1; in 2021 ― 491:1; in 2022 ― 376:1. Since 2019, there has been an increase in the primary incidence of cutaneous mastocytosis from 3.63 cases per 100,000 child population to 16.61 cases per 100,000 child population in 2022.

CONCLUSION: The increase in incidence in the pediatric population and the share of cutaneous mastocytosis in the structure of skin diseases in recent years demonstrates the need to generate interest and attention of the medical community to this pathology.

About the authors

Elena I. Kasikhina

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology; Peoples' Friendship University of Russia

Author for correspondence.
Email: kasprof@bk.ru
ORCID iD: 0000-0002-0767-8821

MD, Cand. Sci. (Med.)

Russian Federation, Moscow; Moscow

Nikolay N. Potekaev

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology; The Russian National Research Medical University named after N.I. Pirogov

Email: klinderma@mail.ru
ORCID iD: 0000-0002-9578-5490

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow; Moscow

Maisa A. Ivanova

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Email: maisa961@mail.ru
ORCID iD: 0000-0002-7714-7970

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Olga V. Zhukova

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology; Peoples' Friendship University of Russia

Email: klinderma@inbox.ru
ORCID iD: 0000-0001-5723-6573

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow; Moscow

Olga L. Novozhilova

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Email: novozhilova.o@mail.ru
ORCID iD: 0000-0003-2897-3798
Russian Federation, Moscow

Maria N. Ostretsova

Peoples' Friendship University of Russia

Email: ostretsova-mn@rudn.ru
ORCID iD: 0000-0003-3386-1467

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Aizhan Okenaeva

Peoples' Friendship University of Russia

Email: okenaeva61@mail.ru
ORCID iD: 0000-0002-8094-0128
Russian Federation, Moscow

References

  1. Kaszuba A, Sławińska M, Żółkiewicz J, et al. Mastocytosis and Skin Cancer: The Current State of Knowledge. Int J Mol Sci. 2023;24(12):9840. doi: 10.3390/ijms24129840
  2. Valent P, Akin C, Sperr WR, et al. New insights into the pathogenesis of mastocytosis: Emerging concepts in diagnosis and therapy. Ann Rev Pathol. 2023;18:361–386. doi: 10.1146/annurev-pathmechdis-031521-042618
  3. Valent P, Hartmann K, Schwaab J, et al. Personalized management strategies in mast cell disorders: ECNM-AIM user's guide for daily clinical practice. J Allergy Clin Immunol. 2022;10(8):1999–2012.e6. doi: 10.1016/j.jaip.2022.03.007
  4. Hussain SH. Pediatric mastocytosis. Curr Opinion Pediatrics. 2020;32(4):531–538. doi: 10.1097/MOP.0000000000000922
  5. Wolff K, Komar M, Petzelbauer P. Clinical and histopathological aspects of cutaneous mastocytosis. Leukemia Res. 2001;25(7):519–528. doi: 10.1016/s0145-2126(01)00044-3
  6. Hartmann K, Henz BM. Mastocytosis: Recent advances in defining the disease. Br J Dermatol. 2001;144(4):682–695. doi: 10.1046/j.1365-2133.2001.04123.x
  7. Sagher F. Milestones in dermatology. XX. Mast cell disorders; the changing aspect of urticaria pigmentosa from a pure cutaneous to a systemic disease. Exc Med Dermatol Venereol. 1956;10(8):311–313.
  8. Degos R, Egos R, Delort J, et al. [Bullous mastocytosis; urticaria pigmentosa, diffuse mastocyte reticulosis, bullous eruptions. (French)]. Bull Soc Fr Dermatol Syphiligr. 1954;61(4):340–341.
  9. Méni C, Bruneau J, Georgin-Lavialle S, et al. Paediatric mastocytosis: A systematic review of 1747 cases. Br J Dermatol. 2015;172(3):642–651. doi: 10.1111/bjd.13567
  10. Cohen SS, Skovbo S, Vestergaard H, et al. Epidemiology of systemic mastocytosis in Denmark. Br J Dermatol. 2014;166(4):521–528. doi: 10.1111/bjh.12916
  11. Azaña JM, Torrelo A, Matito A. Update on mastocytosis (Part 1): Pathophysiology, clinical features, and diagnosis. Actas Dermosifiliogr. 2016;107(1):5–14. doi: 10.1016/j.ad.2015.09.007
  12. Lange M, Nedoszytko B, Górska A, et al. Mastocytosis in children and adults: Clinical disease heterogeneity. Archives of Medical Science. 2012;8(3):533–541. doi: 10.5114/aoms.2012.29409
  13. Brockow K. Epidemiology, prognosis, and risk factors in mastocytosis. Immunol Allergy Clin North Am. 2014;34(2):283–295. doi: 10.1016/j.iac.2014.01.003
  14. Tüysüz G, Özdemir N, Apak H, et al. Childhood mastocytosis: Results of a single center. Turkish Arch Ped. 2015;50(2):108–113. doi: 10.5152/tpa.2015.2332
  15. Lange M, Niedoszytko M, Renke J, et al. Clinical aspects of paediatric mastocytosis: A review of 101 cases. J Eur Acad Dermatol Venereol. 2013;27(1):97–102. doi: 10.1111/j.1468-3083.2011.04365.x
  16. Kiszewski АЕ, Durán-Mckinster С, Orozco-Covarrubias L, et al. Cutaneous mastocytosis in children: A clinical analysis of 71 cases. J Eur Acad Dermatol Venereol. 2004;18(3):285–290. doi: 10.1111/j.1468-3083.2004.00830.x
  17. Güneş Bilgili S, Karadağ AS, Takci Z, et al. Comparison of cutaneous mastocytosis with onset in children and adults. Turkish J Med Sci. 2014;44(3):504–510. doi: 10.3906/sag-1303-36
  18. Klaiber N, Kumar S, Irani AM. Mastocytosis in children. Curr Allergy Asthma ReP. 2017;17(11):80. doi: 10.1007/s11882-017-0748-4
  19. Valent P, Oude Elberink JN, Gorska A, et al.; Study Group of the European Competence Network on Mastocytosis (ECNM). The Data Registry of the European Competence Network on Mastocytosis (ECNM): Set Up, Projects, and Perspectives. J Allergy Clin Immunol. 2019;7(1):81–87. doi: 10.1016/j.jaip.2018.09.024
  20. Vakirlis E, Theodosiou G, Apalla Z, et al. A retrospective epidemiological study of skin diseases among pediatric population attending a tertiary dermatology referral center in Northern Greece. Clin Cosmet Investig Dermatol. 2017;10:99–104. doi: 10.2147/CCID.S130126
  21. Criscuolo M, Fianchi L, Maraglino AM, Pagano L. Mastocytosis: One word for different diseases. Oncol Ther. 2018;6(2):129–140. doi: 10.1007/s40487-018-0086-2

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Pharmarus Print Media

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).