Development of cofactor-dependent anaphylaxis in a patient with cross-reactive food allergy
- Authors: Smolnikov E.V.1,2,3, Litovkina A.O.1,2, Byazrova M.G.1,2
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Affiliations:
- Peoples' Friendship University of Russia
- National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
- National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
- Issue: Vol 20, No 4 (2023)
- Pages: 544-548
- Section: Case reports
- URL: https://journals.rcsi.science/raj/article/view/253271
- DOI: https://doi.org/10.36691/RJA16898
- ID: 253271
Cite item
Abstract
Anaphylaxis is a severe life-threatening systemic IgE-dependent hypersensitivity reaction that develops rapidly and can be fatal. As a rule, an anaphylactic reaction develops in response to food, insect stings, and medicine drugs. Sometimes, cofactors can modulate anaphylaxis and significantly reduce the required allergen dose for the development of an anaphylactic reaction. In such cases, anaphylaxis is considered cofactor-dependent. Alcohol consumption is a leading factor in cofactor-dependent anaphylaxis. This article presents a clinical case of cofactor-dependent anaphylaxis. Skin testing with extracts of inhalation allergens and molecular allergy diagnostics using the ImmunoCAP ISAC allergochip (112 allergy components) performed at the Institute of Immunology (Moscow) showed positive results with pollen allergens of deciduous trees and meadow grasses and an increase in the level of specific immunoglobulin E (sIgE) to the main inhalation allergens — birch, hazel, alder, Timothy, pigweed, and wormwood pollen, and to cross-reacting components of allergens from the PR-10 protein group, such as soya bean, kiwi, apple, peach, celery, peanut, and hazelnut. Based on the results of molecular allergy diagnostics, a personalized elimination diet was prepared and recommendations were made to the patient.
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##article.viewOnOriginalSite##About the authors
Eugeniy V. Smolnikov
Peoples' Friendship University of Russia; National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: qwertil2010@yandex.ru
ORCID iD: 0000-0003-1302-4178
SPIN-code: 4874-8100
Russian Federation, Moscow; Moscow; Moscow
Alla O. Litovkina
Peoples' Friendship University of Russia; National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
Email: dr.litovkina@gmail.com
ORCID iD: 0000-0002-5021-9276
SPIN-code: 2337-7930
Russian Federation, Moscow; Moscow
Maria G. Byazrova
Peoples' Friendship University of Russia; National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
Author for correspondence.
Email: mbyazrova@list.ru
ORCID iD: 0000-0002-9858-7596
SPIN-code: 4317-9042
Russian Federation, Moscow; Moscow
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