Food allergy: Trends in the development of allergen-specific immunotherapy technologies
- Authors: Kutas U.V.1, Prokopyeva V.D.1, Fedotova M.M.1, Fedorova O.S.1
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Affiliations:
- Siberian State Medical University
- Issue: Vol 20, No 3 (2023)
- Pages: 321-331
- Section: Systematic reviews
- URL: https://journals.rcsi.science/raj/article/view/251325
- DOI: https://doi.org/10.36691/RJA13055
- ID: 251325
Cite item
Abstract
BACKGROUND: Food allergy is an urgent problem for public health around the world. One of the most promising methods of food allergy treatment is allergen-specific immunotherapy.
AIM: to analyze the results of clinical studies on the effectiveness and safety of modern allergen-specific immunotherapy technologies in the treatment of food allergies published over the past three years.
MATERIALS AND METHODS: A search and analysis of scientific publications was carried out using resources cataloging biomedical scientific literature: PubMed and eLibrary. The review includes original studies published between January 1, 2020 and December 31, 2022.
RESULTS: The review made it possible to systematize the data accumulated over the past three years, reflecting the main trends in allergen-specific immunotherapy of food allergy. The analysis of studies showed modern approaches to oral and epicutaneous immunotherapy and affected the efficacy and safety of these types of treatment. In food allergy cohorts, the allergen-specific immunotherapy approach of oral and epicutaneous allergen-specific immunotherapy has been shown to be highly effective in achieving tolerance and desensitization to the food trigger it was revealed that epicutaneous allergen-specific immunotherapy is characterized by a high level of adherence of patients to treatment.
CONCLUSION: It is necessary to continue conducting large-scale clinical studies on modern methods of allergen-specific immunotherapy in patients with food allergies to form standardized therapy protocols.
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##article.viewOnOriginalSite##About the authors
Ulyana V. Kutas
Siberian State Medical University
Author for correspondence.
Email: uliaka007@gmail.com
ORCID iD: 0000-0003-3495-0832
SPIN-code: 3201-5750
Russian Federation, Tomsk
Valeria D. Prokopyeva
Siberian State Medical University
Email: valeriya.d.prokopyeva@gmail.com
ORCID iD: 0000-0002-0728-5825
SPIN-code: 1072-4300
Russian Federation, Tomsk
Marina M. Fedotova
Siberian State Medical University
Email: fedotova.letter@gmail.com
ORCID iD: 0000-0001-7655-7911
SPIN-code: 1488-8189
MD, Cand Sci (Med.), Assistant Professor
Russian Federation, TomskOlga S. Fedorova
Siberian State Medical University
Email: fedorova.os@ssmu.ru
ORCID iD: 0000-0002-7130-9609
SPIN-code: 5285-4593
MD, Dr. Sci. (Med.), Professor
Russian Federation, TomskReferences
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