Tropomyosins of the helminthes: Sensitization and association with allergic diseases

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Abstract

The increase in the prevalence of allergic diseases has been a driver of the development of new technologies. Over the past two decades, significant progress in biochemistry and molecular allergology has contributed to the study of the structure of allergens and development of component-resolved diagnostics. Specifically, clinically significant families of allergens have been identified, including tropomyosin, which can cause various cross-IgE-mediated reactions. One of the risk factors for sensitization development is helminthiasis, which is common in different regions and population of endemic areas. The global prevalence of helminthiasis remains high. Approximately 1.5 billion people worldwide have chronic infections with at least one helminth.

This review aimed to analyze current studies determining the relationship between helminth infections and the development of sensitization to helminth tropomyosin and clinical course of allergic diseases.

The analysis of scientific publications described the relationship between helminth tropomyosin and the development of allergic diseases and sensitization in patients with parasitic infection. The PubMed database was used for the review. The review included original articles published between January 1, 2000, and December 31, 2021.

About the authors

Vladislava A. Rovitskaya

Siberian State Medical University

Author for correspondence.
Email: rovitskayaVA@mail.ru
ORCID iD: 0000-0001-5084-2220
SPIN-code: 1123-3796
Russian Federation, Tomsk

Olga S. Fedorova

Siberian State Medical University

Email: fedorova.os@ssmu.ru
ORCID iD: 0000-0002-7130-9609
SPIN-code: 5285-4593

MD, Dr. Sci. (Med.), Professor

Russian Federation, Tomsk

Elena M. Kamaltynova

Siberian State Medical University

Email: eleant21@yandex.ru
ORCID iD: 0000-0002-2234-5355
SPIN-code: 9835-1321

MD, Dr. Sci. (Med.), Professor

Russian Federation, Tomsk

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Copyright (c) 2023 Rovitskaya V.A., Fedorova O.S., Kamaltynova E.M.

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