CELL PENETRATING PEPTIDE COMPLEXED WITH SIRNA TARGETED TO IL-4 DECREASE AIRWAY INFLAMMATION AND AIRWAY HYPER RESPONSIVENESS IN A MOUSE MODEL OF ALLERGIC ASTHMA
- Authors: Shilovskiy IP1, Sundukova MS1, Gaisina AR1, Zaretskaya VA1, Kamyshnikov OY1, Khaitov MR1
-
Affiliations:
- National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
- Issue: Vol 14, No 1S (2017)
- Pages: 204-205
- Section: Articles
- URL: https://journals.rcsi.science/raj/article/view/121908
- DOI: https://doi.org/10.36691/RJA274
- ID: 121908
Cite item
Full Text
Full Text
##article.viewOnOriginalSite##About the authors
I P Shilovskiy
National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
M S Sundukova
National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
A R Gaisina
National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
V A Zaretskaya
National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
O Y Kamyshnikov
National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
M R Khaitov
National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
References
- Holgate S.T. The sentinel role of the airway epithelium in asthma pathogenesis. // Immunol. Rev. 2011. Vol. 242, № 1. P. 205-219.
- Grünig G. et al. Requirement for IL-13 independently of IL-4 in experimental asthma. // Science. 1998. Vol. 282, № 5397. P. 2261-2263.
- Perkins C., Wills-Karp M., Finkelman F.D. IL-4 induces IL-13-independent allergic airway inflammation. // J. Allergy Clin. Immunol. 2006. Vol. 118, № 2. P. 410419.
- Maes T., Joos G.F., Brusselle G.G. Targeting interleukin-4 in asthma: lost in translation? // Am. J. Respir. Cell Mol. Biol. 2012. Vol. 47, № 3. P. 261-270.
- Chatila T.A. Interleukin-4 receptor signaling pathways in asthma pathogenesis // Trends in Molecular Medicine. 2004. Vol. 10, № 10. P. 493-499.
- Шиловский И.П. и др. Интерференция РНК -новый подход в терапии аллергической бронхиальной астмы // Экспериментальная и клиническая фармакология. 2016. Vol. 79, № 4. P. 35-44.
- Koloskova O.O. et al. Synthesis and evaluation of novel lipopeptide as a vehicle for efficient gene delivery and gene silencing // Eur J Pharm Biopharm. 2016. Vol. 102. P. 159-167.
- Шиловский И.П. и др., Разработка модели РНКи-опосредованной супрессии гена интерлейкина-4 in vitro // Физиология и патология иммунной системы. 2011. Vol. 15, № 6. P. 3-12.
- Шиловский И.П. и др., Синтетические siRNA эффективно подавляют экспрессию провоспалительного цитокина интерлейкина-4 мыши in vitro // Иммунология. 2012. Vol. 2. P. 66-70.
- Шиловский И.П. и др., Разработка безадъювантной модели хронической бронхиальной астмы у мышей // Российский иммунологический журнал. 2014. Vol. 3, № 17. P. 638-641.
- Shilovskiy I.P. et al. Adjuvant and adjuvant-free protocols produce similar phenotypes of allergic asthma in mice // Curr. Trends Immunol. 2015. Vol. 16. P. 79-91.
