Clinical characteristics of chronic spontaneous urticaria in patients with Common variable immune deficiency and hypogammaglobulinemia
- Authors: Latysheva T.V.1, Latysheva E.A.1, Danilycheva I.V.1, Frolov E.A.1
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Affiliations:
- National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
- Issue: Vol 18, No 4 (2021)
- Pages: 140-148
- Section: Case reports
- URL: https://journals.rcsi.science/raj/article/view/121708
- DOI: https://doi.org/10.36691/RJA1488
- ID: 121708
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Abstract
Chronic spontaneous urticaria is a prevalent disease that is associated with various autoimmune, infectious (viral, bacterial, parasitic), and non-infectious inflammatory pathologies, and could occur in the symptom complex of other diseases, such as primary immunodeficiencies. Nowadays, data on the features of chronic spontaneous urticaria in patients with primary immunodeficiencies are accumulating. Common variable immune deficiency takes a special place in clinical practice among primary immunodeficiencies with impaired antibody synthesis and is associated with late-onset in adulthood, as well as the heterogeneity of its clinical manifestations, such as infectious and non-infectious complications, which can serve as a background for chronic urticaria development. Intravenous Immunoglobulin (IVIg) replacement therapy is the mainstay of treatment and prevention of infectious complications in these patients; however, immunomodulatory and anti-inflammatory effects can occur in high doses.
Herein, presented two clinical cases of patients with common variable immune deficiency and one with hypogammaglobulinemia who suffer from chronic spontaneous urticaria. The peculiarities of IVIg replacement therapy at urticaria were noted in these patients. The discussion presents the review of world literature and proposes key features for further investigations.
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##article.viewOnOriginalSite##About the authors
Tatiana V. Latysheva
National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
Email: tvlat@mail.ru
ORCID iD: 0000-0003-1508-0640
SPIN-code: 8929-7644
MD, Dr. Sci. (Med.), Professor
Russian Federation, 24 Kashirskoe shosse, Moscow, 115522Elena A. Latysheva
National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
Email: ealat@mail.ru
ORCID iD: 0000-0002-1606-205X
SPIN-code: 2063-7973
MD, Dr. Sci. (Med.)
Russian Federation, 24 Kashirskoe shosse, Moscow, 115522Inna V. Danilycheva
National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
Email: ivdanilycheva@mail.ru
ORCID iD: 0000-0002-8279-2173
SPIN-code: 4547-3948
MD, Cand. Sci. (Med.)
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Evgeny A. Frolov
National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia
Author for correspondence.
Email: frolovevgeny@rambler.ru
ORCID iD: 0000-0002-0800-5960
SPIN-code: 5963-4062
MD
Russian Federation, 24 Kashirskoe shosse, Moscow, 115522References
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