Chronic urticaria in theory and practice. Experience of UCARE-centers for clinicians
- Authors: Ilyina N.I.1, Danilycheva I.V.1, Dorofeeva I.V.1, Elisyutina O.G.1, Kurbacheva O.M.1, Latysheva E.A.1, Litvin L.S.2, Manto I.A.1, Nazarova E.V.1, Pavlova K.S.1, Primak A.S.1, Fedenko E.S.1, Schubelko R.V.1
-
Affiliations:
- National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
- Novartis Pharma LLC
- Issue: Vol 18, No 1 (2021)
- Pages: 79-96
- Section: Letters to the editor
- URL: https://journals.rcsi.science/raj/article/view/121664
- DOI: https://doi.org/10.36691/RJA1425
- ID: 121664
Cite item
Abstract
Chronic urticaria (CU) is an urgent medical and social problem. The instruments of everyday clinical practice are international and domestic guidelines which briefly reflect modern ideas about various aspects of CU. Recently, a new opportunity has emerged to expand theoretical and practical experience in the management of patients with CU, to carry out educational activities to disseminate modern knowledge about urticaria, to conduct research in the field of studying the pathogenesis, treatment, and prevention of exacerbations of the disease. This opportunity is realized through the centers of excellence for working with such patients (GA2LEN UCARE centers). One of the five Russian centers, have prepared and conducted an online training program “Chronic urticaria: scientific and medical achievements and practical aspects of patient management” at the Federal State Budgetary Institution State Research Center “Institute of Immunology” FMBA of Russia. The event was held by the employees of the Federal State Budgetary Institution State Research Center “Institute of Immunology” of the FMBA of Russia on November, 2020.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Natalia I. Ilyina
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Author for correspondence.
Email: instimmun@yandex.ru
ORCID iD: 0000-0002-3556-969X
SPIN-code: 6715-5650
MD, Dr. Sci. (Med.), Professor
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Inna V. Danilycheva
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: ivdanilycheva@mail.ru
ORCID iD: 0000-0002-8279-2173
SPIN-code: 4547-3948
MD, Cand. Sci. (Med.)
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Irina V. Dorofeeva
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: idorofeeva1@gmail.com
ORCID iD: 0000-0002-4423-1797
MD
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Olga G. Elisyutina
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: el-olga@yandex.ru
ORCID iD: 0000-0002-4609-2591
SPIN-code: 9567-1894
MD, Dr. Sci. (Med.)
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Oksana M. Kurbacheva
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: kurbacheva@gmail.com
ORCID iD: 0000-0003-3250-0694
SPIN-code: 5698-6436
MD, Dr. Sci. (Med.), Professor
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Elena A. Latysheva
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: ealat@mail.ru
ORCID iD: 0000-0002-1606-205X
SPIN-code: 2063-7973
MD, Dr. Sci. (Med.)
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Loliana S. Litvin
Novartis Pharma LLC
Email: loliana.litvin@novartis.com
ORCID iD: 0000-0002-2229-1078
SPIN-code: 6105-1370
MD, Cand. Sci. (Med.)
Russian Federation, MoscowIrina A. Manto
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: irina.manto@yandex.ru
ORCID iD: 0000-0001-6432-394X
SPIN-code: 7944-5159
MD, Cand. Sci. (Med.)
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Evgeniya V. Nazarova
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: evallergo@yandex.ru
ORCID iD: 0000-0003-0380-6205
SPIN-code: 4788-7407
MD, Cand. Sci. (Med.)
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Ksenia S. Pavlova
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: ksenimedical@gmail.com
ORCID iD: 0000-0002-4164-4094
SPIN-code: 7593-0838
MD, Cand. Sci. (Med.)
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Anastasia S. Primak
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: soulcreek.94@mail.ru
ORCID iD: 0000-0003-1309-5101
MD
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Elena S. Fedenko
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: efedks@gmail.com
ORCID iD: 0000-0003-3358-5087
SPIN-code: 5012-7242
MD, Dr. Sci. (Med.), Professor
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Rosalia V. Schubelko
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: spapharia@gmail.com
ORCID iD: 0000-0001-6993-9831
SPIN-code: 4553-3234
MD, Cand. Sci. (Med.)
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522References
- Fricke J, Ávila G, Keller T, et al. Prevalence of chronic urticaria in children and adults across the globe: Systematic review with meta-analysis. Allergy. 2020;75(2):423–432. doi: 10.1111/all.14037
- Gonçalo M, Gimenéz-Arnau A, Al-Ahmad M, et al. The global burden of chronic urticaria for the patient and society. Br J Dermatol. 2021;184(2):226–236. doi: 10.1111/bjd.19561
- Danilycheva IV, Ilina NI, Luss LV, et al. Russian Federal clinical recomendations on chronic urticaria diagnostics and treatment. Russian Journal of Allergy. 2016;(1):38–46. (In Russ).
- Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393–1414. doi: 10.1111/all.13397
- Maurer M, Metz M, Bindslev-Jensen C, et al. Definition, aims, and implementation of GA(2) LEN Urticaria Centers of Reference and Excellence. Allergy. 2016;71(8):1210–1218. doi: 10.1111/all.12901
- Kocatürk E. Treatment patterns and outcomes in patients with chronic urticaria during pregnancy: Results of the PREG-CU study, a UCARE project. Oral presentation. GA²LEN GLOBAL URTICARIA FORUM 2020. Available from: www.globalurticariaforum.org
- Weller K, Giménez-Arnau A, Grattan C, et al. CURE Investigators. The Chronic Urticaria Registry: rationale, methods and initial implementation. J Eur Acad Dermatol Venereol. 2021;35(3):721–729. doi: 10.1111/jdv.16947
- Allergology and clinical immunology. Clinical recommendations. Ed. by R.M. Khaitov, N.I. Ilyina. Moscow: GEOTAR-Media; 2019. 352 p. (Series “Clinical recommendations”). (In Russ).
- Antia C, Baquerizo K, Korman A, et al. Urticaria: A comprehensive review: Epidemiology, diagnosis, and work-up. J Am Acad Dermatol. 2018;79(4):599–614. doi: 10.1016/j.jaad.2018.01.020
- Bernstein JA, Lang DM, Khan DA, et al. The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol. 2014;133(5):1270–1277. doi: 10.1016/j.jaci.2014.02.036
- Maurer M, Weller K, Bindslev-Jensen C, et al. Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report. Allergy. 2011;66(3):317–330. doi: 10.1111/j.1398-9995.2010.02496.x
- Maurer M, Eyerich K, Eyerich S, et al. Urticaria: collegium internationale allergologicum (CIA) update 2020. Int Arch Allergy Immunol. 2020;181(5):321–333. doi: 10.1159/000507218
- Schmetzer O, Lakin E, Topal FA, et al. IL-24 is a common and specific autoantigen of IgE in patients with chronic spontaneous urticaria. J Allergy Clin Immunol. 2018;142(3):876–882. doi: 10.1016/j.jaci.2017.10.035
- Altrichter S, Peter HJ, Pisarevskaja D, et al. IgE mediated autoallergy against thyroid peroxidase--a novel pathomechanism of chronic spontaneous urticaria? PLoS One. 2011;6(4):e14794. doi: 10.1371/journal.pone.0014794
- Hatada Y, Kashiwakura J, Hayama K, et al. Significantly high levels of anti-dsDNA immunoglobulin E in sera and the ability of dsDNA to induce the degranulation of basophils from chronic urticaria patients. Int Arch Allergy Immunol. 2013;161(Suppl 2):154–158. doi: 10.1159/000350388
- Cugno M, Asero R, Ferrucci S, et al. Elevated IgE to tissue factor and thyroglobulin are abated by omalizumab in chronic spontaneous urticaria. Allergy. 2018;73(12):2408–2411. doi: 10.1111/all.13587
- Bracken SJ, Abraham S, MacLeod AS. Autoimmune theories of chronic spontaneous urticaria. Front Immunol. 2019;10:627. doi: 10.3389/fimmu.2019.00627
- Sánchez J, Sánchez A, Cardona R. Causal relationship between anti-TPO IgE and chronic urticaria by in vitro and in vivo tests. Allergy Asthma Immunol Res. 2019;11(1):29–42. doi: 10.4168/aair.2019.11.1.29
- Staubach P, Vonend A, Burow G, et al. Patients with chronic urticaria exhibit increased rates of sensitisation to Candida albicans, but not to common moulds. Mycoses. 2009;52(4):334–338. doi: 10.1111/j.1439-0507.2008.01601.x
- Altrichter S, Fok JS, Jiao Q, et al. Total IgE as a marker for chronic spontaneous urticaria. Allergy Asthma Immunol Res. 2021;13(2):206–218. doi: 10.4168/aair.2021.13.2.206
- Ferrer M, Kinét JP, Kaplan AP. Comparative studies of functional and binding assays for IgG anti-Fc(epsilon)RIalpha (alpha-subunit) in chronic urticaria. J Allergy Clin Immunol. 1998;101(5):672–676. doi: 10.1016/s0091-6749(98)70176-9
- Maurer M, Metz M, Brehler R, et al. Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence. J Allergy Clin Immunol. 2018;141(2):638–649. doi: 10.1016/j.jaci.2017.06.032
- Konstantinou GN, Asero R, Maurer M, et al. EAACI/GA(2)LEN task force consensus report: the autologous serum skin test in urticaria. Allergy. 2009;64(9):1256–1268. doi: 10.1111/j.1398-9995.2009.02132.x
- Kolkhir P, Borzova E, Grattan C, et al. Autoimmune comorbidity in chronic spontaneous urticaria: A systematic review. Autoimmun Rev. 2017;16(12):1196–1208. doi: 10.1016/j.autrev.2017.10.003
- Netchiporouk E, Sasseville D, Moreau L, et al. Evaluating comorbidities, natural history, and predictors of early resolution in a cohort of children with chronic urticaria. JAMA Dermatol. 2017;153(12):1236–1242. doi: 10.1001/jamadermatol.2017.3182
- Silpa-archa N, Kulthanan K, Pinkaew S. Physical urticaria: prevalence, type and natural course in a tropical country. J Eur Acad Dermatol Venereol. 2011;25(10):1194–1199. doi: 10.1111/j.1468-3083.2010.03951.x
- Maurer M, Abuzakouk M, Bérard F, et al. The burden of chronic spontaneous urticaria is substantial: Real-world evidence from ASSURE-CSU. Allergy. 2017;72(12):2005–2016. doi: 10.1111/all.13209
- Trevisonno J, Balram B, Netchiporouk E, Ben-Shoshan M. Physical urticaria: Review on classification, triggers and management with special focus on prevalence including a meta-analysis. Postgrad Med. 2015;127(6):565–570. doi: 10.1080/00325481.2015.1045817
- Weller K, Groffik A, Church MK, et al. Development and validation of the Urticaria Control Test: a patient-reported outcome instrument for assessing urticaria control. J Allergy Clin Immunol. 2014. Vol. 133, N 5. P. 1365–1372.
- Folci M, Heffler E, Canonica GW, et al. Cutting edge: biomarkers for chronic spontaneous urticaria. J Immunol Res. 2018;2018:5615109. doi: 10.1155/2018/5615109
- Guillén-Aguinaga S, Jáuregui Presa I, Aguinaga-Ontoso E, et al. Updosing nonsedating antihistamines in patients with chronic spontaneous urticaria: a systematic review and meta-analysis. Br J Dermatol. 2016;175(6):1153–1165. doi: 10.1111/bjd.14768
- Conlon NP, Edgar JD. Adherence to best practice guidelines in chronic spontaneous urticaria (CSU) improves patient outcome. Eur J Dermatol. 2014;24(3):385–386. doi: 10.1684/ejd.2014.2323
- Kaplan AP, Giménez-Arnau AM, Saini SS. Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria. Allergy. 2017;72(4):519–533. doi: 10.1111/all.13083
- MacGlashan DW, Bochner BS, Adelman DC, et al. Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol. 1997;158(3):1438–1445
- Beck LA, Marcotte GV, MacGlashan D, et al. Omalizumab-induced reductions in mast cell Fce psilon RI expression and function. J Allergy Clin Immunol. 2004;114(3):527–530. doi: 10.1016/j.jaci.2004.06.032
- MacGlashan DJ, Xia HZ, Schwartz LB, Gong J. IgE-regulated loss, not IgE-regulated synthesis, controls expression of FcepsilonRI in human basophils. J Leukoc Biol. 2001;70(2):207–218
- Saini SS, Bindslev-Jensen C, Maurer M, et al. Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on H1 antihistamines: a randomized, placebo-controlled study. J Invest Dermatol. 2015;135(1):67–75. doi: 10.1038/jid.2014.306
- Gericke J, Metz M, Ohanyan T, et al. Serum autoreactivity predicts time to response to omalizumab therapy in chronic spontaneous urticaria. J Allergy Clin Immunol. 2017;139(3):1059–1061.e1. doi: 10.1016/j.jaci.2016.07.047
- Eggel A, Baravalle G, Hobi G, et al Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells. J Allergy Clin Immunol. 2014;133(6):1709–1719.e8. doi: 10.1016/j.jaci.2014.02.005
- Serrano-Candelas E, Martinez-Aranguren R, Valero A, et al. Comparable actions of omalizumab on mast cells and basophils. Clin Exp Allergy. 2016;46(1):92–102. doi: 10.1111/cea.12668
- Jacques P, Lavoie A, Bédard PM, et al. Chronic idiopathic urticaria: profiles of skin mast cell histamine release during active disease and remission. J Allergy Clin Immunol. 1992;89(6):1139–1143. doi: 10.1016/0091-6749(92)90297-f
- Bédard PM, Brunet C, Pelletier G, Hébert J. Increased compound 48/80 induced local histamine release from nonlesional skin of patients with chronic urticaria. J Allergy Clin Immunol. 1986;78(6):1121–1125. doi: 10.1016/0091-6749(86)90260-5
- Noga O, Hanf G, Brachmann I, et al. Effect of omalizumab treatment on peripheral eosinophil and T-lymphocyte function in patients with allergic asthma. J Allergy Clin Immunol. 2006;117(6):1493–1499. doi: 10.1016/j.jaci.2006.02.028
- Maurer M, Altrichter S, Bieber T, et al. Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase. J Allergy Clin Immunol. 2011;128(1):202–209.e5. doi: 10.1016/j.jaci.2011.04.038
- Saini S, Rosen KE, Hsieh HJ, et al. A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria. J Allergy Clin Immunol. 2011;128(3):567–573.e1. doi: 10.1016/j.jaci.2011.06.010
- Maurer M, Rosén K, Hsieh HJ, et al. Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. N Engl J Med. 2013;368(10):924–935. doi: 10.1056/NEJMoa1215372
- Kaplan A, Ledford D, Ashby M, et al. Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy. J Allergy Clin Immunol. 2013;132(1):101–109. doi: 10.1016/j.jaci.2013.05.013
- Zhao ZT, Ji CM, Yu WJ, et al. Omalizumab for the treatment of chronic spontaneous urticaria: A meta-analysis of randomized clinical trials. J Allergy Clin Immunol. 2016;137(6):1742–1750.e4. doi: 10.1016/j.jaci.2015.12.1342
- Tharp MD, Bernstein JA, Kavati A, et al. Benefits and harms of omalizumab treatment in adolescent and adult patients with chronic idiopathic (Spontaneous) urticaria: a meta-analysis of “Real-world” evidence. JAMA Dermatol. 2019;155(1):29–38. doi: 10.1001/jamadermatol.2018.3447
- Asero R, Canonica GW, Cristaudo A, et al. Critical appraisal of the unmet needs in the treatment of chronic spontaneous urticaria with omalizumab: an Italian perspective. Curr Opin Allergy Clin Immunol. 201717(6):453–459. doi: 10.1097/ACI.0000000000000404.
- Casale TB, Murphy TR, Holden M, et al. Impact of omalizumab on patient-reported outcomes in chronic idiopathic urticaria: Results from a randomized study (XTEND-CIU). J Allergy Clin Immunol Pract. 2019;7(7):2487–2490.e1. doi: 10.1016/j.jaip.2019.04.020
- Vadasz Z, Tal Y, Rotem M, et al. Israeli Forum for investigating and treating Chronic Spontaneous Urticaria (CSU). Omalizumab for severe chronic spontaneous urticaria: Real-life experiences of 280 patients. J Allergy Clin Immunol Pract. 2017;5(6):1743–1745. doi: 10.1016/j.jaip.2017.08.035
- Staubach P, Metz M, Chapman-Rothe N, et al. Effect of omalizumab on angioedema in H1-antihistamine-resistant chronic spontaneous urticaria patients: results from X-ACT, a randomized controlled trial. Allergy. 2016;71(8):1135–1144. doi: 10.1111/all.12870
- Metz M, Vadasz Z, Kocatürk E, Giménez-Arnau AM. Omalizumab updosing in chronic spontaneous urticaria: an overview of real-world evidence. Clin Rev Allergy Immunol. 2020;59(1):38–45. doi: 10.1007/s12016-020-08794-6
- Türk M, Carneiro-Leão L, Kolkhir P, et al. How to treat patients with chronic spontaneous urticaria with omalizumab: questions and answers. J Allergy Clin Immunol Pract. 2020;8(1):113–124. doi: 10.1016/j.jaip.2019.07.021
- Kulthanan K, Tuchinda P, Likitwattananurak C, et al. Does omalizumab modify a course of recalcitrant chronic spontaneous urticaria? A retrospective study in Asian patients. J Dermatol. 2018;45(1):17–23. doi: 10.1111/1346-8138.14081
- Maurer M, Giménez-Arnau A, Ensina LF, et al. Chronic urticaria treatment patterns and changes in quality of life: AWARE study 2-year results. World Allergy Organ J. 2020;13(9):100460. doi: 10.1016/j.waojou.2020.100460
- Kocatürk E, Maurer M, Metz M, Grattan C. Looking forward to new targeted treatments for chronic spontaneous urticaria. Clin Transl Allergy. 2017;7:1. doi: 10.1186/s13601-016-0139-2
- Arm JP, Bottoli I, Skerjanec A, et al. Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects. Clin Exp Allergy. 2014;44(11):1371–1385. doi: 10.1111/cea.12400
- Gasser P, Tarchevskaya SS, Guntern P, et al. The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nat Commun. 2020;11(1):165. doi: 10.1038/s41467-019-13815-w
- Angst D, Gessier F, Janser P, et al. Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase. J Med Chem. 2020;63(10):5102–5118. doi: 10.1021/acs.jmedchem.9b01916
- Nutku E, Aizawa H, Hudson SA, Bochner BS. Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. Blood. 2003;101(12):5014–5020. doi: 10.1182/blood-2002-10-3058
- Yokoi H, Choi OH, Hubbard W, et al. Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. J Allergy Clin Immunol. 2008;121(2):499–505.e1. doi: 10.1016/j.jaci.2007.10.004