Indicators of activin A in patients with external genital endometriosis. Materials of 15th International Interdisciplinary Congress on Allergology and Immunology (May 22-24, 2019, Moscow)


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Abstract

Actuality. External genital endometriosis (EGE), leading to functional and structural changes in the reproductive system and infertility, takes the 3rd place in the structure of gynecological pathology. Objective. To determine the local and systemic level of activin A in patients with external genital endometriosis. Materials and methods. The study included 71 patients with EGE, who were divided into two groups: 1 group - patients with I-II stages (n=31); 2 - patients with III-IV stages (n=40). The control group included 24 patients without EGE. The determination of the level of activin A in the serum and peritoneal fluid was performed by enzyme immunoassay using DSL test systems (USA). Results. In the blood serum the level of activin A exceeded in patients of both studied groups compared the control group, but the most evident changes were observed in patients with stage III-IV of EGE. In the study of peritoneal fluid an increase in activin A was found only in patients in the 2nd group. Conclusion. An increase of serum and peritoneal fluid activin A level was associated with the risk of developing of EGE in patients of reproductive age.

About the authors

M A Levkovich

Rostov State Medical University of the Ministry of Health of Russia, Research Institute of Obstetrics and Pediatrics

Email: xlma@mail.ru
доктор медицинских наук, доцент, ведущий научный сотрудник отдела медико-биологических проблем в акушерстве, гинекологии и педиатрии

N V Ermolova

Rostov State Medical University of the Ministry of Health of Russia, Research Institute of Obstetrics and Pediatrics

доктор медицинских наук, доцент, начальник акушерско-гинекологического отдела

I I Krukier

Rostov State Medical University of the Ministry of Health of Russia, Research Institute of Obstetrics and Pediatrics

доктор биологических наук, ведущий научный сотрудник отдела медико-биологических проблем в акушерстве, гинекологии и педиатрии

T G Avanesova

Rostov State Medical University of the Ministry of Health of Russia, Research Institute of Obstetrics and Pediatrics

аспирант акушерско-гинекологического отдела научно-исследовательского института акушерства и педиатрии

A A Nikashina

Rostov State Medical University of the Ministry of Health of Russia, Research Institute of Obstetrics and Pediatrics

кандидат биологических наук, научный сотрудник отдела медико-биологических проблем в акушерстве, гинекологии и педиатрии

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