Histafen antihistaminic and sedative effects in patients with chronic recurrent urticaria
- Authors: Luss LV1, Tuzlukova EB1, Grebenchenko EI1
-
Affiliations:
- Institute of Immunology
- Issue: Vol 7, No 3 (2010)
- Pages: 68-73
- Section: Articles
- URL: https://journals.rcsi.science/raj/article/view/121494
- DOI: https://doi.org/10.36691/RJA909
- ID: 121494
Cite item
Abstract
The purposes of the study. The primary purpose was to show antihistaminic efficiency of Histafen in a daily doze of 150 mg per os within 14 days at patients with chronic urticaria (ChU) on an example of suppression of the skin reaction caused by histamin. The secondary purposes: To estimate a condition of microcirculation in the skin of patients with ChU during Histafen treatment and to confirm safety and absence of sedative effect of Histafen. Materials and methods of study. There were 20 adult patients (men and women) in the age from 18 to 55, with exacerbation of ChU included in the study; 20 healthy persons - as a control group. We made clinic and laboratory examination to all patients, including skin pricktitration with histamin, research of local microcirculation in a skin. Sedative effect estimated on the change of stability of attention by means of B. Burdon's proof test and volume of attention by Shulte tables.
Results. Histafen suppression of the skin urticaria and hyperemia which was caused by histamine in ChU patients was established: for 50% and 40% respectively. However these results are statistically doubtful - p=0,27 and p=0,18 respectively. The revealed changes of local microcirculation in the skin can testify to normalization of basal blood-groove parameters in skin of patients with ChU. Absence of sedative effect during of Histafen treatment was established: absence of statistically approved changes in parameters of volume of attention (p=0,6) and authentic improvement of stability of attention after the treatment (p=0,01) was noted. The conclusion. The study demonstrated high antihistaminic activity of Histafen, its safety and absence of sedative effect in patients with ChU.
Results. Histafen suppression of the skin urticaria and hyperemia which was caused by histamine in ChU patients was established: for 50% and 40% respectively. However these results are statistically doubtful - p=0,27 and p=0,18 respectively. The revealed changes of local microcirculation in the skin can testify to normalization of basal blood-groove parameters in skin of patients with ChU. Absence of sedative effect during of Histafen treatment was established: absence of statistically approved changes in parameters of volume of attention (p=0,6) and authentic improvement of stability of attention after the treatment (p=0,01) was noted. The conclusion. The study demonstrated high antihistaminic activity of Histafen, its safety and absence of sedative effect in patients with ChU.
About the authors
L V Luss
Institute of Immunology
Email: lusslv@yandex.ru
Institute of Immunology
E B Tuzlukova
Institute of ImmunologyInstitute of Immunology
E I Grebenchenko
Institute of ImmunologyInstitute of Immunology
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