Role of skin microbiome in epidermal barrier dysfunction and development of atopic dermatitis in high risk infants
- Authors: Migacheva NB1
-
Affiliations:
- Samara State Medical University
- Issue: Vol 16, No 1 (2019)
- Pages: 59-64
- Section: Articles
- URL: https://journals.rcsi.science/raj/article/view/120479
- DOI: https://doi.org/10.36691/RJA26
- ID: 120479
Cite item
Full Text
Abstract
Background. Colonization of skin with S. aureus in atopic dermatitis (AD) patients is a widespread phenomenon and a factor complicating the course of the disease. At present, it is not quite clear the role of S. aureus in the development of AD in children at risk. The aim of our study was to discribe the skin microbiome composition in young children at risk, as well as to investigate the role of S. aureus in skin barrier dysfunction and the development of AD. Material and methods. 12months follow-up study of 37 infants at risk has been performed. It included a general clinical examination, a microbiological investigation of skin microbiome (at 1 and 6 months), and investigation of epidermal barrier function by determining the transepidermal water loss (TEWL) at 1, 3, 6 and 12 months. Realization of AD during the observation period was considered as main outcome. Results. The prevalence of S. aureus colonization of infants aged 1 month was 45.9%, at the age of 6 months - 29.7%. Correlation analysis revealed an association between the skin colonization with S. aureus and a decrease of TEWL (p = 0.004), as well as the cumulative incidence of AD (p <0.001). Conclusion. The detection of S. aureus as a part of skin microbiocenosis in AD infants at risk is associated with dysfunction of the epidermal barrier and is a significant risk factor for the AD development.
Full Text
##article.viewOnOriginalSite##References
- Kong HH, Segre JA. Skin microbiome: looking back to move forward. J. Invest Dermatol. 2012;132(3):933-939. doi: 10.1038/jid.2011.417.
- Grice E., Segr J. The skin microbiome. Nat Rev Microbiol. 2011;9(4):244-253. doi: 10.1038/nrmicro2537.
- Аравийская ЕР, Соколовский Е.В. Микробиом: новая эра в изучении здоровой и патологически измененной кожи. Вестник дерматологии и венерологии. 2016;(3):102-109
- Prescott SL, Larcombe DL, Logan AC, West C., Burks W., Caraballo L. The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming. World Allergy Organ J. 2017:22;10:29. doi: 10.1186/s40413-017-0160-5.
- Джораева СК, Гончаренко ВВ, Щеголева ЕВ, Щербакова ЮВ, Безрученко А.А. Состав и функции микробиоценозов различных биотопов макроорганизма и клиническая значимость их нарушений. Дерматология и венерология. 2015;2:5-19
- Сергеев АЮ, Бурцева ГН, Сергеев В.Ю. Стафилококковая колонизация кожи, антибиотикорезистентность и противомикробная терапия при распространенных дерматозах. Иммунопатология, аллергология, инфек-тология. 2014;4:42-55
- Lee HJ, Jeong SE, Lee S., Kim S., Han H., Jeon CO. Effects of cosmetics on the skin microbiome of facial cheeks with different hydration levels. Microbiology Open. 2018;7:e557. DOI: org/10.1002/mbo3.557.
- Seite S., Flores G., Henley J., Martin R., Zelenkova H., Aguilar L. Microbiome of affected and unaffected skin of patients with atopic dermatitis before and after emollient treatment. J. Drugs Dermatol. 2014;13(11):1365-1372.
- Biedermann T. Dissecting the role of infections in atopic dermatitis. Acta Derm Venerol. 2006;86(2):99-109.
- Pascolini C. Molecular and immunological characterization of Staphylococcus aureus in pediatric atopic dermatitis: implications for prophylaxis and clinical management. Clin Dev Immunol. 2011;2011:718708. doi: 10.1155/2011/718708.
- Bieber T. Atopic dermatitis. Ann Dermatol. 2010;22(2):125-137. doi: 10.5021/ad.2010.22.2.125.
- Стукова ЕИ, Кениксфест Ю.В. Патогенетическое значение золотистого стафилококка при атопическом дерматите. Фундаментальные исследования. 2013;7(3):680-687
- Кудрявцева АВ. Нарушение кожного барьера как ведущий фактор формирования местного воспалительного процесса при атопическом дерматите. Вестник дерматологии и венерологии. 2017;4:82-89
- Baviera G, Leoni MC, Capra L, Cipriani F, Longo G, Maiello N. Microbiota in healthy skin and in atopic eczema. Biomed Res Int. 2014;2014:436921. doi: 10.1155/2014/436921.
- Wollina U. Microbiome in atopic dermatitis. Clin Cosmet Investig Dermatol. 2017;10:51-56. doi: 10.2147/CCID. S130013.
