IgE and IgG4-autoantibodies in patients with bronchial asthma

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Abstract

The aim. Special interest has been recently noted in the autoreactivity as one of the mechanisms of bronchial asthma (BA) pathogenesis. The purpose of the study was to determine levels of IgE- and IgG4-autoantibodies (autoAbs) to tissue antigens (Ag) - keratin, collagen III and VI types, myosin and elastin using adapted ELISA method in blood serum of 88 patients with bronchial asthma (BA) of different severity and clinical course. Results. We determined that in patients with BA the quantitative levels and frequency of Ig-EautoAbs to all those Ags were significantly enhanced and were more prominent in severe (59-81%) than in mild and moderate BA (p<0.05) and were decreased during BA exacerbation. We also found increased frequency of detection and higher levels of IgE-Abs in long-term disease natural course (more than 5 years). The levels of IgG4-Abs to all listed Ags in patients with asthma was also enhanced compared with healthy people, but its levels oppositely decreased as the disease severity worsened. The frequency of elevated IgG4-autoAbs had higher prevalence among patients with mild BA. Direct correlation between the IgG-4autoAbs and IL-10 in the serum of patients with BA mild and moderate severity was indicated. Conclusions. IgE-autoAbs, when detected in patients with asthma, reflect the degree of lung tissue alterations and correlate with the disease severity, while IgG4-autoAT could indicate the functional activity of immune regulatory mechanisms.

About the authors

V B Gervazieva

Mechnikov Research Institute for Vaccines and Sera

Email: vbger@mail.ru
доктор медицинских наук, профессор, зав. лабораторией аллергодиагностики

A Yu Konishcheva

Mechnikov Research Institute for Vaccines and Sera

кандидат медицинских наук, в.н.с. лаборатории аллергодиагностики

P V Samoilikov

Mechnikov Research Institute for Vaccines and Sera

кандидат медицинских наук, с.н.с. лаборатории аллергодиагностики

O O Magarshak

Mechnikov Research Institute for Vaccines and Sera

кандидат медицинских наук, с.н.с. лаборатории вакцинопрофилактики и иммунотерапии аллергических заболеваний

S A Mazurina

Mechnikov Research Institute for Vaccines and Sera

кандидат биологических наук, в.н.с. лаборатории аллергодиагностики

V V Sveranovskaya

Mechnikov Research Institute for Vaccines and Sera

кандидат медицинских наук, в.н.с. лаборатории аллергодиагностики

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