Solid tumors’ metastasis mechanisms into the brain
- Authors: Sklyar S.S.1, Safarov B.I.1, Trashkov A.P.2, Zorina E.Y.3, Konova A.M.3, Kushnirova V.S.1, Kukanov K.K.1, Nechaeva A.S.1, Olyushin V.E.1, Samochernykh K.A.1, Vasiliev A.G.4, Vasilieva A.V.4
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Affiliations:
- Polenov Russian Neurosurgical Institute — the branch of Almazov National Medical Research Centre
- National Research Center “Kurchatov Institute”
- Almazov National Medical Research Centre
- Saint Petersburg State Pediatric Medical University
- Issue: Vol 14, No 6 (2023)
- Pages: 59-69
- Section: Reviews
- URL: https://journals.rcsi.science/pediatr/article/view/256910
- DOI: https://doi.org/10.17816/PED626396
- ID: 256910
Cite item
Abstract
The engineering and introduction into clinical practice of innovative methods of therapy patients with malignant tumors over the past two decades has certainly led to a significant increase in survival, which does not imply a “cure”, but the fact that more and more patients will live to the stage of metastasis to the central nervous system. The data obtained during diagnostic magnetic resonance imaging in recent years indicates a tendency to increase the number of cases of secondary brain damage in patients with various oncopathologies. Metastasis in the central nervous system is an actual problem due to the fact that the annual survival rate remains very low even with specific antitumor therapy (20 %). The study of the mechanisms of metastasis in the central nervous system is a key factor in the development of new effective approaches to the treatment of patients with this pathology, and, as a result, will lead to an improvement in the prognosis in this group of patients. Due to the analysis of the scientific literature on this issue, we have formulated and presented a modern understanding of the processes occurring in secondary brain damage. Special attention is devoted to organotropism, the mechanism of escape of metastatic cells from the immune system of the central nervous system and interaction with nerve cells, as well as the features of the extracellular matrix of the metastasis. Promising treatment methods being developed are presented.
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##article.viewOnOriginalSite##About the authors
Sofia S. Sklyar
Polenov Russian Neurosurgical Institute — the branch of Almazov National Medical Research Centre
Author for correspondence.
Email: s.sklyar2017@yandex.ru
ORCID iD: 0000-0002-3284-9688
SPIN-code: 4679-3548
MD, PhD, Senior Researcher of Research Laboratory of Neurooncology
Russian Federation, Saint PetersburgBobir I. Safarov
Polenov Russian Neurosurgical Institute — the branch of Almazov National Medical Research Centre
Email: safarovbob@mail.ru
ORCID iD: 0000-0002-2369-7424
MD, PhD, Head of 4th Department Neurooncology
Russian Federation, Saint PetersburgAlexandr P. Trashkov
National Research Center “Kurchatov Institute”
Email: alexandr.trashkov@gmail.com
ORCID iD: 0000-0002-3441-0388
SPIN-code: 4231-1258
MD, PhD, Head of the Neurocognitive Research Resource Center
Russian Federation, MoscowEkaterina Yu. Zorina
Almazov National Medical Research Centre
Email: bryk74@mail.ru
ORCID iD: 0000-0002-5928-9625
SPIN-code: 3132-7676
MD, PhD, oncologist of Department of Surgical Methods of Treatment of Patients with a Cancer
Russian Federation, Saint PetersburgAleksandra M. Konova
Almazov National Medical Research Centre
Email: alex79696@mail.ru
ORCID iD: 0009-0004-7104-8447
oncologist of Department of Surgical Methods of Treatment of Patients with a Cancer
Russian Federation, Saint PetersburgVictoria S. Kushnirova
Polenov Russian Neurosurgical Institute — the branch of Almazov National Medical Research Centre
Email: victoria.kushnirova@mail.ru
ORCID iD: 0000-0003-0480-0884
SPIN-code: 9105-5852
neurosurgeon
Russian Federation, Saint PetersburgKonstantin K. Kukanov
Polenov Russian Neurosurgical Institute — the branch of Almazov National Medical Research Centre
Email: kukanov_kk@almazovcentre.ru
ORCID iD: 0000-0002-1123-8271
SPIN-code: 8938-0675
MD, PhD, Senior Researcher of Research Laboratory of Neurooncology
Russian Federation, Saint PetersburgAnastasiia S. Nechaeva
Polenov Russian Neurosurgical Institute — the branch of Almazov National Medical Research Centre
Email: nastja-nechaeva00@mail.ru
ORCID iD: 0000-0001-9898-5925
SPIN-code: 2935-0745
Junior Researcher of Research Laboratory of Neurooncology
Russian Federation, Saint PetersburgViktor E. Olyushin
Polenov Russian Neurosurgical Institute — the branch of Almazov National Medical Research Centre
Email: fed_56@mail.ru
ORCID iD: 0000-0002-9960-081X
MD, PhD, Dr. Sci. (Medicine), Professor, Chief Scientific officer Research Laboratory of Neurooncology
Russian Federation, Saint PetersburgKonstantin A. Samochernykh
Polenov Russian Neurosurgical Institute — the branch of Almazov National Medical Research Centre
Email: samochernykh_ka@almazovcentre.ru
ORCID iD: 0000-0003-0350-0249
SPIN-code: 4188-9657
Scopus Author ID: 24280115200
ResearcherId: AAS-7689-2020
Dr. Sci. (Medicine), professor, Director
Russian Federation, Saint PetersburgAndrei G. Vasiliev
Saint Petersburg State Pediatric Medical University
Email: avas7@mail.ru
ORCID iD: 0000-0002-8539-7128
SPIN-code: 1985-4025
MD, PhD, Dr. Sci. (Medicine), Professor, Head of Pathophysiology Department
Russian Federation, Saint PetersburgAnna V. Vasilieva
Saint Petersburg State Pediatric Medical University
Email: a-bondarenko@yandex.ru
ORCID iD: 0009-0008-2356-1552
SPIN-code: 5333-0144
Assistant of the Department of Pathological Physiology with the Course of Immunopathology
Russian Federation, Saint PetersburgReferences
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