The benefits of primary prevention of colorectal cancer around the age of 20 compared to secondary prevention after the age of 50

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Abstract

The major advantages of primary prevention of colorectal cancer in young adults (around 20 years) compared with se condary prevention in adults (after 50 years). Primary prevention is aimed at screening and eliminating one of the major proven risk factors for colon cancer – chronic constipation and its predecessor – colorectal bradyarrhythmia – as slower circadian rhythm of defecation. The main advantages of primary prevention of colorectal cancer are: non-invasiveness, safety, efficiency and timeliness. Screening of colorectal bradyarrhythmia at 2501 operating physician is allowed to diagnose this arrhythmia in 44% of the surveyed entities. There is discovered the new fundamental dependence between the regularity of circadian rhythm of defecation and an acrophase of this rhythm. The implementation of the morning acrophase of the circadian rhythm of defecation is the key mechanism of the regularity of this rhythm. Repeated screening of colorectal bradyarrhythmia in individuals around the age of 20 years (a month after informing students about the law of circadian rhythm in the brain and intestine) showed that 53% of the students began to observe the morning routine of bowel movements. This led to a transition of moderate stage of colorectal bradyarrhythmia severity (3-4 times a week) in an easy stage (5-6 times a week). It’s proved the possibility of primary (behavioral) prevention of colorectal bradyarrhythmia (colorectal coprostasis) as a risk factor for colorectal cancer. Secondary prevention of colon cancer is associated with the invasiveness of colonoscopy, its possible complications (bleeding, perforation of bowel and fatal outcomes), the high cost of special equipment and late in the approach to screening for colorectal cancer (after the appearance of blood in the stool or after 50 years).

About the authors

Konstantin A. Shemerovskii

Institute of Experimental Medicine

Author for correspondence.
Email: constshem@yandex.ru

MD, PhD, Dr Med Sci. Department of Physiology of Visceral Systems n.a. K.M. Bykov

Russian Federation, Saint Petersburg

Petr D. Shabanov

Institute of Experimental Medicine

Email: pdshabanov@mail.ru

MD, PhD, Dr Med Sci, Professor, Head. Department of Neuropharmacology n.a. S.V. Anichkov

Russian Federation, Saint Petersburg

Vladimir Ph. Mitreikin

Academician I.P. Pavlov First St Petersburg State Medical University 

Email: mvphch2742@mail.ru

MD, PhD, Dr Med Sci, Professor. Department of Pathological Physiology

Russian Federation, Saint Petersburg

Pavel V. Seliverstov

North-Western State Medical University named after I.I. Mechnikov

Email: seliverstov-pv@yandex.ru

MD, PhD Associate, Professor. Department of Internal Diseases and Nephrology

Russian Federation, Saint Petersburg

Andrei Yu. Iurov

St. Petersburg State Pediatric Medical University

Email: ayroot@mail.ru

PhD, Associate Professor, Department of Human Physiology

Russian Federation, Saint Petersburg

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Copyright (c) 2018 Shemerovskii K.A., Shabanov P.D., Mitreikin V.P., Seliverstov P.V., Iurov A.Y.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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