Risk factors of progression of chronic kidney disease in children with congenital malformations of the urinary tract in the postoperative period

Cover Page

Cite item

Full Text

Abstract

The aim of the study is the identification of independent predictors of progression of chronic kidney disease (CKD) in children operated on for congenital malformations of the urinary tract (CMUT).

Methods. Study design – retrospective, observational, cohort. Inclusion criteria were CMUT, glomerular filtration rate (GFR) <90 ml/min/1.73 m2. Age younger than 18 years of age. The study included 297 patients. Statistical processing of research results was carried out using the software package Statistica 6.0. and MedCalc (MedCalc Software, Belgium).

Results. We identified that only glomerular filtration rate during the initial hospitalization (ОR = 9.40) and arterial hypertension (OR = 4.40) were independent predictors of CKD progression. The combination of these two variant showed the area under the ROC curve (0.756), significantly (p < 0.005) higher than the isolated value of these symptoms.

About the authors

Rustem Z Ahmetshin

Bashkortostan State Medical University, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: rz47@rambler.ru

PhD, chief of the Department of Pediatrics IDPO

Russian Federation, Ufa, Russia

I Lutfarahmanov Ildar

Bashkortostan State Medical University, Ministry of Healthcare of the Russian Federation

Email: orit@mail333.com

D.Med.Sc., Professor, Chief of the Department of Anesthesiology and Intensive Care

Russian Federation, Ufa, Russia

Ivanovich Mironov Petr

Bashkortostan State Medical University, Ministry of Healthcare of the Russian Federation

Email: mironovpi@mail.ru

D.Med.Sc., Professor of the Department of Pediatric Surgery

Russian Federation, Ufa, Russia

References

  1. Александрович Ю.С., Пшениснов К.В. Сердечно-легочная реанимация в педиатрической практике: основы и изменения 2015 года // Педиатр. – 2016. – Т. 7. – № 1. – С. 5–15. [Aleksandrovich YuS, Pshenisnov KV. Modern principles of cardiopulmonary resuscitation in pediatric practice. Pediatr. 2016;7(1):5-15. (In Russ.)]
  2. Александрович Ю.С., Пшениснов К.В., Гордеев В.И. Интенсивная терапия критических состояний у детей. – СПб.: изд-во «Н-Л», 2014. [Aleksandrovich JuS, Pshenisnov KV, Gordeev VI. Intensive care of critical states at children. Saint Petersburg: N-L; 2014. (In Russ.)]
  3. Александрович Ю.С., Гордеев В.И. Оценочные и прогностические шкалы в медицине критических состояний. – СПб.: ЭЛБИ-СПб, 2015. [Aleksandrovich JuS, Gordeev VI. Rating and prognostic scales in medicine of critical states. Saint Petersburg: ELBI-SPb; 2015. (In Russ.)]
  4. Нефрология детского возраста / Под ред. В.А. Таболина, С.В. Бельмера, И.М. Османова. – М.: Медпрактика, 2005. – 712 с. [Nephrology children's age. Ed by V.A. Tabolina, S.V. Belmer, I.M. Osmanov. Moscow: Medpraktika; 2005. (In Russ.)]
  5. Паршин Е.В., Александрович Ю. С., Кушнерик Л.А., и др. Показатели кислородного статуса как маркеры дисфункции почек у новорожденных в критическом состоянии // Общая реаниматология. –2010. – Т. 1. – № 2. – С. 62–67. [Parshin EV, Aleksandrovich JuS, Kushnerik LA, et al. Oxygen status parameters as markers of renal dysfunction in neonatal infants with critical status. Obshhaja reanimatologija. 2010;1(2):62-67. (In Russ.)]
  6. Урология. Национальное руководство / под ред. Н.А. Лопаткина. – M.: ГЭОТАР-Медиа, 2009. – 1071 с. [Urology. The national guidance. Ed by N.A. Lopatkina. Moscow: GEOTAR-Media; 2009. 1071 p. (In Russ.)]
  7. Chiu HL, Tangri N, Djurdiev O, et al. Perceptions of prognostic risks in chronic kidney disease: a national survey. Canadian J of Kidney Health And Disease. 2015;2:53.
  8. Dupius D, Ducllet G, Roy L. Retrospective analysis of the predictive factors of renal functions loss after uninephroectomy in patients with chronic kidney disease G3 to G5. Canadian J of Kidney Health And Disease. 2015;2:52.
  9. Heinlen JE, Manatt CS, Bright BC, et al. Operative versus nonoperative management of ureteropelvic junction obstruction in children. Urology. 2009;73(3):521e5.
  10. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidnei International Supll. 2013;(1):163.
  11. Ross SS, Kordos S, Krill A, et al. Observation of infant with SFU Grades 3-4 hydronephrosis: Worsening drainage with serial diuresis renography indicates surgical intervention and help prevent loss renal function. J Pediatric Urology. 2011;7:266-271. doi: 10.1016/j.jpurol.2011.03.001.
  12. Shahinian VB, Hedgeman E, Gillespie BW, et al. Estimating prevalence of CKD stages 3-5 using health system data. Am J Kidney Dis. 2013;61(6):930-8. doi: 10.1053/j.ajkd.2013.01.018.

Copyright (c) 2017 Ahmetshin R.Z., Ildar I.L., Petr I.M.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies