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Post a Comment The role of secretary-motor stomach disorders in the genesis of atopic dermatitis in children
- Authors: Buryak V.N.1, Antonova T.I.2, Malysheva I.V.2, Shepelenko K.K.2, Dudko M.V.2, Peshekhonova Y.V.2, Buryak N.V.3
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Affiliations:
- North-Western State Medical University named after I.I. Mechnikov
- Children’s City Polyclinic No. 35
- Donetsk National Medical University named after M. Gorky
- Issue: Vol 11, No 1 (2020)
- Pages: 13-18
- Section: Original studies
- URL: https://journals.rcsi.science/pediatr/article/view/33850
- DOI: https://doi.org/10.17816/PED11113-18
- ID: 33850
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Abstract
Objective: to study the relationship of the main mediators of atopy and clinical and morphological characteristics lesions of the stomach with its secretory-motor disorders in children with atopic dermatitis. We study 134 patients aged 7 to 14 years with atopic dermatitis and 30 healthy children as control group. All children passed general clinical and laboratory instrumental investigations. In addition, children with manifestations of atopic dermatitis and secretory-motor disorders of the stomach Fibroesophagogastroduodenoscopy, topographic intragastric pH-metry with aspiration biopsy of the gastric mucosa were performed, followed by morphological investigations. In sick children, an increase in the levels of total IgE, histamine and serotonin was detected in the blood, combined with a tendency to decrease acid-forming function, endoscopic and morphological changes in the gastric mucosa. It is assumed that concomitant atopic dermatitis secretory-motor disorders of the stomach are manifestations of gastrointestinal syndrome, which can be both secondary and primary in relation to skin manifestations and in both situations contribute the formation of endoallergens and maintain a vicious cycle of the pathological process.
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##article.viewOnOriginalSite##About the authors
Vladimir N. Buryak
North-Western State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: vladimir.buryak@inbox.ru
MD, PhD, Dr Med Sci, Professor, Department of Pediatrics and Pediatric Cardiology
Russian Federation, Saint PetersburgTatyana I. Antonova
Children’s City Polyclinic No. 35
Email: antian@bk.ru
MD, PhD, Head
Russian Federation, Saint PetersburgInna V. Malysheva
Children’s City Polyclinic No. 35
Email: inness6996@yandex.ru
Allergologist
Russian Federation, Saint PetersburgKirill K. Shepelenko
Children’s City Polyclinic No. 35
Email: shess08@inbox.ru
Allergologist
Russian Federation, Saint PetersburgMaria V. Dudko
Children’s City Polyclinic No. 35
Email: maria.dudko17@gmail.com
Allergologist
Russian Federation, Saint PetersburgYulia V. Peshekhonova
Children’s City Polyclinic No. 35
Email: peshekhonova@mail.ru
MD, PhD, Allergologist
Russian Federation, Saint PetersburgNikolay V. Buryak
Donetsk National Medical University named after M. Gorky
Email: vladimir.buryak@inbox.ru
Student, 3rd Year, Pediatric Faculty
DonetskReferences
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