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Post a Comment The importance of antiangiogenic substances endoglin and sFLT-1, as well as endogenous digitalis-like factor marinobufagenin in the pathogenesis of preeclampsia
- Authors: Reznik V.A.1, Ivanov D.O.1, Ruhlyada N.N.1, Tapilskaya N.I.1, Ershov I.A.1
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Affiliations:
- St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
- Issue: Vol 11, No 1 (2020)
- Pages: 5-12
- Section: Editorial
- URL: https://journals.rcsi.science/pediatr/article/view/33849
- DOI: https://doi.org/10.17816/PED1115-12
- ID: 33849
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Abstract
Objective. Establish the relationship between the action of antiangiogenic factors sFLT-1 and endoglin, as well as marinobufagenin in the formation of symptoms of preeclampsia in the clinic and experiment.
Materials and methods. In the first experimental phase, preeclampsia-like state was simulated in pregnant rats, the changes in the content of substances reflected in the target tissues were studied, as well as the effect on their concentrations of anti-marinobufagenin antibodies. In the second (clinical) phase, changes in the content of sFlt-1 and endoglin-1 in placental tissues, as well as marinobufagenin in blood plasma and activity of Na+/K+-ATPase of erythrocytes in pregnant women with preeclampsia were studied.
Results. In rats, an increase in systolic blood pressure, and marinobufagenin plasma levels was observed during the formation of a preeclampsia-like condition. Administration of antibodies to marinobufagenin caused a decrease in blood pressure. Found that during the formation of a preeclampsia-like condition, there is an increase in the content of sFlt-1 in the placenta and thoracic aorta and endoglin in the placenta. In patients with preeclampsia, it was found that the increase in blood pressure occurs against the background of an increase in the content of marinobufagenin in blood plasma, as well as a decrease in the activity of Na+/K+-ATPase of erythrocytes. The formation of preeclampsia is accompanied by a significant increase in the level of antiangiogenic factors endoglin and sFlt-1 in the placenta.
Summary. In patients with preeclampsia, the development of clinical symptoms is accompanied by an increase in the placental tissues of the content of antiangiogenic factors endoglin and sFlt-1 and the content of marinobufagenin in blood plasma. The obtained data are confirmed by the results of an experiment performed on pregnant rats with modeling of preeclampsia-like condition.
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##article.viewOnOriginalSite##About the authors
Vitaly A. Reznik
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: vitaliy-reznik@mail.ru
MD, PhD, Associate Professor, Head Physician on Obstetrics and Gynecology
Russian Federation, St. PetersburgDmitry O. Ivanov
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: doivanov@yandex.ru
MD, PhD, Dr Med Sci, Professor, Rector
Russian Federation, St. PetersburgNikolaj N. Ruhlyada
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: nicolasr@mail.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of Obstetrics and Gynecology
Russian Federation, St. PetersburgNatal’ya I. Tapilskaya
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: tapnatalia@yandex.ru
MD, PhD, Dr Med Sci, Professor, Department of Obstetrics and Gynecology
Russian Federation, St. PetersburgIvan A. Ershov
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: ershov@yandex.ru
Resident Physician, Department of Obstetrics and Gynecology
Russian Federation, St. PetersburgReferences
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