Diagnosis and treatment of infection specific to the perinatal period (Draft clinical recommendations for discussion by neonatologists and pediatricians)

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Abstract

Perinatal infections occupy a leading place among the causes of neonatal morbidity, maternal and perinatal mortality. Infections are among the main causes of termination of pregnancy and premature birth. The practical recommendations presented in the work are intended for doctors of obstetric institutions in order to make a clinical diagnosis of an infection specific to the perinatal period, the tactics of examination and treatment of newborn children. The clinical recommendations correspond to the latest scientific data on the topic, contain information that is applied to the practical activities of a neonatologist, intensive care specialist and pediatrician. These clinical recommendations contain information about infections specific to the perinatal period, including the definition, frequency of occurrence, etiology of infections, pathogenetic mechanisms of disease development Numerous high-risk factors for infection of the fetus and newborn are described in detail. The document discusses and proposes the classification of the disease, the criteria for the adoption of the diagnosis. The features of the clinical picture of the disease are described, it is noted that the inflammatory process in a newborn child can be localized in any organ or acquire a systemic (generalized) character, in some cases, the ingress of an infectious agent into a macroorganism is not necessarily accompanied by clinical manifestations, which indicates an asymptomatic or subclinical course of infection. The recommendations provide advanced laboratory and instrumental diagnostics. The stages of treatment are described, including the choice and correction of antibacterial therapy, taking into account the peculiarities of the mother’s anamnesis, the child’s gestation period and the etiology of the disease. These clinical recommendations have been prepared taking into account the level of credibility of the recommendations and the level of reliability of the evidence.These practical recommendations are offered for public discussion and are posted in full on the website of the Ministry of Health of the Russian Federation.

About the authors

Dmitry O. Ivanov

Saint Petersburg State Pediatric Medical University

Email: delopro@gpmu.org.ru
ORCID iD: 0000-0002-0060-4168
SPIN-code: 4437-9626

MD, PhD, Dr. Sci. (Medicine), Professor, Chief neonatologist of the Ministry of Health of the Russian Federation, Head of the Department of Neonatology with Сourses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education, Rector

Russian Federation, Saint Petersburg

Alexandra S. Panchenko

Saint Petersburg State Pediatric Medical University

Author for correspondence.
Email: sashawomen18@mail.ru
ORCID iD: 0000-0003-2313-3941
SPIN-code: 9552-2350

MD, PhD, Dr. Sci. (Medicine), Professor of the Department of Neonatology with courses of Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

Russian Federation, Saint Petersburg

Larisa A. Fedorova

Saint Petersburg State Pediatric Medical University

Email: arslarissa@rambler.ru
ORCID iD: 0000-0001-9747-762X
SPIN-code: 5474-0902

MD, PhD, Associate Professor of the Department of Neonatology with courses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

Russian Federation, Saint Petersburg

Ekaterina N. Balashova

Research Center for Obstetrics, Gynecology and Perinatology

Email: katbal99@gmail.com
ORCID iD: 0000-0002-3741-0770
SPIN-code: 1335-1489

MD, PhD, Assistant of the Department of Neonatology

Russian Federation, Moscow

Elena V. Bem

Saint Petersburg State Pediatric Medical University

Email: e.bohm@inbox.ru
ORCID iD: 0009-0008-9337-5667
SPIN-code: 2811-5938

MD, PhD, Assistant of the Department of Neonatology with courses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

Russian Federation, Saint Petersburg

Nazar M. Zelenin

Saint Petersburg State Pediatric Medical University

Email: Piorun1944@gmail.com
SPIN-code: 1101-2442

anesthesiologist-resuscitator, Head of the Department

Russian Federation, Saint Petersburg

Irina V. Myznikova

Saint Petersburg State Pediatric Medical University

Email: irinayurko2014@yandex.ru
ORCID iD: 0000-0002-8624-1854

Head of the Department of Pathology of Newborns and Young Children of the Perinatal Center, Assistant of the Department of Neonatology with courses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

Russian Federation, Saint Petersburg

Marina I. Levadneva

Saint Petersburg State Pediatric Medical University

Email: m-lev11@yandex.ru
ORCID iD: 0000-0001-6716-7567
SPIN-code: 2780-6674

Head of the Department of Newborn Physiology at the Perinatal Center, Assistant of the Department of Neonatology with Сourses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

Russian Federation, Saint Petersburg

Anna S. Nabieva

Saint Petersburg State Pediatric Medical University

Email: hamatum@bk.ru
ORCID iD: 0000-0002-2519-7589
SPIN-code: 4579-1621

MD, PhD, Head of the Epidemiological Department

Russian Federation, Saint Petersburg

Svetlana E. Pavlova

Saint Petersburg State Pediatric Medical University

Email: svetlanapav.spb@mail.ru
ORCID iD: 0000-0001-5423-0950
SPIN-code: 1761-4768

Assistant Professor of the Department of Neonatology with courses of Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

Russian Federation, Saint Petersburg

Larisa A. Romanova

Saint Petersburg State Pediatric Medical University

Email: l_romanova2011@mail.ru
ORCID iD: 0000-0003-0828-352X
SPIN-code: 6460-5491

MD, PhD, Associate Professor of the Department of Neonatology with courses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

Russian Federation, Saint Petersburg

Galina N. Chumakova

Saint Petersburg State Pediatric Medical University

Email: zelchum-neo@yandex.ru
ORCID iD: 0000-0001-5353-4610
SPIN-code: 1821-0198

MD, PhD, Dr. Sci. (Medicine), Professor of the Department of Neonatology with courses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

Russian Federation, Saint Petersburg

Ekaterina E. Yakovleva

Saint Petersburg State Pediatric Medical University

Email: eeiakovleva@mail.ru
ORCID iD: 0000-0002-0270-0217
SPIN-code: 6728-7340

MD, PhD, Head of the Department of Clinical Pharmacology, Associate Professor of the Department of Pharmacology with the course of Clinical Pharmacology and Pharmacoeconomics

Russian Federation, Saint Petersburg

Tamara V. Belousova

Novosibirsk State Medical University

Email: belousovatv03@yandex.ru
ORCID iD: 0000-0002-4234-9353
SPIN-code: 9651-0155

MD, PhD, Dr. Sci. (Medicine), Professor, Honored Doctor of Russia, Head of the Department of Pediatrics and Neonatology

Russian Federation, Novosibirsk

Irina Y. Izvekova

Novosibirsk State Medical University

Email: izvekova@inbox.ru
ORCID iD: 0009-0003-6617-6797

MD, PhD, Dr. Sci. (Medicine), Professor of the Department of Infectious Diseases

Russian Federation, Novosibirsk

Dmitry Y. Ovsyannikov

Peoples’ Friendship University of Russia

Email: mdovsyannikov@yahoo.com
ORCID iD: 0000-0002-4961-384X
SPIN-code: 5249-5760

MD, PhD, Dr. Sci. (Medicine), Head of the Department of Pediatrics

Russian Federation, Moscow

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