Email this article 
Post a Comment Collagens of placenta composition in obese puerperant women who gave birth to сhildren at St. Petersburg State Pediatric Medical University in 2018–2021
- Authors: Petrenko Y.V.1, Ivanov D.O.1, Polyakova V.O.2, Novikova V.P.1, Fedotova E.P.1, Demchenkova O.A.1, Levadneva M.I.1, Tarkhanova E.B.1
-
Affiliations:
- Saint Petersburg State Pediatric Medical University
- Saint Petersburg State Research Institute of Phthisiopulmonology
- Issue: Vol 15, No 1 (2024)
- Pages: 29-36
- Section: Original studies
- URL: https://journals.rcsi.science/pediatr/article/view/263091
- DOI: https://doi.org/10.17816/PED15129-36
- ID: 263091
Cite item
Open Access
Access granted
Subscription Access
Abstract
BACKGROUND: The relevance of the problem of obesity is associated with the high frequency and steady growth of this pathology in the population. The epigenetic influence of maternal obesity on the course of pregnancy and childbirth, as well as on the condition of the fetus and newborn, is currently being studied. This article analyzes changes in the composition of the connective tissue of the placenta against the background of obesity in pregnant and puerperas.
AIM: The aim of this study is to identify the pathomorphological features of the placenta and the composition of placental collagens in women who were obese before pregnancy and at the time of delivery at the Perinatal Center of St. Petersburg State Medical University from 2018 to 2021 to assess potential fetal risks and to predict possible complications during pregnancy and in the postnatal period for the mother.
MATERIALS AND METHODS: A histological examination of the placentas of obese women (18 patients) and the ones with a normal body mass index (18 patients) who gave birth to mature newborns at the Perinatal Center of St. Petersburg State Medical University from 2018 to 2021 was performed followed by immunohistochemical examination. Staining of placenta specimens was carried out in accordance with the standard immunohistochemical protocol, using primary antibodies to type I–IV collagen.
RESULTS: Microscopic examination of chorionic villi revealed no significant differences in the presence of chronic inflammation and angiogenesis disorders between the groups. When studying collagen expression levels, the following differences have been found: in the group of pregnant obese patients, the optical luminescence density and distribution area for type I–III collagen in the placenta were significantly higher, while for type IV collagen they were significantly lower compared with the control group.
CONCLUSIONS: The following features of the formation of connective tissue in the placenta in obese mothers have been revealed: an increase in type I–III collagen production and a decrease in type IV collagen production. The obtained findings indicate an earlier functional and morphological change in the placenta than those detected by standard histological methods.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Yuriy V. Petrenko
Saint Petersburg State Pediatric Medical University
Email: alez1964@yandex.ru
ORCID iD: 0000-0002-8623-4574
SPIN-code: 1644-1394
MD, PhD, Associate Professor, Department of Neonatology with Сourses in Neurology and Obstetrics-Gynecology, Faculty of the Postgraduate and Additional Professional Education
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Dmitry O. Ivanov
Saint Petersburg State Pediatric Medical University
Email: doivanov@yandex.ru
ORCID iD: 0000-0002-0060-4168
SPIN-code: 4437-9626
MD, PhD, Dr. Sci. (Medicine), Professor, Chief Freelance Neonatologist of the Ministry of Health of Russia, Rector, Head of the Department of Neonatology with courses of Neurology and Obstetrics and Gynecology of the Postgraduate and Additional Professional Education
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Victoria O. Polyakova
Saint Petersburg State Research Institute of Phthisiopulmonology
Email: vopol@yandex.ru
ORCID iD: 0000-0001-8682-9909
SPIN-code: 5581-5413
PhD, Professor, Professor of the Russian Academy of Sciences, Deputy Director for Science
Russian Federation, Saint PetersburgValeria P. Novikova
Saint Petersburg State Pediatric Medical University
Author for correspondence.
Email: novikova-vp@mail.ru
ORCID iD: 0000-0002-0992-1709
SPIN-code: 1875-8137
MD, PhD, Dr. Sci. (Medicine), Head of the Department, Department of Propaedeutics of Childhood Diseases with a course of general child care
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Elena P. Fedotova
Saint Petersburg State Pediatric Medical University
Email: Kris6060@mail.ru
ORCID iD: 0000-0002-2975-1014
MD, PhD, Associate Professor, Department of Pathological Anatomy with a Course of Forensic Medicine named after D.D. Lokhov
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Olga A. Demchenkova
Saint Petersburg State Pediatric Medical University
Email: dnwhelga@list.ru
ORCID iD: 0000-0003-2686-5785
SPIN-code: 5092-4778
Laboratory Assistant, Department of Propaedeutics of Childhood Diseases with a course of general child care
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Marina I. Levadneva
Saint Petersburg State Pediatric Medical University
Email: m-lev11@yandex.ru
ORCID iD: 0000-0001-6716-7567
SPIN-code: 2780-6674
Head, Department of Neonatal Physiology, Perinatal Center, Pediatric University Clinic
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Elena B. Tarkhanova
Saint Petersburg State Pediatric Medical University
Email: kasablanka85@list.ru
ORCID iD: 0000-0002-6338-2558
Neonatologist, Department of Neonatal Physiology, Perinatal Center, Pediatric University Clinic
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100References
- Abdulkhabirova FM, Abrosimov AYu, Aleksandrova GF, et al. Endocrinology: Russian clinical recommendations. Moscow: GEOTAR-Media, 2016. 592 p. EDN: YPFEXX (In Russ.)
- Burkitova AM, Polyakov VO, Bolotskikh VM, Kvetnoy IM. Features of the placenta structure in post-term pregnancy. Journal of Obstetrics and Womans Diseases. 2019;68(6):73–86. EDN: TAGSLQ doi: 10.17816/JOWD68673-86
- Voloshchuk IN. Morphologic bases and pathogenesis of placental insufficiency. [dissertation abstract]. Moscow; 2002. 48 p. (In Russ.) EDN: NHGWNN
- Gritsinskaya VL, Novikova VP, Khavkin AI. On the epidemiology of underweight in children and adolescents (systematic review and meta-analysis of scientific publications). Clinical Practice in Pediatrics. 2022; 17(2):126–135. EDN: BTFVGE doi: 10.20953/1817-7646-2022-2-126-135
- Krasnopolsky VI, Novikova SV, Saveliev SV, Barinova IV. Determination of the role of collagen in the formation of placental insufficiency. Russian Messenger of Obstetrician-Gynecologist. 2007;7(5):17–23. EDN: ICEIST
- Mazurov VI. Biochemistry of collagen proteins. Moscow: Medicine; 1974. 248 p. EDN: ZFXVSR (In Russ.)
- Novikova VP, Gurova MM. Multidisciplinary problems of obesity in children. Saint Petersburg; 2018. 582 p. EDN: YWKXOX
- Novikova SV, Savelyev SV. To the question of structural bases determining functional manifestations of placental insufficiency. Russian Journal of Woman and Child Health. 2014;22(14):1030. EDN: SKBOAV
- Novikova SV. Modern problems of delivery of women with fetoplacental insufficiency. [dissertation abstract]. Moscow 2005. 47 p. (In Russ.) EDN: NQCBMF
- Petrenko YuV, Prokopyeva NE, Kovaleva VV, Kovaleva VV. Features of adiponectin at the mother–placenta–fetus system. University Therapeutic Journal. 2023;5(3):41–49. EDN: MOHAVQ doi: 10.56871/UTJ.2023.42.20.004
- Petrenko YuV, Novikova VP, Polunina AV. Maternal obesity and child health at different ages. Pediatrician (St. Petersburg). 2018;9(3):24–27. EDN: RVJCIH doi: 10.17816/PED9324-27
- Petrenko YuV, Prokopeva NE, Ivanov DO, et al. Toward fetal programming of obesity in children. Forcipe. 2022;5(S2):399–400. EDN: EQKSVB (In Russ.)
- Petrova VD. Urinary incontinence in women (etiopathogenesis, clinic, diagnosis, treatment): [dissertation abstract]. Moscow; 2005. 48 p. (In Russ.) EDN: NQCJOZ
- Savelyev SV, Buyanova SN, Babunashvili EL, Mgeliashvili MV. Determination of the role of collagen type IV in the pathogenesis of uterine myoma. Russian Herald of Obstetrics and Gynecology. 2005;5(4):7–10. (In Russ.)
- Smirnova NN, Kuprienko NB, Novikova VP, Khavkin AI. Placenta as a target organ for maternal obesity. Gynecology, Obstetrics and Perinatology. 2021;20(5):93–99. EDN: WSJGRO doi: 10.20953/1726-1678-2021-5-93-99
- Smirnova NN, Kuprienko NB, Petrenko YuV, Novikova VP. Maternal obesity and the mother–placenta–fetus system: evidence-based mechanisms of influence. Children’s Medicine of the North-West. 2021;9(3):31–39. EDN: ZZIDYA
- Edu A, Teodorescu C, Dobjanschi CG, et al. Placenta changes in pregnancy with gestational diabetes. Rom J Morphol Embryol. 2016;57(2):507–512.
- Ortega MA, Asúnsolo Á, Álvarez-Rocha MJ, et al. Remodelling of collagen fibres in the placentas of women with venous insufficiency during pregnancy. Histol Histopathol. 2018;33(6):567–576. doi: 10.14670/HH-11-948
- Shi JW, Lai ZZ, Yang HL, et al. Collagen at the maternal-fetal interface in human pregnancy. Int J Biol Sci. 2020;16(12):2220–2234. doi: 10.7150/ijbs.45586
Supplementary files
