The study of hydrogen sulfide in cord blood to predict the functioning of the ductus arteriosus in preterm infants

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Abstract

The hemodynamically significant functioning ductus arteriosus in premature infants can cause many complications and worsen the prognosis for life and health. Therefore, the determination of a high risk of the functioning of the ductus arteriosus is an urgent problem of the early neonatal period. Characteristic echocardiographic manifestations of a functioning ductus arteriosus is a lower stroke volume, higher pressure in the pulmonary artery and aorta. In the framework of this study, the frequency of the functioning ductus arteriosus in deeply premature infants was revealed. It was found that the concentration of hydrogen sulfide in umbilical cord blood in lower preterm infants with a functioning arterial duct is lower than in newborns without a functioning arterial duct. It is shown that the concentration of hydrogen sulfide in cord blood can be used for early detection of this condition. A method for predicting the functioning of the arterial duct has been developed, which consists in calculating the prognostic index D taking into account the gestational age, weight and height of the newborn, as well as the concentration of hydrogen sulfide in cord blood.

About the authors

Natalya V. Kharlamova

Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation

Author for correspondence.
Email: nataliakhar13@yandex.ru

MD, PhD, Dr Med Sci, Leading Scientist, Pediatric Neonatology and Clinical Neurology Department

Russian Federation, Ivanovo

Julia A. Fisuk

Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation

Email: juliaf.26@mail.ru

Junior Researcher, Pediatric Neonatology and Clinical Neurology Department

Russian Federation, Ivanovo

Olga G. Sitnikova

Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation

Email: juliaf.26@mail.ru

PhD, Senior Researcher, Laboratory of Clinical Biochemistry and Genetics

Russian Federation, Ivanovo

Tatiana Z. Gorozhanina

Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation

Email: tagor411@mail.ru

MD, PhD, Department of Functional Diagnostics

Russian Federation, Ivanovo

Sergey B. Nazarov

Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation

Email: sergey@nazarov.ws

MD, PhD, Dr Med Sci, Professor, Head, Laboratory of Clinical Biochemistry and Genetics

Russian Federation, Ivanovo

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Copyright (c) 2020 Kharlamova N.V., Fisuk J.A., Sitnikova O.G., Gorozhanina T.Z., Nazarov S.B.

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