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Post a Comment The study of hydrogen sulfide in cord blood to predict the functioning of the ductus arteriosus in preterm infants
- Authors: Kharlamova N.V.1, Fisuk J.A.1, Sitnikova O.G.1, Gorozhanina T.Z.1, Nazarov S.B.1
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Affiliations:
- Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation
- Issue: Vol 10, No 5 (2019)
- Pages: 19-26
- Section: Original studies
- URL: https://journals.rcsi.science/pediatr/article/view/19150
- DOI: https://doi.org/10.17816/PED10519-26
- ID: 19150
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Abstract
The hemodynamically significant functioning ductus arteriosus in premature infants can cause many complications and worsen the prognosis for life and health. Therefore, the determination of a high risk of the functioning of the ductus arteriosus is an urgent problem of the early neonatal period. Characteristic echocardiographic manifestations of a functioning ductus arteriosus is a lower stroke volume, higher pressure in the pulmonary artery and aorta. In the framework of this study, the frequency of the functioning ductus arteriosus in deeply premature infants was revealed. It was found that the concentration of hydrogen sulfide in umbilical cord blood in lower preterm infants with a functioning arterial duct is lower than in newborns without a functioning arterial duct. It is shown that the concentration of hydrogen sulfide in cord blood can be used for early detection of this condition. A method for predicting the functioning of the arterial duct has been developed, which consists in calculating the prognostic index D taking into account the gestational age, weight and height of the newborn, as well as the concentration of hydrogen sulfide in cord blood.
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##article.viewOnOriginalSite##About the authors
Natalya V. Kharlamova
Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation
Author for correspondence.
Email: nataliakhar13@yandex.ru
MD, PhD, Dr Med Sci, Leading Scientist, Pediatric Neonatology and Clinical Neurology Department
Russian Federation, IvanovoJulia A. Fisuk
Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation
Email: juliaf.26@mail.ru
Junior Researcher, Pediatric Neonatology and Clinical Neurology Department
Russian Federation, IvanovoOlga G. Sitnikova
Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation
Email: juliaf.26@mail.ru
PhD, Senior Researcher, Laboratory of Clinical Biochemistry and Genetics
Russian Federation, IvanovoTatiana Z. Gorozhanina
Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation
Email: tagor411@mail.ru
MD, PhD, Department of Functional Diagnostics
Russian Federation, IvanovoSergey B. Nazarov
Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation
Email: sergey@nazarov.ws
MD, PhD, Dr Med Sci, Professor, Head, Laboratory of Clinical Biochemistry and Genetics
Russian Federation, IvanovoReferences
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