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Post a Comment Tuberculosis infection in children with negative reactions to the diaskintest
- Authors: Yarovaya Y.A.1, Lozovskaya M.E.1, Klochkova L.V.1, Vasilieva E.B.1, Stepanov G.A.1, Mosina A.V.2
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Affiliations:
- St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
- City Children’s Infectious Hospital No.
- Issue: Vol 10, No 3 (2019)
- Pages: 37-44
- Section: Original studies
- URL: https://journals.rcsi.science/pediatr/article/view/15679
- DOI: https://doi.org/10.17816/PED10337-44
- ID: 15679
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Abstract
Variants of the course of tuberculosis infection in 54 children from two to 14 years old, negatively reacting to a sample with an allergen tuberculosis recombinant (Diaskintest) were analyzed. There were 3 groups: 1st – 27 children infected with Mycobacterium tuberculosis (MBT), 50. 0% of cases; 2nd – 16 children with newly diagnosed residual post-tuberculosis changes (OPTI), 29. 6% of cases; 3rd group – 11 patients with active tuberculosis, 20. 4% of cases.
Methods of examination: intradermal Mantoux test with 2TE and Diaskintest, according to the testimony of a number of patients in vitro tests: QuantiFERON test (QFT), – SPOT test.TV, multispiral computed tomography, bacteriological, molecular genetic methods of investigation on MBT. The method of mass tuberculin diagnostics revealed 70. 4 ± 8. 8% of children of the 1st group, 93. 8 ± 4. 7% of the 2nd group and 54. 6 ± 15. 0% of children of the 3rd group. The duration of infection with MBT in children was different and was less than 1 year in children of the 1st and 2nd groups – 51. 9 ± 9. 6% and 43. 8 ± 12. 4% of cases, respectively, which was significantly more frequent than in patients of the 3rd group (18. 2 ± 11. 6% of cases). Tuberculosis disease occurred in the form of complicated forms of the primary period-in 45. 5 ± 15. 0 % of cases, uncomplicated forms – in 27. 3 ± 3. 4% of cases, generalized lesions – in 27. 3 ± 13. 4% of cases. Diagnosis of a specific lesion occurred equally in the manifest phases of inflammation: infiltration, infiltration and decay (45. 5 ± 15. 0% of cases), and in the phase of ongoing reverse development (incomplete calcination – in 45. 5 ± 15. 0% of cases), one child had a combination of infiltration and calcination phases (9. 1 ± 8. 7% of cases). Residual posttuberculosis changes in children of group 2 were more often formed in the form of calcifications in the organs of the thoracic cavity – in 87. 5% of cases, in 12. 5 ± 8. 3% of patients OPTI was formed by the formation of seals.
Conclusion: in children with negative reactions to the Diaskintest requires individual comprehensive diagnosis of tuberculosis infection.
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##article.viewOnOriginalSite##About the authors
Yulia A. Yarovaya
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: Julia_Yarovaya@mail.ru
MD, PhD, Associate Professor, Department of TB
Russian Federation, Saint PetersburgMarina E. Lozovskaya
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: lozovskaja-marina@rambler.ru
MD, PhD, Dr Med Sci, Professor, Department of TB
Russian Federation, Saint PetersburgLudmila V. Klochkova
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: lklochkova@yahoo.com
MD, PhD, Associate Professor, Department of TB
Russian Federation, Saint PetersburgElena B. Vasilieva
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: Helenchern27@mail.ru
MD, PhD, Associate Professor, Department of TB
Russian Federation, Saint PetersburgGennadii A. Stepanov
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: gena.stepanov.1950@mail.ru
MD, PhD, Associate Professor, Department of TB
Russian Federation, Saint PetersburgAnna V. Mosina
City Children’s Infectious Hospital No.
Email: Julia_Jarovaya@mail.ru
Doctor, Tuberculosis Department
Russian Federation, Saint PetersburgReferences
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