Aspiration lipoid pneumonia in a child 1.5 years

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Abstract

Aspirated lipoid pneumonia is a rare lung disease, in which interstitial lesion with chronic respiratory failure is predominantly expressed. In the available literature, this pathology is described in the form of separate observations with an empirical selection of therapeutic measures. The appearance of lipophages in a bronchial aspirate is recognized as a pathognomonic sign of lipoid pneumonia. There is no etiological treatment of the disease. The effectiveness of intensive therapy, according to available sources, depends on the severity of respiratory failure and on the timing of the start of complex bronchodrainage therapy, and theoretically the most attractive is kinesitherapy. Only one observation describes the use of bronchial lavage with sequential separate intubation of the main bronchi. Hormone therapy is considered effective, but the physiological basis for its use is not presented. The published observation is characterized by a late start of treatment due to a long diagnostic search. The applied therapeutic measures are given and described in detail with an assessment of the expected and achieved practical benefits. It was shown that beneficial effects were due to the use of bronchodrainage therapy techniques, including the jet high-frequency artificial ventilation of the lungs. There are doubts about the appropriateness of the use of corticosteroids in this pathology.

About the authors

Kristina V. Budarova

City Children’s Clinical Emergency Hospital; Novosibirsk State Medical University Hospital

Author for correspondence.
Email: bcv@yandex.ru

Anesthesiologist, Intensive Care Unit; MD, PhD, Associate Professor, Department of Anesthesiology and Intensive Care, Faculty of Medicine

Russian Federation, Novosibirsk

Aleksey N. Shmakov

Novosibirsk State Medical University Hospital

Email: alsmakodav@yandex.ru

MD, PhD, Dr Med Sci, Professor, Department of Anesthesiology and Intensive Care

Russian Federation, Novosibirsk

Vladimir A. Bokut

City Children’s Clinical Emergency Hospital

Email: ORIT2231420@mail.ru

Head of Intensive Care Unit, Anesthesiologist, Intensive Care Unit

Russian Federation, Novosibirsk

Diana Yu. Makarova

City Children’s Clinical Emergency Hospital

Email: ORIT2231420@mail.ru

Anesthesiologist, Intensive Care Unit

Russian Federation, Novosibirsk

Mariya A. Polonskaya

City Children’s Clinical Emergency Hospital

Email: ORIT2231420@mail.ru

Anesthesiologist, Intensive Care Unit

Russian Federation, Novosibirsk

Svetlana V. Uspenskaya

City Children’s Clinical Emergency Hospital

Email: ORIT2231420@mail.ru

Anesthesiologist, Intensive Care Unit

Russian Federation, Novosibirsk

References

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  4. Sias SM, Ferreira AS, Daltro PA, et al. Evolution of exogenous lipoid pneumonia in children: clinical aspects, radiological aspects and the role of bronchoalveolar lavage. J Bras Pneumol. 2009;35(9):839-845. doi: 10.1590/s1806-37132009000900004.
  5. Tukaram SJ, Sastry SDS, Mehta RM. Bronchoscopic Segmental Lavage for Refractory Lipoid Pneumonia in a Toddler. J Bronchology Interv Pulmonol. 2018;25(2): e19-e21. doi: 10.1097/LBR.0000000000000436.
  6. Stathis G, Priftis KN, Moustaki M, Alexopoulou E. Non-resolving Findings in a Long-term Radiographic Follow-up of an Infant with Acute Paraffin Oil Aspiration. J Clin Imaging Sci. 2014;4:2. doi: 10.4103/2156-7514.126028.

Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. CT scan of the chest (3 weeks after the onset of the disease) (a). Signs of diffuse interstitial lung disease, probably bilateral lipoid pneumonia, differential diagnosis with alveolar proteinosis (b)

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3. Fig. 2. CT of the chest organs (5 weeks after the onset of the disease) (a). Signs of diffuse interstitial lung disease. Negative dynamics in the form of increased consolidation in the peripheral parts of the lungs (b)

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4. Fig. 3. CT of the chest organs (8 weeks after the onset of the disease) (a). CT-signs of parenchymal lesion of the lung tissue are preserved, positive dynamics in the form of a decrease in the density of pulmonary consolidation are noted (b)

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5. Fig. 4. CT of the chest organs (11 weeks after the onset of the disease) (a). CT signs of a predominantly basal parenchymal lesion of the lung tissue, the appearance of effusion in the right pleural cavity (b)

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6. Fig. 5. CT of the chest organs (4 months after the onset of the disease) (a).  CT signs of diffuse subtotal lesion of the lung tissue with areas of consolidation in the basal sections S2, S6, S10 on the right and S6 on the left, probably of an inflammatory nature (b)

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7. Fig. 6. CT of the chest organs (5 months after the onset of the disease) (a). CT signs of interstitial damage to the lung tissue with an increase in the area of consolidation in the medial sections of both lungs, while maintaining in the basal sections S2, S6, S10 on the right and S6 on the left (b)

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8. Fig. 7. Photo of patient S., age 1 year 8 months. The recovery stage is the restoration of the ability of independent breathing through a tracheostomy cannula, and a decrease in oxygen dependence

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Copyright (c) 2020 Budarova K.V., Shmakov A.N., Bokut V.A., Makarova D.Y., Polonskaya M.A., Uspenskaya S.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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