Email this article 
Post a Comment The treatment of children infected with COVID-19 in a non-core hospital
- Authors: Ivanov D.O.1, Zabolotskii D.V.1, Koriachkin V.A.1, Alexandrovich Y.S.1, Kopylov V.V.2, Puzyrev V.G.1, Nabieva A.S.1, Bondarenko V.V.1, Bannova S.L.1, Ustinova A.S.2, Pogorelchuk V.V.1
-
Affiliations:
- St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
- K.A. Raukhfus Children’s City Versatile Clinical Center of High Medical Technologies
- Issue: Vol 11, No 2 (2020)
- Pages: 5-14
- Section: Editorial
- URL: https://journals.rcsi.science/pediatr/article/view/120339
- DOI: https://doi.org/10.17816/PED1125-14
- ID: 120339
Cite item
Abstract
According to the World Health Organization (WHO), viral diseases form serious public health problem. WHO announced that the disease caused by the new virus named “coronavirus disease 2019” or “Coronavirus disease 2019” (COVID-19), and the virus causing the infection was named SARS-Cov-2 by the International Committee on Taxonomy of Viruses. Children usually have asymptomatic or mild forms. However, children with comorbidity are in risk of developing severe forms of COVID-19. The review presents modern ideas about the amount of laboratory tests in cases of suspected presence of the SARS-CoV-2 virus, methods of radio diagnostic (computer tomography, x-ray, thorax ultrasound), features of the clinical course of infection in children depending on the severity of the of infection and indicated detailed criteria for severe forms of coronavirus infection. Special attention is focused on the clinical monitoring of children in a non-core hospital: the detection of leukopenia and lymphopenia, CRP level control, monitoring of coagulation disorders, providing tests on other respiratory viruses. Specific recommendations, comprehensive to date, on the use of drugs for the treatment of children with COVID-19 upon admission to a non-core hospital are given. The organisational issues of treatment children infected with COVID-19 in a non-core hospital are described in details. Special attention is focused on the compliance of strict safety rules by staff working with infected patients entering and leaving the “Red” zone. Thus, the proper organisation of the units for the treatment of children infected with COVID-19 in a non-core hospital, taking into account the features of their disease, will make it possible to provide complete and high-quality treatment of infection during the pandemic.
Full Text
##article.viewOnOriginalSite##About the authors
Dmitry O. Ivanov
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: doivanov@yandex.ru
MD, PhD, Dr Med Sci, Professor, Rector
Russian Federation, Saint PetersburgDmitry V. Zabolotskii
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: zdv4330303@gmail.com
MD, PhD, Dr Med Sci, Professor, Head, Prof. V.I. Gordeev Department of Anesthesiology, Resuscitation and Emergency Paediatrics
Russian Federation, Saint PetersburgVictor A. Koriachkin
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: vakoryachkin@mail.ru
MD, PhD, Dr Med Sci, Professor, Prof. V.I. Gordeev Department of Anesthesiology, Resuscitation and Emergency Paediatrics
Russian Federation, Saint PetersburgYury S. Alexandrovich
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: jalex1963@mail.com
MD, PhD, Dr Med Sci, Prof., Head, Department of Anaesthesiology, Resuscitation and Emergency Paediatrics of the FP and AdE
Russian Federation, Saint PetersburgVladimir V. Kopylov
K.A. Raukhfus Children’s City Versatile Clinical Center of High Medical Technologies
Email: kovlad@mail.ru
MD, PhD, Head, Department of Anesthesiology and Resuscitation
Russian Federation, Saint PetersburgViktor G. Puzyrev
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: vgpuzyrev@mail.ru
MD, PhD, Assistant Professor, Head, Department of General Hygiene
Russian Federation, Saint PetersburgAnna S. Nabieva
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: hamatum@bk.ru
Epidemiologist of the Clinic, Assistant, Department of General Hygiene
Russian Federation, Saint PetersburgValeria V. Bondarenko
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: bondarenkovaleriya@list.ru
Assistant Epidemiologist of the Clinic, Senior Laboratory Technician, Department of General Hygiene
Russian Federation, Saint PetersburgSvetlana L. Bannova
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: svetlanalb81@mail.ru
MD, PhD, Associate Professor, Prof. M.G. Danilevich Department of Infectious Diseases in Children
Russian Federation, Saint PetersburgAnastasia S. Ustinova
K.A. Raukhfus Children’s City Versatile Clinical Center of High Medical Technologies
Email: kovlad@mail.ru
Doctor, Department of Anesthesiology and Resuscitation
Russian Federation, Saint PetersburgViktor V. Pogorelchuk
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: viktor-pogorelchuk@yandex.ru
MD, PhD, Associate Professor, Prof. V.I. Gordeev Department of Anesthesiology, Resuscitation and Emergency Paediatrics
Russian Federation, Saint PetersburgReferences
- Временные методические рекомендации «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Версия 5 (08.04.2020)». Министерство здравоохранения Российской Федерации. Москва, 2020. 122 с. [Vremennyye metodicheskiye rekomendatsii “Profilaktika, diagnostika i lecheniye novoy koronavirusnoy infektsii (COVID-19). Versiya 5 (08.04.2020)”. Ministerstvo zdravookhraneniya Rossiyskoy Federatsii. Moskva, 2020. 122 s. (In Russ.)]
- СОVID-19 у детей. Временные методические рекомендации (версия 1) от 03.04.2020. – Москва, 2020. – 68 с. [Metodicheskiye rekomendatsii. Osobennosti klinicheskikh proyavleniy i lecheniya zabolevaniy, vyzvannykh novoy koronavirusnoy infektsiyey (COVID-19) u detey. Versiya 1 (24.04.2020). Moskva, 2020. – 68 s. (In Russ.)]
- Методические рекомендации. Особенности клинических проявлений и лечения заболевания, вызванного новой коронавирусной инфекцией (COVID-19) у детей. Версия 1 (24.04.2020). – Москва, 2020. – 44 с. [Metodicheskiye rekomendatsii. Osobennosti klinicheskikh proyavleniy i lecheniya zabolevaniy, vyzvannykh novoy koronavirusnoy infektsiyey (COVID-19) u detey. Versiya 1 (24.04.2020). Moskva, 2020. – 44 s. (In Russ.)]. Доступно: https://www.24042020_child_COVID-19_1_Final.pdf%20(1).pdf.
- Сборник методических рекомендаций, алгоритмов действий медицинских работников на различных этапах оказания помощи, чек-листов и типовых документов, разработанных на период наличия и угрозы дальнейшего распространения новой коронавирусной инфекции в Санкт-Петербурге. Версия 1,0 от 17.04.2020. – Санкт-Петербург, 2020. – 157 с. [Sbornik metodologicheskikh rekomendatsiy, algoritmov deystviy meditsinskikh rabotnikov na razlichnykh etapakh okazaniya pomoshchi, chek-listy i tipovyye dokumenty, razrabotchiki s tsel’yu obespecheniya i rasprostraneniya novykh koronavirusnykh infektsiy v Sankt-Peterburge. Versiya 1.0 ot 17.04.2020. Sankt-Peterburg 2020 g. – 157 s. (In Russ.)]
- Brodin P. Why is COVID-19 so mild in children? [published online ahead of print, 2020 Mar 25]. Acta Paediatr. 2020;10.1111/apa.15271. doi: 10.1111/apa.15271.
- Cascella M, Rajnik M, Cuomo A, et al. Features, Evaluation and Treatment Coronavirus (COVID-19). [Updated 2020 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554776/
- Coronavirus Disease 2019 in Children – United States, February 12-April 2, 2020. Weekly. 2020;69(14)
- Dong Y, Mo X, Hu Y, et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics. 2020;145(5):e20200702. https://doi.org/10.1542/peds.2020-0702.
- Kelvin Kai-Wang To, Owen Tak-Yin Tsang, Wai-Shing Leung, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. The Lancet. 2020;5:565-574. https://doi.org/10.1016/S1473-3099(20)30196-1.
- Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382:1663-1665. doi: 10.1056/nejmc2005073.
- Ong SWX, Tan YK, Chia PY et al. Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient. JAMA. 2020;323(16):1610-1612. doi: 10.1001/jama.2020.3227.
- Sun D, Li H, Lu X, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr. 2020 Mar 19. https://doi.org/10.1007/s12519-020-00354-4.
- Wenjie Tan, Xiang Zhao, Xuejun Ma, at al. Notes from the Field: A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases – Wuhan, China 2019–2020. China CDC Weekly. 2020;2(4):61-62.
- Ke Wang, Wei Chen, Yu-Sen Zhou, et al. SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. BioRxiv preprint. 2020 https://doi.org/10.1101/2020.03.14.988345.
- Ulrich H., Pillat M.M. CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement. Stem Cell Rev Rep. 2020 Apr 20. https://doi.org/10.1007/s12015-020-09976-7.
- Wei M, Yuan J, Liu Y, et al. Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China. JAMA. 2020;323(13):1313-1314. doi: 10.1001/jama.2020.2131.
- World Health Organization. Report of the WHO-China joint mission on COVID-19, 16-24 February 2020. Geneva (Switzerland): World Health Organization; 2020.
- Xu, Y., Li, X., Zhu, B. et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502-505. https://doi.org/10.1038/s41591-020-0817-4.
- Zheng F, Liao C, Fan QH, at al. Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China. Curr Med Sci. 2020;40:275-280. https://doi.org/10.1007/s11596-020-2172-6.
