Clinical case of a Erythroderma induced by fibrogastroduodenoscopy

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Abstract

Erythroderma – the term used for the description intensive and usually widespread reddening of the skin which has arisen owing to activation of the previous inflammatory dermatosis. Among the causes of erythroderma are the progression of chronic dermatoses, refractory to therapy, medication or inadequate local treatment of dermatoses. In addition, it can be a symptom and/or a sign of systemic diseases (lymphoma, leukemia, tumors of the lungs, intestines and ovaries). Most of the cases of erythroderma described in the literature were induced by taking different types of drugs and dietary supplements. High lethality of this category of patients is associated with both the main disease that caused the development of erythroderma and the nature of emerging metabolic disorders. Erythroderma is one of the most severe conditions that threaten the life of the patient, requiring special approaches in the diagnosis and early treatment. When diagnosing and determining the forms of erythroderma, one of the determining factors is clinical examination and clinical and pathological correlation. Patients with diseases of a digestive tract have high risk of development of side effects from intake of drugs and carrying out tool methods of a research. One of the screening methods of a research is the fibrogastroduodenoskopy (EGD). We provide the description of the first case in our practice of the patient with the erythroderma which has arisen after the EGD-research. Questions of pathogenesis, differential diagnostics of an erythroderma on the basis of a clinical picture and histological signs with illustrations are also discussed.

About the authors

Akmal A. Sidikov

St. Petersburg State Pediatric Medical University

Author for correspondence.
Email: medik-85@bk.ru

MD, PhD, Assistant, Department of Pathological Anatomy with a Course of Forensic Medicine

Russian Federation, Saint Petersburg

Denis V. Zaslavsky

St. Petersburg State Pediatric Medical University

Email: venerology@gmail.com

MD, PhD, D.Sc., Professor, Dermatovenereology Department

Russian Federation, Saint Petersburg

Yuliya S. Egorova

St. Petersburg State Pediatric Medical University

Email: ys-egorova@mail.ru

MD, PhD, Associate Professor of Dermatovenereology Department

Russian Federation, Saint Petersburg

Igor N. Chuprov

North-Western State Medical University named after I.I. Mechnikov

Email: igorchuprov@gmail.com

MD, PhD, D.Sc., Associate Professor, Department of Pathological Anatomy

Russian Federation, Saint Petersburg

Yanina Yu. Gurkovskaya

Leningrad Regional Center of Specialized Types of Medical Care

Email: yaninagurkovskay@gmail.com

MD, Doctor

Russian Federation, Saint Petersburg

Marina N. Fomenko

Leningrad Regional Center of Specialized Types of Medical Care

Email: m.fomenko2009@yandex.ru

MD, Doctor

Russian Federation, Saint Petersburg

Michail A. Zubatov

St. Petersburg State Pediatric Medical University

Email: zubatov@mail.ru

Sixth-Year Student

Russian Federation, Saint Petersburg

Ruslan A. Nasyrov

St. Petersburg State Pediatric Medical University

Email: ran.53@mail.ru

MD, PhD, Professor, Head, Department of Pathological Anatomy with a Course in Forensic Medicine

Russian Federation, Saint Petersburg

Ekaterina V. Grekova

I.M. Sechenov First Moscow State Medical University

Email: grekova_kate@mail.ru

Graduate Student, V.A. Rakhmanov Department of Skin and Veneral Diseases

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. Patient, 63 years old, the diagnosis – an erythroderma. The patient’s skin throughout was brightly red color with a cyanotic shade, considerably an infiltrated, with signs of scaling

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3. Fig. 2. The same patient. Histologic picture, the diagnosis – an erythroderma. In epidermis parakeratosis, irregular acanthosis, single apototic cells in suprabasal and granular layers are noted. In derma there are perivascular lymphocytic infltrates with a tenedention to penetration into epidermis (exocytosis). Colouring hematoxylin and eosin. Increase ×100

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4. Fig. 3. The same patient. In 2 weeks from an initiation of treatment, skin it was cleaned from specific rashes

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Copyright (c) 2018 Sidikov A.A., Zaslavsky D.V., Egorova Y.S., Chuprov I.N., Gurkovskaya Y.Y., Fomenko M.N., Zubatov M.A., Nasyrov R.A., Grekova E.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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