Visualization capabilities of experimental oncological models in small laboratory animals
- Authors: Pechatnikova V.A.1, Trashkov A.P.1, Zelenenko M.A.2, Verlov N.A.1, Chizh G.A.1, Khotin M.G.3, Vasiliev A.G.4
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Affiliations:
- Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre “Kurchatov Institute”
- Sechenov Institute of Ephysiology and Biochemistry, Russian Academy of Sciences
- Institute of Cytology RAS
- St. Petersburg State Pediatric Medical University
- Issue: Vol 9, No 4 (2018)
- Pages: 105-112
- Section: Articles
- URL: https://journals.rcsi.science/pediatr/article/view/10410
- DOI: https://doi.org/10.17816/PED94105-112
- ID: 10410
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Abstract
For a long time non-invasive imaging methods have been inaccessible in preclinical practice; their introduction lately has broadened the boundaries of relevant studies and felicitated new approaches to solving fundamental problems. Up-to-date imaging methods constitute an essential component of preclinical and translational biomedical research allowing quick and non-invasive extended representation of structural organization and functional characteristics of pathological processes in vivo. Methods of radiation diagnosis and nuclear magnetic resonance allow to assess the state of bones, soft tissues, internal organs, blood vessels and peripheral nerve fibers in various animals, not only mammals, but also fish, amphibians, reptiles and insects. Multiparametric studies can uniquely localize any anatomical structure or pathological process. However, not all existing techniques are applicable to various oncological models of small laboratory animals.
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##article.viewOnOriginalSite##About the authors
Valeria A. Pechatnikova
Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre “Kurchatov Institute”
Author for correspondence.
Email: floluttrell@gmail.com
Researcher, Trials Center of Radiopharmaceutical
Russian Federation, GatchinaAlexander P. Trashkov
Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre “Kurchatov Institute”
Email: alexandr.trashkov@gmail.com
MD, PhD, Head, Trials Center of Radiopharmaceutical
Russian Federation, GatchinaMaria A. Zelenenko
Sechenov Institute of Ephysiology and Biochemistry, Russian Academy of Sciences
Email: magu56110@gmail.com
MD, Researcher, Experimental Pharmacology Department
Russian Federation, Saint PetersburgNikolay A. Verlov
Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre “Kurchatov Institute”
Email: virlov@gmail.com
PhD, Senior researcher, Trials Center of Radiopharmaceutical
Russian Federation, GatchinaGrigorii A. Chizh
Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre “Kurchatov Institute”
Email: ya.grisha234@yandex.ru
Junior Researcher, Molecular and Radiation Biophysics Division
Russian Federation, GatchinaMichael G. Khotin
Institute of Cytology RAS
Email: h_mg@mail.ru
PhD, Associate Professor, Head, Cell Technology Center
Russian Federation, Saint PetersburgAndrei G. Vasiliev
St. Petersburg State Pediatric Medical University
Email: avas7@mail.ru
MD, PhD, Dr. Med. Sci., Head, Pathophysiology Department
Russian Federation, Saint PetersburgReferences
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