Vascularization of chorion villi in the first trimester of gestation with physiological course and in recurrent miscarriage with underlying chronic endometritis

Aim. To study stages of vasculo- and angiogenesis in uncomplicated course of the first trimester of gestation and to identify disorders in vascularization of the villous chorion in recurrent miscarriages and chronic endometritis.

Materials and Methods. The main group – villous chorion of 5-12 weeks of gestation obtained from female patients with recurrent miscarriage and chronic endometritis (n=35); comparison group – villous chorion obtained from clinically healthy females in official abortions (n=30). On the basis of the results of morphological examination the analysis of stages of vascularization of villous chorion was carried out.

Results. In recurrent miscarriage associated with chronic inflammation of the endometrium, structural changes of the villous chorion were detected manifested by retardation of differentiation of villi starting from the 5th week of gestation, by delay of vasculogenesis at the stage of formation of hemangioblastic cords typical of the 6-7th week with its inhibition in the subsequent periods. In villi of the 8-12th weeks of gestation no further differentiation of vessels was seen, hence, branched angiogenesis did not form.

Conclusion. Disorders in differentiation of villi, in vasculo- and angiogenesis in the stroma of chorion villi with the underlying chronic inflammation of the endometrium that produced negative effect on further development and successful completion of gestation, were proved.