生物类黄酮治疗下肢继发性淋巴水肿的临床疗效

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目的：研究结合使用微粉化的纯化黄酮类药物（MPFF）和弹性压缩治疗获得性淋巴郁积患者的有效性。

材料与方法。根据M. Foeldi，该研究包括60例下肢II期继发性淋巴水肿患者。采用包络法随机化，将患者分为两组。第一组（n=30）采用保守治疗（MPFF，1000 mg/d）联合弹性压缩治疗（三级弹力袜）；第二组（n=30）仅接受压迫治疗（三级弹力袜）。患者接受体检，包括测量不同水平的肢体周长。

结果。在第一组患者中，小腿下三分之一的周长在1个月后下降了8.15% （p=0.005），到治疗结束时下降了10.6%（p<0.001），小腿中间三分之一处分别下降了3.15%（p=0.001）和4.78%（p<0.001），小腿上部三分之一处分别下降了4.08%（p<0.001）和5.99%（p<0.001）。随访结束时（3个月），第二组下三分之一组小腿周长（29.68±4.67cm）明显长于第一组（26.65±2.92cm，p=0.035）。MPFF组未发生不良反应。

结论。与单独使用弹性压缩相比，MPFF和弹性压缩联合使用可在更大程度上减少获得性淋巴水肿患者的下肢体积。MPFF治疗下肢继发性淋巴水肿疗效显著，且无不良反应，值得推荐在药物治疗方案中使用。

作者简介

Roman Kalinin

Ryazan State Medical University

Email: kalinin-re@yandex.ru
ORCID iD: 0000-0002-0817-9573
SPIN 代码: 5009-2318
Scopus 作者 ID: 24331764400
Researcher ID: M-1554-2016

MD, Dr.Sci.(Med.), Professor, Head of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy

俄罗斯联邦, Ryazan

Igor Suchkov

Ryazan State Medical University

Email: suchkov_med@mail.ru
ORCID iD: 0000-0002-1292-5452
SPIN 代码: 6473-8662
Scopus 作者 ID: 56001271800
Researcher ID: M-1180-2016

MD, Dr.Sci.(Med.), Professor, Professor of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy

俄罗斯联邦, Ryazan

Denis Maksaev

Ryazan State Medical University

编辑信件的主要联系方式.
Email: denma1804@yandex.ru
ORCID iD: 0000-0003-3299-8832
SPIN 代码: 9962-2923
Researcher ID: AAH-3461-2021

PhD-student of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy

俄罗斯联邦, Ryazan

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