电邮这篇文章 肾干细胞在超侵入后睾吸虫病中的增殖活性和分化（实验研究）
- 作者: Uruzbaev R.1,2, Bychkov V.1, Vikhareva L.1, Molokova O.1
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隶属关系:
- Tyumen State Medical University
- Multipurpose Clinical Medical Center «Medical City»
- 期: 卷 29, 编号 2 (2021)
- 页面: 213-218
- 栏目: Original study
- URL: https://journals.rcsi.science/pavlovj/article/view/57046
- DOI: https://doi.org/10.17816/PAVLOVJ57046
- ID: 57046
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详细
目的：在实验动物中鉴定肾脏在不同形式的后睾吸虫病中复制潜能的反应。
材料与方法。实验对象为60只叙利亚雄性仓鼠。第Ⅰ组（n=10）为对照组，第II组（n=25）为染有Opisthorchis felineus后期囊幼虫的动物，第III组包括（n=25）动物，超侵入型蛲虫模型：被50只O. felineus幼虫感染的动物，14和25天后再被50只囊蚴感染。通过过量麻醉将仓鼠从实验中取出，并将其斩首，实验持续7、15、30天。分离肾脏并进行组织学检查，包括使用组织化学和免疫组化染色方法。然后显微镜检查，并对结果进行统计分析。
结果。揭示了局部干细胞的数量特征、增殖趋势和分化。肾皮质和髓质中检测到CD117、Oct4、CD34和CD31阳性干细胞标记物的表达。这些标记物进一步分化为祖细胞，形成小管状的上皮结构。肾小球可见血管生成，血管袢增加。
结论。具有分泌物的O. felineus启动肾小管干细胞和微循环床周细胞的活化。骨盆和输尿管起始部分有明显的移行上皮增生。此外，在寄生虫分泌组的影响下，肾小球袢中有明显的干细胞增殖。
关键词
作者简介
Rinat Uruzbaev
Tyumen State Medical University; Multipurpose Clinical Medical Center «Medical City»
编辑信件的主要联系方式.
Email: uruzbaevrm@mail.ru
ORCID iD: 0000-0001-6883-0543
MD, Cand.Sci.(Med.), Associate Professor of the Pathological Anatomy and Forensic Medicine Department
俄罗斯联邦, Tyumen; TyumenVitaly Bychkov
Tyumen State Medical University
Email: uruzbaevrm@mail.ru
ORCID iD: 0000-0002-0211-2669
MD, Dr.Sci.(Med.), Profеssor, Profеssor of thе Pathological Anatomy and Forensic Medicine Department
俄罗斯联邦, TyumenLarisa Vikhareva
Tyumen State Medical University
Email: vihareva@tyumsmu.ru
ORCID iD: 0000-0001-6864-4417
MD, Dr.Sci.(Med.), Profеssor, Head of the Human Anatomy, Topographic Anatomy and Operative Surgery Department
俄罗斯联邦, TyumenOlga Molokova
Tyumen State Medical University
Email: molokova_tyumsmu@mail.ru
ORCID iD: 0000-0002-3736-3089
MD, Dr.Sci.(Med.), Associate Professor, Professor of the Pathological Anatomy and Forensic Medicine Department
俄罗斯联邦, Tyumen参考
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