电邮这篇文章 EFFECT OF THE DEGREE OF IMMUNOSUPPRESSION AND HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON SERUM IL-17 AND IL-10 LEVEL IN PATIENTS WITH HIV-INFECTION
- 期: 卷 21, 编号 3 (2013)
- 页面: 65-69
- 栏目: Articles
- URL: https://journals.rcsi.science/pavlovj/article/view/4766
- DOI: https://doi.org/10.17816/PAVLOVJ2013365-69
- ID: 4766
如何引用文章
全文:
详细
We analyzed IL-17 and IL-10 serum levels in HIV-infected patients with different stage of disease, degree of immunodeficiency and treatment. We observed 70 patients with HIV infection. Among the patients studied 44 patients on antiretroviral therapy. HIV infection is marked increase in the concentration of IL-10, especially in patients with severe immunosuppression (CD4 <200 ml-1). In HIV-infected patients with severe immunosuppression, which do not receive highly active antiretroviral therapy, there is an increase of IL-10 and IL-17 in serum, which may indicate a systemic immune activation.
关键词
参考
- Cytokine profile in human immunodeficiency virus positive patients with and without tuberculosis / S.K. Agarwal [et al.] // J. Assoc. Physicians. India. – 2001. – Vol. 49. – P. 799-802.
- Breen E.C. Pro- and anti-inflammatory cytokines in human immunodeficiency virus infection and acquired immunodeficiency syndrome / E.C. Breen // Pharmacol. Ther. – 2002. – Vol. 95. – P. 295-304.
- CD4 T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism / D.R. Chung [et al.] // J. Immunol. 2003. – Vol. 170. – P. 1958-1963.
- Roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection / K.I. Happel [et al.] // J. Immunol. – 2003. – Vol. 170. – P. 4432-4436.
- Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways / M. Miyamoto [et al.] // J. Immunol. – 2003. – Vol. 170. – P. 4465-4472.
- Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid / D. Mucida [et al.] // Science. – 2007. – Vol. 317. – P. 256-260.
- Intracellular production of type I and type II cytokines during HIV-1 progression in Thai patients / N. Onlamoon [et al.] // Asian. Pac. J. Allergy. Immunol. – 2003. – Vol. 21. – P. 43-48.
- Interleukin-17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice / E. Tartour [et al.] // Cancer. Res. – 1999. – Vol. 59. – P. 3698-3704.
- TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing ROR gammat function / L. Zhou [et al.] // Nature. – 2008. – Vol. 453. – P. 236-240.
