电邮这篇文章 慢性胰腺炎复杂临床表现的早期诊断和预测的可能性
- 作者: Tarasenko S.1, Natalskiy A.1, Peskov O.1, Bogomolov A.1, Nikiforov A.1, Avilushkina E.1, Tarakanov P.1
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隶属关系:
- Ryazan State Medical University
- 期: 卷 29, 编号 2 (2021)
- 页面: 267-276
- 栏目: Original study
- URL: https://journals.rcsi.science/pavlovj/article/view/34887
- DOI: https://doi.org/10.17816/PAVLOVJ34887
- ID: 34887
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详细
目的：改进方法诊断复杂的临床评估形式的慢性胰腺炎的临床意义的阳离子胰蛋白酶原的基因多态性（PRSS1），胰腺分泌的胰蛋白酶抑制剂（SPINK1），囊性纤维化跨膜调节器 （CFTR），酒精脱氢酶在复杂型（ADH）和非复杂型慢性胰腺炎患者中的作用。
材料与方法：该研究于2014-2019年在以Ryazan State Medical University named after academician I.P. Pavlov的梁赞国立医科大学医院外科临床基地进行，梁赞肝脏、胰腺和胆道外科中心。我们检查了108例25至65岁的男女患者，其中38例手术治疗合并CP，20例未手术治疗合并慢性胰腺炎，50例无合并慢性胰腺炎（对照组）。与对照组患者进行临床比较研究，在第1天和第10天同时测定基因型，并监测实验室参数。使用“DNA-表达-血液”试剂从全血白细胞中分离DNA进行分析（Lytech有限责任公司，俄罗斯）。
结果：阳离子胰蛋白酶原PRSS1基因和囊性纤维化-2基因CFTR2未发现多态性，这些多态性的预测价值不显著。对于CFTR1囊性纤维化-1基因多态性，比值比为0.444，但无统计学意义。患者复杂临床形式的慢性胰腺炎，阳离子胰蛋白酶原基因的突变PRSS1（χ2=6.453，p=0.012）和抗利尿激素（χ2=14.176，p=0.001）经常被记录，而对于CFTR-1基因χ2=0.873（p=0.351），雌性生殖道- 2χ2不确定，SPINK1—体内χ2=0.873（p=0.351）。研究表明，ADH和正离子胰蛋白酶原PRSS1基因的多态性对应胰腺实质和导管系统更明显的结构变化，导致并发症的可能性更大，病程严重，保守治疗的效率较低；ADH基因多态性增加了囊性CP的发生风险（χ2=5.898，p=0.016）。
结论：在慢性胰腺炎的复杂诊断中，当确定慢性胰腺炎患者的手术治疗指征时，推荐使用ADH基因和阳离子胰蛋白酶原多态性的检测。
作者简介
Sergey Tarasenko
Ryazan State Medical University
Email: lorey1983@mail.ru
ORCID iD: 0000-0002-0032-6831
SPIN 代码: 7926-0049
Researcher ID: S-6744-2016
MD, Dr.Sci.(Med.), Professor, Head of the Department of Hospital Surgery
俄罗斯联邦, RyazanAlexander Natalskiy
Ryazan State Medical University
编辑信件的主要联系方式.
Email: lorey1983@mail.ru
ORCID iD: 0000-0002-2387-3440
SPIN 代码: 6503-4327
Researcher ID: N-4944-2016
MD, Dr.Sci.(Med.), Associate Professor, Professor of the Department of Hospital Surgery
俄罗斯联邦, RyazanOleg Peskov
Ryazan State Medical University
Email: lorey1983@mail.ru
ORCID iD: 0000-0003-4467-3461
SPIN 代码: 4539-9830
Researcher ID: W-4123-2017
MD, Cand.Sci.(Med.), Associate Professor, Associate Professor of the Department of Hospital Surgery
俄罗斯联邦, RyazanAleksey Bogomolov
Ryazan State Medical University
Email: alexej.rzgmu@gmail.com
ORCID iD: 0000-0001-8095-3968
SPIN 代码: 1846-7047
Researcher ID: AAQ-8645-2020
MD, Cand.Sci.(Med.), Assistant of the Department of Hospital Surgery
俄罗斯联邦, RyazanAleksandr Nikiforov
Ryazan State Medical University
Email: alnik003@yandex.ru
ORCID iD: 0000-0001-9742-4528
SPIN 代码: 8366-5282
Researcher ID: AAQ-9095-2020
MD, Cand.Sci.(Med.), Associate Professor of the Department of Pharmacology with the Course of Pharmacy of the Faculty Additional Professional Education
俄罗斯联邦, RyazanElena Avilushkina
Ryazan State Medical University
Email: elena.avilushkina@gmail.com
ORCID iD: 0000-0002-4742-0796
SPIN 代码: 2989-3190
Researcher ID: AAR-1219-2020
Resident of the Department of Hospital Surgery
俄罗斯联邦, RyazanPavel Tarakanov
Ryazan State Medical University
Email: lorey1983@mail.ru
ORCID iD: 0000-0002-8358-6603
SPIN 代码: 8125-4110
Researcher ID: AAN-9597-2020
Resident of the Department of Hospital Surgery
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