Possibilities of use of plant derived nonstarch polysaccharides in clinical practice

Cover Page

Cite item

Full Text

Abstract

Inhibition of Pglycoprotein transporter protein (ABCB1protein, Pgp) is a promising method to increase the effectiveness of pharmacotherapy in different pathologies: neoplastic diseases, epilepsy, cerebral circulation disorders. Pgp is a large transmembrane protein that provides efflux of a wide range of endo and xenobiotics from cells, and plays a significant role in pharmacokinetics of many medical drugs. Nowadays not a single synthetic inhibitor of the transporter is used in clinical practice due to nonselectivity of action, toxicity and high cost. Medicinal herbal remedies possess different pharmacological and therapeutic effects, rarely cause side effects and are economically accessible. This review presents the results of experiments in which affiliation of the oligo and polysaccharides to substrates and inhibitors of Pgp was analyzed, and which precondition further studies of other plant derived polysaccharides. Possibilities of using plant derived nonstarch polysaccharides in complex therapy of tumors are described, since along with potential inhibition of the transporter, they possess an antitumor effect and can also assist in correction of side effects of cytostatics. The prospects of using plant derived nonstarch polysaccharides for improvement of the effectiveness of neuroprotective therapy are presented, because they not only can increase the penetration of neuroprotective drugs across the bloodbrain barrier through Pgp inhibition, but also possess their own neuroprotective activity, as well as a number of pharmacological effects that can give a positive result in the complex treatment of brain pathologies. Thus investigations of plant nonstarch polysaccharides, their isolation and development of medical drugs on their basis is a promising direction of modern medicine.

About the authors

Ivan V. Chernykh

Ryazan State Medical University

Email: p34-66@yandex.ru
ORCID iD: 0000-0002-5618-7607
SPIN-code: 5238-6165

PhD in Biological sciences, Assistant of the Department of General Chemistry and Pharmachemistry

Russian Federation, 9, Vysokovoltnaja str., Ryazan, 390026

Ekarina E. Kirichenko

Ryazan State Medical University

Email: p34-66@yandex.ru
ORCID iD: 0000-0002-5950-7952
SPIN-code: 1895-6145

PhD in Biological sciences, Assistant of the Department of General Chemistry and Pharmachemistry

Russian Federation, 9, Vysokovoltnaja str., Ryazan, 390026

Aleksey V. Shchulkin

Ryazan State Medical University

Email: p34-66@yandex.ru
ORCID iD: 0000-0003-1688-0017
SPIN-code: 2754-1702

MD, PhD, Assistant Professor of Pharmacology Department with Course of Pharmacy of Continuing Professional Education Faculty

Russian Federation, 9, Vysokovoltnaja str., Ryazan, 390026

Natalia M. Popova

Ryazan State Medical University

Author for correspondence.
Email: p34-66@yandex.ru
ORCID iD: 0000-0002-5166-8372
SPIN-code: 7553-9852

MD, PhD, Senior Teacher of Pharmacology Department with Course of Pharmacy of Continuing Professional Education Faculty

Russian Federation, 9, Vysokovoltnaja str., Ryazan, 390026

Anna A. Kotlyarova

Ryazan State Medical University

Email: p34-66@yandex.ru
ORCID iD: 0000-0002-0676-7558
SPIN-code: 9353-0139

Assistant of Pharmacology Department with Course of Pharmacy of Continuing Professional Education Faculty

Russian Federation, 9, Vysokovoltnaja str., Ryazan, 390026

References

  1. Kukes VG, Grachev SV, Sychev DA, et al. Metabolizm lekarstvennykh sredstv. Nauchnye osnovy personalizovannoy meditsiny: rukovodstvo dlya vrachey. Moscow: GEOTARMedia; 2008. (In Russ).
  2. Liu ZH, Ma YL, He YP, et al. Tamoxifen reverses the multidrugresistance of an established human cholangiocarcinoma cell line in combined chemotherapeutics. Molecular Biology Reports. 2010;14:16977. doi: 10.1007/s110330100291z
  3. Yakusheva EN, Chernykh IV, Shchulkin AV, et al. Pglycoprotein expression in brain during ischemiareperfusion. I.P. Pavlov Russian Medical Biological Herald. 2015;23(4):4450. (In Russ).
  4. Lomovskaya O, Bostian KA. Practical applications and feasibility of efflux pump inhibitors in the clinic – a vision for applied use. Biochemical Pharmacology. 2006;71(7):9108. doi: 10.1016/j.bcp.2005.12.008
  5. Darby RA, Callaghan R, Mcmahon RM. Pglycoprotein inhibition; the past, the present and the future. Current Drug Metabolism. 2011;12(8): 72231. doi: 10.2174/138920011798357006
  6. Pusztai L, Wagner P, Ibrahim N, et al. Phase II study of tariquidar, a selective Pglycoprotein inhibitor, in patients with chemotherapyresistant, advanced breast carcinoma. Cancer. 2005;104(4):68291. doi: 10.1002/cncr.21227
  7. Srivalli KMR, Lakshmi PK. Overview of Pglycoprotein inhibitors: a rational outlook. Brazilian Journal of Pharmaceutical Sciences. 2012;48(3): 35367. doi: 10.1590/S198482502012000300002
  8. Shchulkin AV, Popova NM, Chernykh IV. The original and generic drugs: current state of the problem. Science of Young (Eruditio Juvenium). 2016;2:305. (In Russ).
  9. Engalycheva EE, Yakusheva EN, Sychev IA, et al. Study of hepatoprotective activity of flowers tansy polysaccharide complex I.P. Pavlov Russian Medical Biological Herald. 2015;23(2):505. (In Russ).
  10. Zubov AA. Ispol'zovaniye preparatov iz morskikh vodorosley dlya profilaktiki i lecheniya patologicheskikh sostoyaniy. Ekologiya cheloveka. 1998;3:2731. (In Russ).
  11. Poongavanam V, Haider N, Ecker GF. Fingerprintbased in silico models for the prediction of Pglycoprotein substrates and inhibitors. Bioorganic&Medicinal Chemistry. 2012;20(18): 538895. doi: 10.1016/j.bmc.2012.03.045
  12. Carrigos M, Mir LM, Orlowski S. Competitive and NonCompetitive Inhibition of the MultidrugResistanceAssociated Pglycoprotein ATPase. European Journal of Biochemistry. 1997;244(2): 66473. doi: 10.1124/mol.62.6.1288
  13. Fenivesi F, Fenivesi E, Szente L, et al. Pglycoprotein inhibition by membrane cholesterol modulation. European Journal of Pharmaceutical Science. 2008;34(45):23642. doi:10.1016/ j.ejps.2008.04.005
  14. Cheng JW, Zhang LJ, Hou YQ, et al. Association between MDR1 C3435T polymorphism and refractory epilepsy in the Chinese population: A systematic review and metaanalysis. Epilepsy Behavior. 2014;36:1739. doi:10.1016/ j.yebeh.2014.05.007
  15. Angelini A, Febbo CD, Ciofani G, et al. Inhibition of Pglycoproteinmediated multidrug resistance by unfractionated heparin: a new potential chemosensitizer for cancer therapy. Cancer Biology & Therapy. 2005;4(3):31317. doi: 10.4161/cbt.4.3.1503
  16. CruzMorales S, CastanedaGomez J, RosasRamirez D, et al. Resin Glycosides from Ipomoea alba Seeds as Potential Chemosensitizers in Breast Carcinoma Cells. Journal of Natural Products. 2016;79(12):3093104. doi: 10.1021/acs.jnatprod.6b00782
  17. Slomiany MG, Grass GD, Robertson AD, et al. Hyaluronan, CD44, and Emmprin Regulate Lactate Efflux and Membrane Localization of Monocarboxylate Transporters in Human Breast Carcinoma Cells. Cell, Tumor, and Stem Cell Biology. 2009;69(4):1293301. doi: 10.1158/00085472
  18. Baek JS, Cho CW. 2‐Hydroxypropyl ‐β‐cyclodextrin‐modified SLN of paclitaxel for overcoming P‐glycoprotein function in multidrug‐resistant breast cancer cells. Journal of Pharmacy and Pharmacology. 2013;65(1):728. doi: 10.1111/j.20427158. 2012.01578.x
  19. Kobayashi E, Iyer AK, Hornicek FJ, et al. Lipidfunctionalized Dextran Nanosystems to Overcome Multidrug Resistance in Cancer: A Pilot Study. Clinical Orthopaedics and Related Research. 2013;471(3):91525. doi:10.1007/ s1199901226102
  20. Niu YC, Liu JC, Zhao XM, et al. A low molecular weight polysaccharide isolated from Agaricus Blazei suppresses tumor growth and angiogenesis in vivo. Oncology Reports. 2009; 21(1):14552. doi: 10.3892/or_00000201
  21. Hague A, Elder DJE, Hicks DJ, et al. Apoptosis in colorectal tumorcells. Induction by the shortchain fattyacids butyrate, propionate and acetate and by the bilesalt deoxycholate. International Journal of Cancer. 1995;60:4006. doi: 10.1002/ijc.2910600322
  22. Safonova EA, Guriev AM, Razina TG, et al. Increase of chemotherapy efficiency by means of fractions isolated from polysaccharides complex Acorus Calamus L. Rossiyskiy bioterapevticheskiy zhurnal. 2012;11(4):558. (In Russ).
  23. Iguchi C, Nio Y, Takeda T, et al. Plant polysaccharide PSK: cytostatic effects on growth and invasion; modulating effect on the expression of HLA and adhesion molecules on human gastric and colonic tumor cell surface. Anticancer research. 2001;21:100713.
  24. Lopatina KA, Guryev AM, Razina TG, et al. Influence of polysaccharides from acorus calamus rizomes on functional activity of murine limphnode cells after experimental tumor chemotherapy. Sibirskiy onkologicheskiy zhurnal. 2006;3:5963. (In Russ).
  25. Safonova EA, Razina TG, Zueva EP, et al. Prospects for the use of plant polysaccharides in complex treatment of malignant tumors. Experimental and Clinical Pharmacology. 2012; 75(9):427. (In Russ).
  26. Yamamoto Y, Suzuki T, Hirano M, et al. Effect of fucoidan and fucoidan containing tea on gastric ulcer and nonulcer dyspepsia. The Japanese Journal of Pharmacology. 2000;28:6370.
  27. Ito M, Ban A, Ishihara M. Antiulcer effects of chitin and chitosan, healty foods in rats. The Japanese Journal of Pharmacology. 2000;82: 21825. doi: 10.1254/jjp.82.218
  28. Katayama H, Nishimura T, Ochi S, et al. Sustained release liquid preparation using sodium alginate for eradication of Нelicobacter pylori. Biological and Pharmaceutical Bulletin. 1999; 22:5560. doi: 10.1254/jjp.82.218
  29. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Nutrition Journal. 1995;125(6):14012. doi: 10.1093/jn/ 125.6.1401
  30. Block ML, Zecca L, Hong JS. Microgliamediated neurotoxicity: uncovering the molecular mechanisms. Nature Reviews Neuroscience. 2007;8(1):5769. doi: 10.1038/nrn2038
  31. Besednova NN, Somova LM, Gulyaev SA, et al. Neuroprotective effects of sulfated polysaccharides from seaweed. Vestnik rossiyskoy akademii meditsinskikh nauk. 2013;68(5):529. (In Russ).
  32. Cui YQ, Zhang LJ, Zhang T, et al. Inhibitory effect of fucoidan on nitrit oxide production in lipopolysaccharideactivated primary microglia. Clinical And Experimental Pharmacology And Physiology. 2010;37:4228. doi:10.1111/ j.14401681.2009.05314.x
  33. Lee HR, Do H, Lee SR, et al. Effects of fucoidan on neuronal сell proliferation assotiation with NO production through the iNOS pathway. Journal of Food Science and Nutrition. 2007;12:748. doi: 10.3746/jfn.2007.12.2.074
  34. Do H, Pyo S, Sohn EH. Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK, JAK/STAT, AP1 and IFR1, and dependents on upregulation of scavenger receptor B1 expression in TNFα and IFNγstimulated C6 glioma cells. Journal of Nutritional Biochemistry. 2010;21(8):6719. doi: 10.1016/j.jnutbio.2009.03.013
  35. Luo D, Zhang Q, Wang H., et al. Fucoidan protects against dopaminergic neuron death in vivo and in vitro. European Journal of Pharmacology. 2009;617(13):3340. doi: 10.1016/j. ejphar.2009.06.015
  36. Zlobin AA, Martinson YA, Ovechkina IA, et al. Sostav i svoystva pektinovykh polisakharidov zveroboya prodyryavlennogo Hypericum perforatum L. Khimiya rastitel'nogo syr'ya. 2011;1:338. (In Russ).
  37. Kryzhanovsky SP, Bogdanovich LN, Besednova NN, et al. Hypolipidemic AND antiinflammatory effects of polysaccharides marine brown kelps in patients with dyslipidemia. Fundamental research. 2014;10:93100. (In Russ).
  38. Huang R, Du Y, Yang J, et al. Influence of functional groups on the in vitro anticoagulant activity of chitosan sulfate. Carbohydrate Research. 2003;338:4839. doi: 10.1055/s00311299848
  39. Matou S, Helley D, Chabut D, et al. Effect of fucoidan on fibroblast growth factor2induced angiogenesis in vitro. Thrombosis Research. 2002; 106:21321. doi: 10.1016/S00493848 (02)001366
  40. Millet J, Jouault CS, Mauray S, et al. Antithrombotic and anticoagulant activities of a low molecular weight fucoidan. Journal of Thrombosis and Haemostasis. 1999;81:3915.
  41. Yakusheva EN, Engalycheva EE, Sychev IA, Shchulkin AV. Pharmacological evaluation polysaccharide complex flowers tansy. Fundamental research. 2015;2(4):4554. (In Russ).

Copyright (c) 2018 Chernykh I.V., Kirichenko E.E., Shchulkin A.V., Popova N.M., Kotlyarova A.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies