Email this article POSSIBLE WAYS OF STIMULATION OF NITRIC OXIDE PRODUCTION AS THE MAIN INDUCTOR OF ENDOTHELIAL DYSFUNCTION USING CARDIOTROPIC DRUGS IN PATIENTS WITH PERIPHERAL OCCLUSIVE ARTERIAL DISEASE
- Issue: Vol 19, No 2 (2011)
- Pages: 8-8
- Section: Articles
- URL: https://journals.rcsi.science/pavlovj/article/view/5200
- DOI: https://doi.org/10.17816/PAVLOVJ201128-8
- ID: 5200
Cite item
Full Text
Abstract
The open randomized trial meeting the ICH GCP criteria included 4 groups of patients with peripheral occlusive arterial disease, stage IIA-III according to the Fontaine classification in modification by Pokrovsky. The first group was given 5mg of nebivolol qd po, the second was given perindopril 5, 10 mg qd po, the third - L-arginine 500mg bid po during 30 days. Group 4 was a control group.
After a 30-days period of conservative therapy we observed a 70% increase of NO level in the first group, 95% increase in the 2nd group and 539% increase in the 3rd. A reliable increase of nitric oxide metabolites correlated with improvement in clinical findings as well as functional tests. Treadmill test improved by 22%, 20%, and 32% respectively. Rheographic test improved in all study groups and its values exceeded the normal ones by 15-25% (P<0.05).
After a 30-days period of conservative therapy we observed a 70% increase of NO level in the first group, 95% increase in the 2nd group and 539% increase in the 3rd. A reliable increase of nitric oxide metabolites correlated with improvement in clinical findings as well as functional tests. Treadmill test improved by 22%, 20%, and 32% respectively. Rheographic test improved in all study groups and its values exceeded the normal ones by 15-25% (P<0.05).
Keywords
References
- Калинин Р.Е. Комплексная оценка функционального состояния эндотелия у больных облитерирующим атеросклерозом артерий нижних конечностей при различных методах оперативного лечения: Дис… д-ра мед. наук/ Р.Е.Калинин.- Рязань, 2008.-250с.
- Киричук В.Ф. Дисфункция эндотелия / В.Ф. Киричук, П.В. Глыбочко , А.И. Пономарева.- Саратов: Изд-во Саратовского мед.ун-та, 2008.-129с.
- Клиническая ангиология: Руководство/ под ред. А.В. Покровского: в 2 т.- М.: Медицина, 2006. - Т.1.-808 с.-Т.2.- 888 с.
- Национальные рекомендации по ведению пациентов с сосудистой артериальной патологией. Часть 1. Периферические артерии. Москва, 2010.-78с.
- Небиеридзе Д.В. Метаболические и сосудистые эффекты β-адреноблокаторов / Д.Р. Небиеридзе, Р.Г. Оганов // Справочник поликлинического врача.- 2007.- № 5.- C. 27-31.
- Пшенников А.С. Одноэтапный метод определения уровня метаболитов оксида азота в сыворотке крови / А.С. Пшенников // Материалы науч.-практ. конф. «Актуальные вопросы современной медицины: взгляд молодого специалиста».- Рязань: РИО РязГМУ, 2010.- С. 183-185.
- Luscher T.F., Noll.G. The pathogenesis of cardiovascular disease: role of the endothelium as a target and mediator / T.F. Luscher , G.Noll // Atherosclerosis.- 1995 Dec.-118 Suppl: P.81-90.
- Moncada S. The discovery of nitric oxide as the endogenous nitrovasodilator/ S. Moncada, R.M. Palmer, E.A. Higgs // Hypertension.- 1988 Oct.-12(4).- P. 365-72.
- Preservation of endotheliumdepent vascular relaxation in cholesterolfed rabbit by treatment with the calcium blocker PN 200110 / J.B. Habib et al. // Circ Res.- 1986.- 58.-P.30-59.
- Process of Care Partly Explains the Variation in Mortality Between Hospitals After Peripheral Vascular Surgery / K.E. Hoeks et al.// Eur О Vasc Endovasc Surg.-2010.-40.-P.147-154.
- Weber M.A. The role of the new beta-blockers in treating cardiovascular heart disease /M.A. Weber //Am J Hypertens.- 2005.- Vol. 18, No. 12 (Pt 2).- P. 169-176.
- Willem-Jan Flu. Timing of pre-operative beta-blocker treatment in vascular surgery patients /Flu Willem-Jan et al.//J Am Coll Cardiol.2010.- 56(23). - 1922-9.
Supplementary files
