SEMAX INFLUENCE ON RAT CARDIOMYOCITE APOPTOTIC CELL DEATH IN IRREVERSIBLE ISCHEMIA AND ISCHEMIA-REPERFUSION
- Issue: Vol 19, No 2 (2011)
- Pages: 2-2
- Section: Articles
- URL: https://journals.rcsi.science/pavlovj/article/view/5194
- DOI: https://doi.org/10.17816/PAVLOVJ201122-2
- ID: 5194
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Abstract
5 groups of male rats were investigated: control group; irreversible ischemia with drug and without; the animals with reperfusion after 2.5 hours of ischemia with drug and without it. Samples for light microscopy (haematoxylin-eosin and TUNEL-analysis) of the risk area (anterior wall of left ventricle) and conditionally intact myocardium (lateral wall and interventricular septum) were taken 72 hours after intervention. Semax were injected intraperitoneally at a dose of 150 mg / kg after 15 minutes and after 2 hours 15 minutes after ligation of coronary artery. The necrosis was formed in the anterior wall area both under irreversible ischemia and ischemia-reperfusion. Substantial morphological changes also developed in areas of relatively intact myocardium. These signs are accompanied by a significant increase of apoptotic index. Semax had no effects on the morphology of myocardium, but significantly reduced apoptosis of cardiomyocytes.
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References
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