Expression of GABA transporter (GAT-1) and GLIAL FIDRILLAR ACIDIC PROTEIN (GFAP) in maturated human neocortex

GABA transporter (GAT-1) distribution in the human neocortex sulcuses (fetus from 14 weeks prenatal till four years old human) was researched by immunohistochemistry method. Intensive GAT-1 positive staining in the fissure lip from fetus neocortex was detected. GAT-1 positive staining decreased with different intensivity in the sulcuses and in the straight surfaces of neocortex, depended of fetus age. After birth the lips and the straight surfaces of neocortex was stained uniform, but was kept the decay of labeling in the fissures. From 26 till 33 prenatal weeks GAT-1 positive terminals innervated subventricular/ventricular zone, where they blocked cell progenitor proliferation, whereby triggered the astrocytic differentiation.

GABA, the neocortex, immunohistochemistry, brain, the neocortex, the differentiation of astrocytes