Email this article Method for the quantative determination of β-hydroxysimvastatin in blood plasma
- Issue: Vol 19, No 4 (2011)
- Pages: 141-146
- Section: Articles
- URL: https://journals.rcsi.science/pavlovj/article/view/4949
- DOI: https://doi.org/10.17816/PAVLOVJ20114141-146
- ID: 4949
Cite item
Full Text
Abstract
Article is devoted working out of an original HPLC method of quantitative determination of β-hydroxysimvastatin in the blood plasma. In work the HPLC system "Stayer" with the spektro-photometric detector was used. Analysis was achieved on the reversed phase column «Beckman Coulter». Separation of β-hydroxysimvastatin from the blood plasma carried out a method liquid Extraction
Keywords
Full Text
##article.viewOnOriginalSite##References
- Аронов Д.М. Лечение и профилактика атеросклероза / Д.М. Аронов. – М.: Триада-Х, 2000. – 411 с.
- Аронов Д.М. Симвастатин / Д.М. Аронов. – М.: Триада-Х, 2002. – 80 с.
- Орлов В.И. Жидкостная хроматография. Теоретические основы / В.И. Орлов, А.А. Аратсков. – Дзержинск, 1997. – 41 с.
- Соколов А.В. Клиническая фармакокинетика / А.В. Соколов. – М.: Типография «Верже», 2004. – 55 с.
- Стыскин Е.Л. Практическая высокоэффективная жидкостная хроматография / Е.Л. Стыскин, Л.Б. Ициксон, Е.В. Брауде. – М., 1986. – 205 с.
- Bioeuivalence assesment of two simvastatin tablets in healthy Taiwanese volunteers / Chih-Neng [et al.] // Journal of food and drug analysis. – 2007. – Vol. 15. – P. 15-19.
- Determination of simvastatin in human plasma by column-switching HPLC with UV detection / Kim Bae-Chan [et al.] // Journal of liquid chromatography & related technologies. – 2004. – Vol. 27. – P. 3089-3102.
- Determination of Simvastatin in human plasma by liquid chromatography–mass spectrometry / Haitao Yang [et al.] // Journal of Chromatography B. – 2003. – Vol. 785. – P. 369-375.
- HPLC determination of ezetimibe and simvastatin in pharmaceutical formulations / Muhammad Ashfaq [et al.] // Journal of the Chilean Chemical Society. – 2007. – Vol. 52. – P. 1220-1223.
- HPLC determination of simvastatin and nicotinic acid in tablets / M. Gandhimathi [et al.] // Indian drugs. – 2003. – Vol. 40. – P. 707-711.
- Nagaraju P. A validated reverse phase HPLC method for the simulations estimation of simvastatin and ezetimibe in pharmaceutical dosage forms / P. Nagaraju, Z. Vishnu vardhan // Journal of Global Pharma Technology – 2010. – Vol. 24. – P. 113-117.
- Rainville P. Transfer of the USP assay for simvastatin to UPLC / P. Rainville, R. Plumb // Ultraperfomance LC. – 2007. – Vol. 80. – P. 9-11.
- Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid / B. Nigovic [et al] // Croatia Chemmical Acta. – 2008. – Vol. 81. – P. 453-459.
Supplementary files
