Email this article Influence of the thyroxine on the functional activity of the р-glycoprotein in the experiment
- Issue: Vol 19, No 4 (2011)
- Pages: 49-53
- Section: Articles
- URL: https://journals.rcsi.science/pavlovj/article/view/4930
- DOI: https://doi.org/10.17816/PAVLOVJ2011449-53
- ID: 4930
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Abstract
In the research on the rabbits influence of a L-thyroxine on the activity of the protein- transporter Р-glycoprotein (Pgp) was studied. Activity of the Pgp was investigated on the pharmacokinetics of its marker substrate fexofenadine. It was established that introduction of a L-thyroxine within 14 days lead to dose-dependent rising of Рgp activity.
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