Significance of immunohistochemistry method for diagnosing of stomach tumors

Abstract

The article is dedicated to the diagnosis of malignant tumors of the stomach, analyzing divergences of diagnoses after routine morphological researches and immunomorphological methods with monoclonal antibodies using, assessment of proliferative activity of different groups of tumors of this localization. Our investigation demonstrated that in the group of gastric tumors mistaken primary diagnoses were identified in 33 of 62 cases (53.2%). Proliferative score estimation is too important to determine the potential for malignancy of gastrointestinal stromal tumors and the degree of differentiation of neuroendocrine cancers.

References

  1. Аруин Л.И. Морфологическая диагностика болезней желудка и кишечника / Л.И. Аруин, Л.Л. Капуллер, В.А. Исаков. - М.: Изд-во «Триада-Х», 1998. -496 с.
  2. Виноградов И.И. Значение маркеров пролиферации и апоптоза для пограничных опухолей яичника / И.И. Виноградов // Рос. медико-биол. вестн. им. акад. И.П. Павлова. - 2013. - № 3. - С. 130-136.
  3. Мнихович М.В. Межклеточные и клеточно-матриксные взаимодействия в опухолях: современное состояние проблемы / М.В. Мнихович // Рос. медико-биол. вестн. им. акад. И.П. Павлова. - 2013. - № 3. - С. 161-171.
  4. Петров С.В. Руководство по иммуно-гистохимической диагностике опухолей человека / С.В. Петров, Н.Т. Райхлин. - 3-е изд., доп. и перераб. - Казань: Титул, 2004. - 456 с.
  5. Fletcher Christopher Diagnostic histopathology of tumors / Christopher Fletcher. - 4-th ed. - China: Elsevier Saunders, 2013. - 2156 p.
  6. Wong Hannah H. Immunohistochemical features of the gastrointestinal tract tumors / Hannah H. Wong, Peiguo Chu // J. Gastrointest Oncol. - 2012. - Vol. 3, №3. - Р. 262-284.
  7. Miettinen M. Histopathology of gastrointestinal stromal tumor / M. Miettinen, J. Lasota // Journal of surgical oncology. - 2011. - Vol. 104, № 8. - Р. 865-873.
  8. Neuroendocrine carcinoma of the stomach: clinicopathological and immunohistochemical evaluation / T. Namikawa [et al.] // Med. Mol. Morphol. - 2013. -Vol. 46, № 1. - Р. 34-40.
  9. Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis / M. Ishida [et al.] // Am J Surg Pathol. -2013. - Vol. 37, № 7. - Р. 949-959.
  10. World Health Organization of Pathology and Genetics of Tumours of the Digestive System / eds. : Stanley R. Hamilton, Lauri A. Aaltonen. - Lyon, France: IARC Press, 2000. - 314 p.

Copyright (c) 2014 Shponka I.S., Poslavskaya A.V., Yakovenko V.R.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies