CHARACTERISTICS AND TRENDS OF PRIMARY DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS IN RYAZAN REGION
- Issue: Vol 20, No 4 (2012)
- Pages: 14-19
- Section: Articles
- URL: https://journals.rcsi.science/pavlovj/article/view/4673
- DOI: https://doi.org/10.17816/PAVLOVJ2012414-19
- ID: 4673
Cite item
Full Text
Abstract
The article is devoted to drug-resistant tuberculosis in the Ryazan region. There is a tendency to the increase of the amount of tubercular patients among women of middle ages. It is stated that in the period from 1999 to 2007 mycobacteria’s structure of drug-resistance has not changed considerably. The exception was a dramatic increase of cases with simultaneous drug-resistance to the four first-line antibiotics. The direct interdependence between the character of drug-resistance and the speed and intensity of tuberculosis microorganisms growth has not been found yet.
Full Text
##article.viewOnOriginalSite##References
- Данилова Е.В. Особенности клинического течения и эффективности лечения больных туберкулезом органов дыхания с первичной лекарственной устойчивостью возбудителя: дис.. к.м.н. - Иваново, 2005.
- Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis // Antimicrobial Agents and Chemotherapy. - 2009. - Vol. 43, № 8. - P. 1866-1869.
- World Health Organization. Global tu berculosis control: surveillance, planning, financing WH0/HTM/TB/2011.16. - Geneva, Switzerland: WHO, 2011.
- Impact of drug resistance on fitness of Mycobacterium tuberculosis strains of the W-Beijing genotype // FEMS Immunol. Med. Microbiol. - 2004. - № 42. - P. 281-290.