The relationship between ADD1 (Gly460Trp) rs4961 polymorphism and the main physiological parameters of the cardiovascular system in pregnant women

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

INTRODUCTION: Physiological development of pregnancy is possible only with the proper functioning of the cardiovascular system (CVS) of mother in general and of the placental vascular system in particular. Research continues into the factors and genetic polymorphisms that influence the development of cardiovascular diseases in women during pregnancy.

AIM: To evaluate the relationship between the ADD1 (Gly460Trp) rs4961 polymorphism and CVS parameters in women during pregnancy.

METHODS: The study included 170 pregnant women aged 20 to 38 years in the third trimester of pregnancy. Of these 76 women with normotensive pregnancy (control group) and 94 women with gestational arterial hypertension. Echocardiography, cardiotocography, assessment of uteroplacental and fetoplacental blood flow with determination of the resistance indices (RI) of the uterine arteries and umbilical artery were performed. Genotyping of the ADD1 (Gly460Trp) rs4961 polymorphism was performed using the TagMan probe detection method based on the relative fluorescence units of each probe on a CFX96 amplifier with a detection system in Real-time mode. Bio-Rad IQ5-Standart Edition software was used for allele discrimination.

RERSULTS: In the control group, Gly/Trp and Trp/Trp genotype carriers had a higher cross-sectional area of the left ventricle (LV) in diastole and increased end-diastolic and stroke volumes of the LV compared with similar parameters in women with Gly/Gly genotype (р <0.05). Women with Trp/Trp genotype were found to have elevated levels of systolic, diastolic and pulse blood pressure compared with Gly/Gly and Gly/Trp genotype carriers (р <0.05). In women with normotensive pregnancy with Gly/Trp genotype, higher levels of RI of the umbilical artery (by 9.3%), right uterine artery (by 10.6%), and left uterine artery (by 10.4%) were observed compared with Gly/Gly genotype carriers (р <0.05).

CONCLUSION: The ADD1 (Gly460Trp) rs4961 polymorphism is most significant in the Gly/Trp and Trp/Trp genotypes, which are associated with a larger LV diastolic volume in women with normotensive pregnancy. The pregnant women with Trp/Trp genetic variants were found to have the highest systolic, diastolic, and pulsed pressure levels. In women with normotensive pregnancy, an informative parameter of the functional condition of the umbilical and left uterine arteries is Gly/Trp of ADD1 (Gly460Trp) rs4961 polymorphic variant.

About the authors

Inna A. Topol

Belgorod State National Research University

Author for correspondence.
Email: topol@bsu.edu.ru
ORCID iD: 0000-0001-7729-1465
SPIN-code: 9027-3896

Cand. Sci. (Biology)

Russian Federation, Belgorod

Anna V. Elykova

Belgorod State National Research University

Email: elykova_a@bsu.edu.ru
ORCID iD: 0000-0002-9511-6895
SPIN-code: 9235-9713

Cand. Sci. (Biology)

Russian Federation, Belgorod

Irina S. Polyakova

Belgorod State National Research University

Email: polyakovairina@bsu.edu.ru
ORCID iD: 0000-0002-0228-3513
SPIN-code: 1216-1892

Cand. Sci. (Biology)

Russian Federation, Belgorod

Evgeny A. Reshetnikov

Belgorod State National Research University

Email: reshetnikov@bsu.edu.ru
ORCID iD: 0000-0002-5429-6666
SPIN-code: 1667-0980

Dr. Sci. (Biology), Assistant Professor

Russian Federation, Belgorod

References

  1. Sanghavi M, Rutherford JD. Cardiovascular physiology of pregnancy. Circulation. 2014;130(12):1003–1008. doi: 10.1161/circulationaha.114.009029
  2. Visentin S, Palermo C, Camerin M, et al. Echocardiographic Techniques of Deformation Imaging in the Evaluation of Maternal Cardiovascular System in Patients with Complicated Pregnancies. Biomed Res Int. 2017;2017:4139635. doi: 10.1155/2017/4139635
  3. Keser N. Echocardiography in pregnant women. Anadolu Kardiyol Derg. 2006;6(2):169–173.
  4. Baev TО, Panova IA, Kuzmenko GN, et al. The state of microcirculation in pregnant women with hypertensive disorders in the third trimester of pregnancy. Research Results in Biomedicine. 2023;9(1):113–128. doi: 10.18413/2658-6533-2023-9-1-0-8 EDN: XWOCIB
  5. Antropova ON, Obraztsova LA. Salt-sensitive hypertension: modern pathogenetic mechanisms and prospects. Arterial Hypertension. 2023;29(1):6–13. doi: 10.18705/1607-419X-2023-29-1-6-13 EDN: DGFSIF
  6. Moiseeva IE. Hypertension in pregnancy in general practice. Russian Family Doctor. 2019;23(2):15–20. doi: 10.17816/RFD2019215-20 EDN: ALCKLV
  7. Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, et al.; 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J. 2018;39(34):3165–3241. doi: 10.1093/eurheartj/ehy340 EDN: ZZCJRP
  8. Arakelyants AA, Morozova TE, Barabanova EA, Samokhina EO. Structural and functional heart features in pregnancy with concomitant cardiovascular diseases. Lechaschi Vrach. 2021;(7):18–23. doi: 10.51793/OS.2021.24.7.004 EDN: LKEEYE
  9. Zhang JR, Hu WN, Li CY. A Review of the Epidemiological Evidence for Adducin Family Gene Polymorphisms and Hypertension. Cardiol Res Pract. 2019;2019:7135604. doi: 10.1155/2019/7135604 EDN: ONIXXP
  10. Jin H, Huang Y, Yang G. Association between α-adducin rs4961 polymorphism and hypertension: a meta-analysis based on 40 432 subjects. J Cell Biochem. 2019;120(3):4613–4619. doi: 10.1002/jcb.27749
  11. Churnosov MI, Reshetnikov EA, Akulova LYu, et al. Gene polymorphism of vasoactive hormones and echocardiographic indicators in women. Chelovek i ego Zdorov'ye. 2011;(4):161–165. (In Russ.) EDN: ORNLTF
  12. Sizova OV, Radkov OV, Paramonova EK, Korichkina LN. Association of the aldosterone synthase, alpha-adducin, g-protein β3 subunit and β1-adrenergic receptor with chronic hypertension in pregnant women. Journal of New Medical Technologies. 2018;25(4):30–36. EDN: YRWKMP
  13. Fava C, Montagnana M, Almgren P, et al. Association between adducin-1 G460W variant and blood pressure in Swedes Is dependent on interaction with body mass index and gender. Am J Hypertens. 2007;20(9):981–989. doi: 10.1016/j.amjhyper.2007.04.007
  14. Curtis SL, Belham M, Bennett S, et al. Transthoracic Echocardiographic Assessment of the Heart in Pregnancy — a position statement on behalf of the British Society of Echocardiography and the United Kingdom Maternal Cardiology Society. Echo Res Pract. 2023;10(1):7. doi: 10.1186/s44156-023-00019-8 EDN: TDGJBK
  15. Gonzalez–Fernandez E, Fan L, Wang Sh, et al. The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension — vascular, renal, and cognitive diseases. Physiol Genomics. 2022;54(2):58–70. doi: 10.1152/physiolgenomics.00119.2021 EDN: IPIBFS
  16. Mandò C, Antonazzo P, Tabano S, et al. Angiotensin-Converting Enzyme and Adducin-1 Polymorphisms in Women With Preeclampsia and Gestational Hypertension. Reprod Sci. 2009;16(9):819–826. doi: 10.1177/1933719109336612 EDN: NTIQHL
  17. Beeks E, van der Klauw MM, Kroon AA, et al. α-Adducin Gly460Trp Polymorphism and Renal Hemodynamics in Essential Hypertension. Hypertension. 2004;44(4):419–423. doi: 10.1161/01.hyp.0000141410.72537.fd
  18. Iatrino R, Manunta P, Zagato L. Salt Sensitivity: Challenging and Controversial Phenotype of Primary Hypertension. Curr Hypertens Rep. 2016;18(9):70. doi: 10.1007/s11906-016-0677-y EDN: VKFNWY
  19. Desai DK, Moodley J, Naidoo DP. Echocardiographic Assessment of Cardiovascular Hemodynamics in Normal Pregnancy. Obstet Gynecol. 2004;104(1):20–29. doi: 10.1097/01.aog.0000128170.15161.1d
  20. Reshetnikov EA, Orlova VS, Pahomov SP, et al. The association of polymorphisms of vascular reaction genes with blood pressure levels in pregnant women of Belgorod region. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2016;7(6):3262–3266. EDN: XMNVVO

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2025 Eco-Vector

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).