Experimentally Justified Choice of Optimal Antiseptic Solution for Hygienic Care of Oral Cavity and Dentures

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Abstract

INTRODUCTION: The range of antiseptic agents used in clinical practice, is rather wide. However, only single studies are devoted to comparative characteristics of their effectiveness in the conditions of the oral cavity.

AIM: To choose the optimal antiseptic dental cleaner by experimental study.

MATERIALS AND METHODS: An aqueous solution of Furacilin® (0.02%), chlorhexidine bigluconate (0.05%), Miramistin® (0.01%), cetylpyridinium chloride (0.05%), hydrogen peroxide (3%), Iodinol®, Rotokan®, distilled water were used as washing liquids for elimination of dental plaque. The model of the dentition was created from quartz plates with an imitation of fresh plaque. Biomaterial imitating dental plaque included two solutions: 1) a strong fresh infusion of black tea leaves, cooled to +25°C; 2) oatmeal jelly with temperature from +60°C to +65°C. The authors’ method of screening dental cleaners was used, based on comparing the transparency of the laboratory model of the dentition before and after exposure to the test solution by determination with an amperemeter of strength of the electric current in the photosensor device from the oxyhemograph sensor after white light emitted by a mini-emitter passed through biological material and plates and fell on it.

RESULTS: The cleaning capacity of distilled water is the lowest (p < 0.05–0.001). Rotokan®, Furacilin® and Iodinol® have a low cleaning capacity, and Iodinol® can cause a burn of the gingival cuff in case of high reaction to it, and allergic reactions. Hydrogen peroxide has an average degree of efficiency, but it dries the oral mucosa. Chlorhexidine bigluconate has the highest cleaning effect, Miramistin® and cetylpyridinium chloride are slightly inferior to it (p > 0.05). By the cleaning capacity, chlorhexidine bigluconate solution is significantly superior to hydrogen peroxide (p < 0.05), Iodinol® (p < 0.02), Furacilin® (p < 0.02), Rotokan® (p < 0.01).

CONCLUSION: The described method received the patent for invention of the Russian Federation No. 2019121293. Experimental studies have shown the best cleaning effect of 0.05% solution of chlorhexidine bigluconate.

About the authors

Roman A. Rozov

City Dental Clinic No 33; Yaroslavl - the - Wise Novgorod State University

Email: dds.rozov@gmail.com
ORCID iD: 0000-0001-5804-9497
SPIN-code: 1173-7870
Scopus Author ID: 57205048723
ResearcherId: E-3677-2019

MD, Cand. Sci. (Med.), Associate Professor

Russian Federation, Saint Petersburg; Novgorod

Vladimir N. Trezubov

Yaroslavl - the - Wise Novgorod State University; Academician I. P. Pavlov First Saint-Petersburg State Medical University

Email: trezubovvn@mail.ru
ORCID iD: 0000-0003-0532-5632
SPIN-code: 2588-7283

MD, Dr. Sci. (Med.); Professor

Russian Federation, Novgorod; Saint Petersburg

Vladimir D. Vagner

Central Research Institute of Stomatology and Maxillofacial Surgery; Ryazan State Medical University

Email: vagnerstar@yandex.ru
ORCID iD: 0000-0002-9136-9289
SPIN-code: 2587-3559
Scopus Author ID: 7003750386

MD, Dr. Sci. (Med.); Professor

Russian Federation, Moscow; Ryazan

Aleksandr L. Urakov

Izhevsk State Medical Academy

Author for correspondence.
Email: urakoval@live.ru
ORCID iD: 0000-0002-9829-9463
SPIN-code: 1613-9660

MD, Dr. Sci. (Med.); Professor

Russian Federation, Izhevsk

Aleksey P. Reshetnikov

Izhevsk State Medical Academy

Email: areshetnikov@list.ru
ORCID iD: 0000-0003-4826-8404
SPIN-code: 4115-4167

MD, Cand. Sci. (Med.)

Russian Federation, Izhevsk

References

  1. Hernández–Vásquez A, Barrenechea–Pulache A, Comandé D, et al. Mouthrinses and SARS-CoV-2 viral load in saliva: a living systematic review. Evidence–Based Dentistry. 2022;23(2):47. doi: 10.1038/s41432-021-0212-0
  2. Garcia–Sanchez A, Peña–Cardelles J–F, Salgado–Peralvo A–O, et al. Virucidal Activity of Different Mouthwashes against the Salivary Load of SARS-CoV-2: A Narrative Review. Healthcare. 2022;10(3):469. doi: 10.3390/healthcare10030469
  3. Coelho ASEC, Paula ABP, Carrilho TMP., et al. Chlorhexidine mouthwash as an anticaries agent: A systematic review. Quintessence International. 2017;48(7):585–91. doi: 10.3290/j.qi.a38353
  4. Charadram N, Maniewicz S, Maggi S, et al. Development of a European consensus from dentists, dental hygienists and physicians on a standard for oral health care in care-dependent older people: An e-Delphi study. Gerodontology. 2021;38(1):41–56. doi: 10.1111/ger.12501
  5. Hua F, Xie H, Worthington H, et al. Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. The Cochrane Database of Systematic Reviews. 2016;10(10):CD008367. doi: 10.1002/14651858.CD008367.pub3
  6. James P, Worthington HV, Parnell C, et al. Chlorhexidine mouthrinse as an adjunctive treatment for gingival health. The Cochrane Database of Systematic Reviews. 2017;3(3):CD008676. doi: 10.1002/14651858.CD008676.pub2
  7. Rozov RA, Trezubov VN, Gerasimov AB, et al. Clinical analysis of the short-term and long-term results of the implant-supported Trefoil dental rehabilitation in Russia. Stomatologiya. 2020;99(5):50–7. (In Russ). doi: 10.17116/stomat20209905150
  8. Arutyunov AS, Shanidze ZL, Tsareva EV, et al. Prosthodontic treatment of edentulous patients with postoperative mandibular defects of oncological origin. Stomatologiya. 2018;97(1):54–8. (In Russ). doi: 10.17116/stomat201897154-58
  9. AlHamdan EM, Al-Saleh S, Nisar SS, et al. Efficacy of porphyrin derivative, Chlorhexidine and PDT in the surface disinfection and roughness of Cobalt chromium alloy removable partial dentures. Photodiagnosis and Photodynamic Therapy. 2021;36:102515. doi: 10.1016/j.pdpdt.2021.102515
  10. Soheilifar S, Khodadadi H, Naghdi N, et al. Does a diluted chlorhexidine-based orthodontic mouthwash cause less discoloration compared to chlorhexidine mouthwash in fixed orthodontic patients? A randomized controlled trial. International Orthodontics. 2021;19(3):406–14. doi: 10.1016/j.ortho.2021.05.001
  11. Van Swaaij BWM, van der Weijden GAF, Bakker EWP, et al. Does chlorhexidine mouthwash, with an anti-discoloration system, reduce tooth surface discoloration without losing its efficacy? A systematic review and meta-analysis. International Journal of Dental Hygiene. 2020;18(1):27–43. doi: 10.1111/idh.12402
  12. Karakis D, Akay C, Oncul B, et al. Effectiveness of disinfectants on the adherence of Candida albicans to denture base resins with different surface textures. Journal of Oral Science. 2016;58(3):431–7. doi: 10.2334/josnusd.15-0642
  13. Da Costa LFNP, da Silva Furtado Amaral C, da Silva Barbirato D, et al. Chlorhexidine mouthwash as an adjunct to mechanical therapy in chronic periodontitis: A meta-analysis. Journal of the American Dental Association. 2017;148(5):308–18. doi: 10.1016/j.adaj.2017.01.021
  14. Canullo L, Laino L, Longo F, et al. Does Chlorhexidine Prevent Complications in Extractive, Periodontal, and Implant Surgery? A Systematic Review and Meta-analysis with Trial Sequential Analysis. The International Journal of Oral & Maxillofacial Implants. 2020;35(6):1149–58. doi: 10.11607/jomi.8216
  15. Solderer A, Kaufmann M, Hofer D, et al. Efficacy of chlorhexidine rinses after periodontal or implant surgery: a systematic review. Clinical Oral Investigations. 2019;23(1):21–32. doi: 10.1007/s00784-018-2761-y
  16. Corbella S, Del Fabbro M, Taschieri S, et al. Clinical evaluation of an implant maintenance protocol for the prevention of peri-implant diseases in patients treated with immediately loaded full-arch rehabilitations. International Journal of Dental Hygiene. 2011;9(3):216–22. doi: 10.1111/j.1601-5037.2010.00489.x
  17. Gurevich K, Urakov A, Fisher E, et al. Alkaline Hydrogen Peroxide Solution is an Expectorant, Pyolytic, Mucolytic, Hemolytic, and Bleaching Drug for Treating Purulent Diseases, Hematomas and Bruising. Journal of Pharmaceutical Research International. 2022;34(30B):13–20. doi: 10.9734/jpri/2022/v34i30B36073
  18. Elkerbout TA, Slot DE, Bakker EWP, et al. Chlorhexidine mouthwash and sodium lauryl sulphate dentifrice: do they mix effectively or interfere? International Journal of Dental Hygiene. 2016;14(1):42–52. doi: 10.1111/idh.12125
  19. Shi Y, Yang N, Zhang L, et al. Chlorhexidine disinfectant can reduce the risk of central venous catheter infection compared with povidone: a meta-analysis. American Journal of Infection Control. 2019;47(10):1255–62. doi: 10.1016/j.ajic.2019.02.024
  20. Urakov AL, Reshetnikov AP, Rozov RA, et al. Method for screening dental cleansers on model of transparent teeth coated with dental deposit. Patent RUS № 2725131. 30.06.2020. Byul. № 19. Available at: https://fips.ru/registers-doc-view/fips_servlet?DB=RUPAT&DocNumber=2725131&TypeFile=html. Accessed: 2022 June 09. (In Russ).

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2. Fig. 1. Experimental set-up: light source (a); one of four glass plates imitating front teeth (b); photocell (c) connected with ammeter (d); oatmeal decoction (e); a film (f) of black tea imitating tooth plaque (g).

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Copyright (c) 2022 Rozov R.A., Trezubov V.N., Vagner V.D., Urakov A.L., Reshetnikov A.P.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


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